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公开(公告)号:US20090306608A1
公开(公告)日:2009-12-10
申请号:US12437163
申请日:2009-05-07
CPC分类号: A61F9/0017 , A61F9/00772 , A61F2250/0068 , A61K9/0043 , A61K9/0051
摘要: The invention provides devices useful for the delivery of active agents to the eye in a controlled manner. In the devices of the invention, the active agent is present within the device in a continuous or discontinuous concentration gradient.
摘要翻译: 本发明提供了用于以受控方式将活性剂递送至眼睛的装置。 在本发明的装置中,活性剂以连续或不连续的浓度梯度存在于装置内。
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公开(公告)号:US20060293674A1
公开(公告)日:2006-12-28
申请号:US11159536
申请日:2005-06-23
申请人: Zhigang Li , Kevin Cooper , Raymond Shissias , Qiang Zhang
发明人: Zhigang Li , Kevin Cooper , Raymond Shissias , Qiang Zhang
IPC分类号: A61B17/58
CPC分类号: A61B17/0401 , A61B2017/00526 , A61B2017/0412 , A61B2017/0414 , A61B2017/0427 , A61B2017/044 , A61B2017/0458
摘要: A device for use in tissue repair, a method of using the device in a surgical procedure and a method of making the device. The device is an assembly of a cannulated anchor with a cord passed through it, and a stopper to prevent the cord from passing back through the anchor.
摘要翻译: 用于组织修复的装置,在外科手术中使用该装置的方法以及制造该装置的方法。 该装置是具有穿过其的绳索的插管锚的组件,以及用于防止绳索穿过锚固件的塞子。
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公开(公告)号:US20060290029A1
公开(公告)日:2006-12-28
申请号:US11159539
申请日:2005-06-23
申请人: Zhigang Li , Kevin Cooper , Raymond Shissias , Qiang Zhang
发明人: Zhigang Li , Kevin Cooper , Raymond Shissias , Qiang Zhang
IPC分类号: B29C45/14
CPC分类号: B29C43/18 , A61B17/0401 , A61B2017/044 , A61B2017/0458 , B29C2043/181 , B29K2105/258 , B29K2995/0056 , B29L2031/753
摘要: A device for use in tissue repair, a method of using the device in a surgical procedure and a method of making the device. The device is an assembly of a cannulated anchor with a cord passed through it, and a stopper to prevent the cord from passing back through the anchor.
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公开(公告)号:US09474645B2
公开(公告)日:2016-10-25
申请号:US11759269
申请日:2007-06-07
申请人: Han Cui , Zhigang Li , Edgar V. Menezes , Aruna Nathan , Michael J. Trezza, II
发明人: Han Cui , Zhigang Li , Edgar V. Menezes , Aruna Nathan , Michael J. Trezza, II
CPC分类号: A61F9/0017 , A61F9/00772 , A61K9/0051
摘要: The invention provides punctal plugs for the delivery of active agent to one or both of the tear fluid of the eye and to the nasolacrimal duct that comprise a body, at least one cap, and optionally a collarette.
摘要翻译: 本发明提供了用于将活性剂递送到眼睛的泪液和包括身体,至少一个帽和任选的肩胛骨的鼻泪管的一个或两个的泪点。
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公开(公告)号:US08658797B2
公开(公告)日:2014-02-25
申请号:US13404165
申请日:2012-02-24
IPC分类号: C07D211/56 , A61K31/445
CPC分类号: C07D211/58 , A61K31/4468 , A61K31/4525 , A61K31/4545 , A61K31/5375 , C07D211/60 , C07D211/94 , C07D211/96 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general formula (I):
摘要翻译: 公开了用于预防和/或治疗由生长素释放肽受体病理生理介导的疾病的化合物,组合物和方法。 该化合物具有通式(I):
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公开(公告)号:US08524709B2
公开(公告)日:2013-09-03
申请号:US13349222
申请日:2012-01-12
申请人: Congxin Liang , Ming Qi , Shu Gao , Zhigang Li
发明人: Congxin Liang , Ming Qi , Shu Gao , Zhigang Li
IPC分类号: A61K31/5377 , A61K31/404 , A61K31/454 , A61K31/506 , A61K31/4545 , C07D401/14 , C07D413/14 , C07D403/06
CPC分类号: C07D493/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C12Q1/485
摘要: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.
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公开(公告)号:US08513221B2
公开(公告)日:2013-08-20
申请号:US12999032
申请日:2009-07-07
申请人: Congxin Liang , Zhigang Li
发明人: Congxin Liang , Zhigang Li
IPC分类号: C07D413/14
CPC分类号: C07D487/04 , C07D473/32 , C07D519/00
摘要: 2-Morpholin-4-yl-9H-purine and 5-Morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine derivatives, especially those substituted by 6-heteroaryl, are unexpected PI3 kinase isoform selective inhibitors with good drug properties and are useful in treating disorders related to abnormal PI3K activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.
摘要翻译: 2-吗啉-4-基-9H-嘌呤和5-吗啉-4-基-3H- [1,2,3]三唑并[4,5-d]嘧啶衍生物,特别是被6-杂芳基取代的那些,是意想不到的 具有良好药物性质的PI3激酶同种型选择性抑制剂,并且可用于治疗与异常PI3K活性相关的疾病,例如癌症,免疫疾病,心血管疾病,病毒感染,炎症,代谢/内分泌障碍和神经障碍。
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公开(公告)号:US20120312809A1
公开(公告)日:2012-12-13
申请号:US13591041
申请日:2012-08-21
申请人: Shouguo WANG , Zhigang Li , Zongyin Ou , Deqiang Tan
发明人: Shouguo WANG , Zhigang Li , Zongyin Ou , Deqiang Tan
IPC分类号: H05B6/64
CPC分类号: H05B6/6426
摘要: A microwave oven includes an oven seat, an oven cover hinged on the oven seat and a cooking chamber enclosed by the oven seat and oven cover. The oven cover comprises, in this order from an inner side to an outer side, a waterproof cover, a microwave shielding cover and an outer cover that are formed respectively in a hemispherical shape and assembled together via an oven cover skeleton and a skeleton frame. The oven cover skeleton includes an annular base body with an assembly groove to allow the waterproof cover to be wedged therein. The waterproof cover has a first flange to be wedged in the assembly groove. The microwave shielding cover has a second flange to be pressed on the base body. The skeleton frame is coupled on the outer side of the microwave shield cover and pressed on the second flange and oven cover skeleton.
摘要翻译: 微波炉包括烤箱座,铰接在烤箱座上的烤箱盖和由烤箱座和烘箱盖包围的烹饪室。 烤箱盖从内侧到外侧依次包括分别形成为半球状的防水罩,微波屏蔽罩和外盖,并且经由烤箱罩框架和骨架框架组装在一起。 烘箱盖骨架包括具有组装槽的环形基体,以允许防水盖楔入其中。 防水盖具有楔入组装槽中的第一凸缘。 微波屏蔽罩具有被压在基体上的第二凸缘。 骨架框架耦合在微波屏蔽罩的外侧,并被压在第二凸缘和烤箱盖骨架上。
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公开(公告)号:US20110249284A1
公开(公告)日:2011-10-13
申请号:US13045347
申请日:2011-03-10
CPC分类号: G06F17/2705 , G06F3/1206 , G06F3/1208 , G06F3/1244 , G06F3/1245 , G06F3/1246 , G06F3/1257 , G06F17/212 , G06F17/218 , G06F17/2247 , G06F17/245 , G06F17/248
摘要: Disclosed are methods and apparatus for generating accessible documents. In one embodiment, an initial document in a print format is obtained. The print format of the initial document is identified as one of a plurality of print formats. A parser corresponding to the one of the plurality of print formats is applied such that the initial document is parsed according to the print format of the initial document. An intermediate document that conforms to an intermediate format is generated based upon results obtained from applying the parser. A template for converting the intermediate document into an accessible document is obtained. The template is then such that an accessible document corresponding to the initial document is generated, wherein the accessible document includes a plurality of tags that designate an order of a plurality of regions of the accessible document.
摘要翻译: 公开了用于生成可访问文档的方法和装置。 在一个实施例中,获得打印格式的初始文档。 初始文档的打印格式被识别为多种打印格式之一。 应用与多个打印格式之一相对应的解析器,使得根据初始文档的打印格式解析初始文档。 基于从应用解析器获得的结果生成符合中间格式的中间文档。 获得用于将中间文档转换为可访问文档的模板。 模板然后使得生成与初始文档相对应的可访问文档,其中可访问文档包括指定可访问文档的多个区域的顺序的多个标签。
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公开(公告)号:US20110224212A1
公开(公告)日:2011-09-15
申请号:US13108598
申请日:2011-05-16
申请人: Congxin Liang , Ming Qi , Shu Gao , Zhigang Li
发明人: Congxin Liang , Ming Qi , Shu Gao , Zhigang Li
IPC分类号: A61K31/5377 , A61K31/407 , A61K31/454 , A61K31/506 , A61K31/422 , A61P35/00
CPC分类号: C07D493/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C12Q1/485
摘要: The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.
摘要翻译: 本发明涉及化合物,包含该化合物的组合物,以及使用该化合物和化合物组合物的方法。 本文所述的化合物,组合物和方法可用于激酶介导的过程的治疗调节,以及疾病和疾病症状的治疗,特别是由某些激酶的介导的那些症状。
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