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公开(公告)号：US20120135006A1
公开(公告)日：2012-05-31
申请号：US13279592
申请日：2011-10-24
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/1027 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： Ultra high affinity antibodies with binding affinities in the range of 1010 M−1, and even 1011 M−1 are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and/or treat disease, especially virus-induced diseases, are also disclosed.
摘要翻译： 公开了具有1010M-1甚至1011M-1范围内的结合亲和力的超高亲和力抗体。 此类抗体包括具有新型高亲和力互补决定区（CDR）的抗体，特别是具有来自人或小鼠的骨架和恒定区的抗体。 还公开了制备和筛选这些抗体的方法，以及使用它们来预防和/或治疗疾病，特别是病毒诱导的疾病的方法。
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公开(公告)号：US07115716B2
公开(公告)日：2006-10-03
申请号：US10300675
申请日：2002-11-19
申请人： Jeffry D. Watkins
发明人： Jeffry D. Watkins
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , A61K2039/505 , A61K2039/5152 , C07K16/3015 , C07K2317/55 , C07K2317/565 , C07K2317/77
摘要： The invention provides tumor-specific human monoclonal antibodies and functional fragments. Also provided are nucleic acids encoding tumor-specific human monoclonal antibodies and functional fragments. A method for reducing neoplastic cell proliferation is also provided. The method consists of administering an effective amount of a tumor-specific human monoclonal antibody or functional fragment. Also provided is a method of detecting a neoplastic cell in a sample. The method consists of contacting a cell with a tumor-specific monoclonal antibody or functional fragment and detecting the specific binding of the human monoclonal antibody or functional fragment to the sample.
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公开(公告)号：US06348194B1
公开(公告)日：2002-02-19
申请号：US08555684
申请日：1995-11-13
申请人： William D. Huse , Jeffry D. Watkins
发明人： William D. Huse , Jeffry D. Watkins
IPC分类号： A61K39395
CPC分类号： C07K16/30 , C07K16/28 , C07K16/40 , C07K2317/77
摘要： The invention provides a method of reducing the proliferation of a neoplastic cell. The method consists of contacting the neoplastic cell with a cytotoxic or cytostatic binding agent specifically reactive with an aberrantly expressed vesicular membrane associated neoplastic cell specific internalizing antigen. The neoplastic cell specific internalizing anitgen can be selected from the group consisting of lamp-2 and limp II families of lysosomal integral membrane proteins. Also provided is a method of intracellular targeting of a cytotoxic or cytostatic agent to a neoplastic cell population. The method consists of administering to an individual containing a neoplastic cell population a cytotoxic or cytostatic binding agent specifically reactive with an aberrantly expressed vesicular membrane associated neoplastic cell specific internalizing antigen that is expressed by the neoplastic cell population, wherein the cytotoxic or cytostatic binding agent is bound by the neoplastic cell specific internalizing antigen and is internalized into the intracellular compartment. A method of reducing tumor growth through the intracellular targeting of a cytotoxic agent is also provided.
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公开(公告)号：US08153133B2
公开(公告)日：2012-04-10
申请号：US12707527
申请日：2010-02-17
IPC分类号： A61K39/42
CPC分类号： C07K16/1027 , A61K2039/505 , C07K16/00 , C07K2317/567
摘要： High potency antibodies, including immunologically active fragments thereof, having high kinetic association rate constants and optional high affinities are disclosed, along with methods for producing such antibodies. The high potency antibodies disclosed herein are of either the neutralizing or non-neutralizing type and have specificity for antigens displayed by microorganisms, especially viruses, as well as antigenic sites present on cancer cells and on various types of toxins, and the products of toxins. Processes for producing high potency neutralizing antibodies and increasing the potency of already existing neutralizing antibodies are also described. Methods of using said antibodies in the prevention and/or treatment of diseases, especially diseases induced or caused by viruses, are disclosed.
摘要翻译： 公开了具有高动力学关联速率常数和任选的高亲和力的高效力抗体，包括其免疫活性片段，以及产生此类抗体的方法。 本文公开的高效力抗体是中和或非中和型，并且对由微生物，特别是病毒以及存在于癌细胞和各种类型毒素上的抗原位点以及毒素产物显示的抗原具有特异性。 还描述了用于产生高效中和抗体并增加已经存在的中和抗体的效力的方法。 公开了在预防和/或治疗疾病，特别是由病毒引起或引起的疾病中使用所述抗体的方法。
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公开(公告)号：US20100266614A1
公开(公告)日：2010-10-21
申请号：US12777814
申请日：2010-05-11
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/1027 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： Ultra high affinity antibodies with binding affinities in the range of 1010 M−1, and even 1011 M−1 are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and/or treat disease, especially virus-induced diseases, are also disclosed.
摘要翻译： 公开了具有1010M-1甚至1011M-1范围内的结合亲和力的超高亲和力抗体。 此类抗体包括具有新型高亲和力互补决定区（CDR）的抗体，特别是具有来自人或小鼠的骨架和恒定区的抗体。 还公开了制备和筛选这些抗体的方法，以及使用它们来预防和/或治疗疾病，特别是病毒诱导的疾病的方法。
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公开(公告)号：US07566770B2
公开(公告)日：2009-07-28
申请号：US11486894
申请日：2006-07-14
申请人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人： Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： The invention provides an antibody, or functional fragment thereof, a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
摘要翻译： 本发明提供抗体或其功能片段，其接枝抗体或其功能片段，其包含在重链CDR的一个或多个CDR中具有至少一个氨基酸取代的一个或多个互补决定区（CDR），其中 抗体或其功能片段对隐窝胶原表位具有特异性结合活性。 本发明还提供了使用具有对神经胶原表位具有特异性结合活性的抗体的方法，包括抑制血管发生，肿瘤生长和转移的方法。
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公开(公告)号：US07435799B2
公开(公告)日：2008-10-14
申请号：US10541260
申请日：2004-01-08
CPC分类号： C07K16/241 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to TNF-α binding molecules and nucleic acid sequences encoding TNF-α binding molecules. In particular, the present invention relates to TNF-α binding molecules with a high binding affinity, a high association rate, a low dissociation rate with regard to human TNF-α and that are capable of neutralizing TNF-α at low concentrations. Preferably, the TNF-α binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).
摘要翻译： 本发明涉及TNF-α结合分子和编码TNF-α结合分子的核酸序列。 特别地，本发明涉及具有高结合亲和力，高缔合率，相对于人TNF-α的低解离速率且能够以低浓度中和TNF-α的TNF-α结合分子。 优选地，本发明的TNF-α结合分子包含具有完全人框架（例如人种系框架）的轻链和/或重链可变区。
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38.发明授权Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use 失效丁酰胆碱酯酶多肽具有增加的催化效率和使用方法公开(公告)号：US06989261B2
公开(公告)日：2006-01-24
申请号：US10413432
申请日：2003-04-11
CPC分类号： C12N9/18 , A61K38/00 , C12Y301/01008
摘要： The invention provides a butyrylcholinesterase variant having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acid. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition with the invention variant.
摘要翻译： 本发明提供了具有增加的可卡因水解活性的丁酰胆碱酯酶变体以及相应的编码核酸。 本发明还提供了水解可卡因类丁酰胆碱酯酶底物的方法以及用本发明变体治疗可卡因诱导病症的方法。
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公开(公告)号：US06787638B1
公开(公告)日：2004-09-07
申请号：US09203768
申请日：1998-12-02
申请人： Jeffry D. Watkins , William D. Huse
发明人： Jeffry D. Watkins , William D. Huse
IPC分类号： C07K1600
CPC分类号： C07K16/3069 , A61K47/6851 , A61K2039/505 , C07K16/3015 , C07K16/3023 , C07K2317/21 , C07K2317/565
摘要： The invention provides tumor-specific human monoclonal antibodies and functional fragments. Also provided are nucleic acids encoding tumor-specific human monoclonal antibodies and functional fragments. A method for reducing neoplastic cell proliferation is also provided. The method consists of administering an effective amount of a tumor-specific human monoclonal antibody or functional fragment. Also provided is a method of detecting a neoplastic cell in a sample. The method consists of contacting a cell with a tumor-specific monoclonal antibody or functional fragment and detecting the specific binding of the human monoclonal antibody or functional fragment to the sample.
摘要翻译： 本发明提供肿瘤特异性人单克隆抗体和功能片段。 还提供了编码肿瘤特异性人单克隆抗体和功能片段的核酸。 还提供了减少肿瘤细胞增殖的方法。 该方法包括施用有效量的肿瘤特异性人单克隆抗体或功能片段。 还提供了检测样品中的肿瘤细胞的方法。 该方法包括使细胞与肿瘤特异性单克隆抗体或功能片段接触并检测人单克隆抗体或功能片段与样品的特异性结合。
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公开(公告)号：US06656467B2
公开(公告)日：2003-12-02
申请号：US09771415
申请日：2001-01-26
IPC分类号： A61K3942
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/1027 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： Ultra high affinity antibodies with binding affinities in the range of 1010 M−1, and even 1011 M−1 are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and/or treat disease, especially virus-induced diseases, are also disclosed.
摘要翻译： 公开了具有10 10 M -1，甚至10 11 M -1范围内的结合亲和力的超高亲和力抗体。 此类抗体包括具有新型高亲和力互补决定区（CDR）的抗体，特别是具有来自人或小鼠的骨架和恒定区的抗体。 还公开了制备和筛选这些抗体的方法，以及使用它们来预防和/或治疗疾病，特别是病毒诱导的疾病的方法。
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