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公开(公告)号：US07412332B1
公开(公告)日：2008-08-12
申请号：US09557997
申请日：2000-04-24
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： A data structure, tangibly embodied in a computer-readable medium, representing a polymer of chemical units is disclosed. The data structure includes an identifier including a plurality of fields for storing values corresponding to properties of the polymer. The polymer may, for example, be a polysaccharide and the chemical units may be saccharides. Also disclosed is a computer-implemented method for determining whether properties of a query sequence of chemical units match properties of a polymer of chemical units. The query sequence is represented by a first data structure, and the polymer is represented by a second data structure, each are tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the query sequence and polymer, respectively. The invention also involves a notational system referred to as Property Encoded Nomenclature.
摘要翻译： 公开了一种有形地体现在表示化学单元的聚合物的计算机可读介质中的数据结构。 数据结构包括标识符，其包括用于存储与聚合物的性质对应的值的多个场。 聚合物可以是例如多糖，化学单元可以是糖。 还公开了一种用于确定化学单元的查询序列的属性是否与化学单元的聚合物的性质匹配的计算机实现的方法。 查询序列由第一数据结构表示，并且聚合物由第二数据结构表示，每个数据结构都有形地体现在计算机可读介质中，包括包括多个位字段的标识符，用于存储对应于 查询序列和聚合物。 本发明还涉及称为属性编码术语的符号系统。
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公开(公告)号：US07110889B2
公开(公告)日：2006-09-19
申请号：US10760133
申请日：2004-01-16
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
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33.发明授权公开(公告)号：US06962699B2
公开(公告)日：2005-11-08
申请号：US10454816
申请日：2003-06-03
申请人： Kevin Pojasek , Rahul Raman , Ram Sasisekharan
发明人： Kevin Pojasek , Rahul Raman , Ram Sasisekharan
CPC分类号： C08B37/0069 , A61K38/00 , C12N9/88 , C12Q1/527
摘要： The invention relates to rationally designed polysaccharide lyases and uses thereof. In particular, the invention relates to modified chondroitinase B. The modified chondroitinase B enzymes of the invention are useful for a variety of purposes, including cleaving and sequencing polysaccharides such as glycosaminoglycans (GAGs) as well as removing polysaccharides from a solution. The invention also includes methods of inhibiting anticoagulant activity, inhibiting angiogenesis, treating cancer, and inhibiting maternal malarial infection.
摘要翻译： 本发明涉及合理设计的多糖裂解酶及其用途。 特别地，本发明涉及修饰的软骨素酶B.本发明的修饰的软骨素酶B可用于多种目的，包括切割和测序多糖如糖胺聚糖（GAG），以及从溶液中除去多糖。 本发明还包括抑制抗凝血活性，抑制血管生成，治疗癌症和抑制产妇疟疾感染的方法。
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公开(公告)号：US08338119B2
公开(公告)日：2012-12-25
申请号：US11638318
申请日：2006-12-13
申请人： Vikas Prabhakar , Ishan Capila , Rahul Raman , Carlos Bosques , Kevin Pojasek , Ram Sasisekharan
发明人： Vikas Prabhakar , Ishan Capila , Rahul Raman , Carlos Bosques , Kevin Pojasek , Ram Sasisekharan
CPC分类号： C12N9/88 , A61K38/47 , Y02A50/411
摘要： The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.
摘要翻译： 本发明涉及软骨素酶ABCⅠ及其用途。 特别地，本发明涉及重组和修饰的软骨素酶ABCⅠ，其生产及其用途。 本发明的软骨素酶ABC I酶可用于多种目的，包括降解和分析多糖如糖胺聚糖（GAG）。 这些GAG可以包括硫酸软骨素，硫酸皮肤素，未硫酸化的软骨素和透明质酸。 软骨素酶ABC I酶也可用于促进神经再生，促进中风恢复，治疗脊髓损伤，治疗上皮疾病，治疗感染和治疗癌症等治疗方法。
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公开(公告)号：US08018231B2
公开(公告)日：2011-09-13
申请号：US12774335
申请日：2010-05-05
申请人： Ram Sasisekharan , Ganesh Venkataraman , Rahul Raman , Benito Casu , Giangiacomo Torri , Marco Guerrini
发明人： Ram Sasisekharan , Ganesh Venkataraman , Rahul Raman , Benito Casu , Giangiacomo Torri , Marco Guerrini
IPC分类号： G01V3/00
CPC分类号： G01N24/08 , Y10T436/143333
摘要： The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.
摘要翻译： 本发明涉及多糖分析方法。 特别地，衍生出关于多糖的组成和序列信息。 一些方法使用NMR结合另一种实验方法，例如用于分析的毛细管电泳技术。
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公开(公告)号：US20070224670A1
公开(公告)日：2007-09-27
申请号：US11638287
申请日：2006-12-13
申请人： Vikas Prabhakar , Ishan Capila , Rahul Raman , Carlos Bosques , Kevin Pojasek , Ram Sasisekharan
发明人： Vikas Prabhakar , Ishan Capila , Rahul Raman , Carlos Bosques , Kevin Pojasek , Ram Sasisekharan
IPC分类号： C12N9/00
CPC分类号： C12N9/88 , A61K38/47 , Y02A50/411
摘要： The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.
摘要翻译： 本发明涉及软骨素酶ABCⅠ及其用途。 特别地，本发明涉及重组和修饰的软骨素酶ABCⅠ，其生产及其用途。 本发明的软骨素酶ABC I酶可用于多种目的，包括降解和分析多糖如糖胺聚糖（GAG）。 这些GAG可以包括硫酸软骨素，硫酸皮肤素，未硫酸化的软骨素和透明质酸。 软骨素酶ABC I酶也可用于促进神经再生，促进中风恢复，治疗脊髓损伤，治疗上皮疾病，治疗感染和治疗癌症等治疗方法。
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公开(公告)号：US20070148740A1
公开(公告)日：2007-06-28
申请号：US11638318
申请日：2006-12-13
申请人： Vikas Prabhakar , Ishan Capila , Rahul Raman , Carlos Bosques , Kevin Pojasek , Ram Sasisekharan
发明人： Vikas Prabhakar , Ishan Capila , Rahul Raman , Carlos Bosques , Kevin Pojasek , Ram Sasisekharan
CPC分类号： C12N9/88 , A61K38/47 , Y02A50/411
摘要： The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.
摘要翻译： 本发明涉及软骨素酶ABCⅠ及其用途。 特别地，本发明涉及重组和修饰的软骨素酶ABCⅠ，其生产及其用途。 本发明的软骨素酶ABC I酶可用于多种目的，包括降解和分析多糖如糖胺聚糖（GAG）。 这些GAG可以包括硫酸软骨素，硫酸皮肤素，未硫酸化的软骨素和透明质酸。 软骨素酶ABC I酶也可用于促进神经再生，促进中风恢复，治疗脊髓损伤，治疗上皮疾病，治疗感染和治疗癌症等治疗方法。
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公开(公告)号：US20070148157A1
公开(公告)日：2007-06-28
申请号：US11638178
申请日：2006-12-13
申请人： Vikas Prabhakar , Ishan Capila , Rahul Raman , Carlos Bosques , Kevin Pojasek , Ram Sasisekharan
发明人： Vikas Prabhakar , Ishan Capila , Rahul Raman , Carlos Bosques , Kevin Pojasek , Ram Sasisekharan
CPC分类号： C12N9/88 , A61K38/47 , Y02A50/411
摘要： The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.
摘要翻译： 本发明涉及软骨素酶ABCⅠ及其用途。 特别地，本发明涉及重组和修饰的软骨素酶ABCⅠ，其生产及其用途。 本发明的软骨素酶ABC I酶可用于各种目的，包括降解和分析多糖如糖胺聚糖（GAG）。 这些GAG可以包括硫酸软骨素，硫酸皮肤素，未硫酸化的软骨素和透明质酸。 软骨素酶ABC I酶也可用于促进神经再生，促进中风恢复，治疗脊髓损伤，治疗上皮疾病，治疗感染和治疗癌症等治疗方法。
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39.发明申请公开(公告)号：US20070065424A1
公开(公告)日：2007-03-22
申请号：US11518389
申请日：2006-09-08
申请人： Kevin Pojasek , Rahul Raman , Ram Sasisekharan
发明人： Kevin Pojasek , Rahul Raman , Ram Sasisekharan
CPC分类号： C08B37/0069 , A61K38/00 , C12N9/88 , C12Q1/527
摘要： The invention relates to rationally designed polysaccharide lyases and uses thereof. In particular, the invention relates to modified chondroitinase B. The modified chondroitinase B enzymes of the invention are useful for a variety of purposes, including cleaving and sequencing polysaccharides such as glycosaminoglycans (GAGs) as well as removing polysaccharides from a solution. The invention also includes methods of inhibiting anticoagulant activity, inhibiting angiogenesis, treating cancer, and inhibiting maternal malarial infection.
摘要翻译： 本发明涉及合理设计的多糖裂解酶及其用途。 特别地，本发明涉及修饰的软骨素酶B.本发明的修饰的软骨素酶B可用于多种目的，包括切割和测序多糖如糖胺聚糖（GAG），以及从溶液中除去多糖。 本发明还包括抑制抗凝血活性，抑制血管生成，治疗癌症和抑制产妇疟疾感染的方法。
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公开(公告)号：US07139666B2
公开(公告)日：2006-11-21
申请号：US10356349
申请日：2003-01-31
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
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