公开(公告)号：US07970471B2

公开(公告)日：2011-06-28

申请号：US11776699

申请日：2007-07-12

申请人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

发明人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/18

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/371

摘要： A system and method for automatically selecting among a plurality of pacing modes based upon capture detection. Patients suffering from heart failure may be optimally treated with different resynchronization pacing modes or configurations. By detecting whether capture is being achieved by a particular configuration or mode, a device is able to automatically switch to one that is both optimal in treating the patient and is successful in capturing the heart with pacing pulses.

摘要翻译： 一种用于基于捕获检测在多个起搏模式之间自动选择的系统和方法。 患有心力衰竭的患者可以用不同的再同步起搏模式或配置进行最佳治疗。 通过检测是否通过特定配置或模式实现捕获，设备能够自动切换到在治疗患者时是最佳的并且成功地用起搏脉冲捕获心脏。

公开(公告)号：US20110093031A1

公开(公告)日：2011-04-21

申请号：US12980417

申请日：2010-12-29

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/365

CPC分类号： A61N1/36578 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/3684

摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.

摘要翻译： 公开了用于采用机械测量来同步心室壁位置收缩的方法和装置。 可以放置在电极引线内的加速度计定位在心室壁位置，例如左心室游离壁，右心室游离壁和前壁/隔膜壁。 加速度计响应于心室壁位置的运动产生信号。 然后，处理器可以比较信号以确定心室壁位置收缩的同步的差异。 可以以各种方式确定同步差异，例如计算加速度计信号之间的相位差和/或振幅差。 可以在每个心动周期提供一个或多个刺激脉冲，以重新同步由加速度计测量的收缩，从而不断地和自动地优化心脏再同步治疗。

公开(公告)号：US20090240159A1

公开(公告)日：2009-09-24

申请号：US12476823

申请日：2009-06-02

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61B5/0402

CPC分类号： A61N1/3627 ,  A61N1/36514 ,  A61N1/36542 ,  A61N2001/0585

摘要： Systems and methods for detecting and measuring cardiac contractile function of a heart using an acceleration sensor unit inserted within the heart, such as within a vein of the cardiac wall are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart by inserting and positioning an implantable lead having an electrode near a cardiac wall as well as detecting mechanical events within the patient's heart by then inserting and positioning a cardiac motion sensor unit through the inner lumen of the implantable lead. Furthermore, the systems and methods do not require dedicated leads and may be used with preexisting implantable leads.

摘要翻译： 公开了使用插入心脏内的加速度传感器单元（例如在心脏壁的静脉内）来检测和测量心脏的心脏收缩功能的系统和方法。 该系统和方法涉及通过将具有电极靠近心脏壁的可植入引线插入和定位并且通过插入和定位心脏运动传感器单元来检测患者心脏内的机械事件来检测患者心脏内的电事件的发生 可植入引线的内腔。 此外，系统和方法不需要专用引线，并且可以与预先存在的可植入引线一起使用。

公开(公告)号：US07245970B2

公开(公告)日：2007-07-17

申请号：US11168099

申请日：2005-06-28

申请人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

发明人： Qingsheng Zhu ,  Julio C. Spinelli ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/00

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/371

摘要： A system and method for automatically selecting among a plurality of pacing modes based upon capture detection. Patients suffering from heart failure may be optimally treated with different resynchronization pacing modes or configurations. By detecting whether capture is being achieved by a particular configuration or mode, a device is able to automatically switch to one that is both optimal in treating the patient and is successful in capturing the heart with pacing pulses.

摘要翻译： 一种用于基于捕获检测在多个起搏模式之间自动选择的系统和方法。 患有心力衰竭的患者可以用不同的再同步起搏模式或配置进行最佳治疗。 通过检测是否通过特定配置或模式实现捕获，设备能够自动切换到在治疗患者时是最佳的并且成功地用起搏脉冲捕获心脏。

公开(公告)号：US07127289B2

公开(公告)日：2006-10-24

申请号：US10005092

申请日：2001-12-05

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/368

CPC分类号： A61N1/36578 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/3684

摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.

公开(公告)号：US06980866B2

公开(公告)日：2005-12-27

申请号：US10004686

申请日：2001-12-05

申请人： Nancy Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Nancy Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/365 ,  A61N1/05

CPC分类号： A61N1/3627 ,  A61N1/36514 ,  A61N1/36542 ,  A61N2001/0585

摘要： Systems and methods for detecting and measuring cardiac contractile function of a heart using an acceleration sensor unit inserted within the heart, such as within a vein of the cardiac wall are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart by inserting and positioning an implantable lead having an electrode near a cardiac wall as well as detecting mechanical events within the patient's heart by then inserting and positioning a cardiac motion sensor unit through the inner lumen of the implantable lead. Furthermore, the systems and methods do not require dedicated leads and may be used with preexisting implantable leads.

摘要翻译： 公开了使用插入心脏内的加速度传感器单元（例如在心脏壁的静脉内）来检测和测量心脏的心脏收缩功能的系统和方法。 该系统和方法涉及通过将具有电极靠近心脏壁的可植入引线插入和定位并且通过插入和定位心脏运动传感器单元来检测患者心脏内的机械事件来检测患者心脏内的电事件的发生 可植入引线的内腔。 此外，系统和方法不需要专用引线，并且可以与预先存在的可植入引线一起使用。

公开(公告)号：US20050256542A1

公开(公告)日：2005-11-17

申请号：US11184325

申请日：2005-07-19

申请人： Joseph Pastore ,  Steven Girouard ,  Bruce KenKnight ,  Qingsheng Zhu ,  Jiang Ding

发明人： Joseph Pastore ,  Steven Girouard ,  Bruce KenKnight ,  Qingsheng Zhu ,  Jiang Ding

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3622 ,  A61N1/3627 ,  A61N1/3684

摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

摘要翻译： 心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。 在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

公开(公告)号：US20050240237A1

公开(公告)日：2005-10-27

申请号：US11168099

申请日：2005-06-28

申请人： Qingsheng Zhu ,  Julio Spinelli ,  Jiang Ding ,  Yinghong Yu

发明人： Qingsheng Zhu ,  Julio Spinelli ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/362 ,  A61N1/368 ,  A61N1/37

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/371

摘要： A system and method for automatically selecting among a plurality of pacing modes based upon capture detection. Patients suffering from heart failure may be optimally treated with different resynchronization pacing modes or configurations. By detecting whether capture is being achieved by a particular configuration or mode, a device is able to automatically switch to one that is both optimal in treating the patient and is successful in capturing the heart with pacing pulses.

摘要翻译： 一种用于基于捕获检测在多个起搏模式之间自动选择的系统和方法。 患有心力衰竭的患者可以用不同的再同步起搏模式或配置进行最佳治疗。 通过检测是否通过特定配置或模式实现捕获，设备能够自动切换到在治疗患者时是最佳的并且成功地用起搏脉冲捕获心脏。

公开(公告)号：US07440803B2

公开(公告)日：2008-10-21

申请号：US11264941

申请日：2005-11-02

申请人： Quan Ni ,  Jiang Ding ,  Yinghong Yu ,  Douglas R. Daum ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

发明人： Quan Ni ,  Jiang Ding ,  Yinghong Yu ,  Douglas R. Daum ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

摘要翻译： 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

公开(公告)号：US20090048637A1

公开(公告)日：2009-02-19

申请号：US12254631

申请日：2008-10-20

申请人： Quan Ni ,  Jiang Ding ,  Yinghong Yu ,  Douglas R. Daum ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

发明人： Quan Ni ,  Jiang Ding ,  Yinghong Yu ,  Douglas R. Daum ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

摘要翻译： 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量峰 - 峰体积或最大心室容积变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。