公开(公告)号：US20110194431A1

公开(公告)日：2011-08-11

申请号：US12998364

申请日：2009-10-20

Applicant: He Yong ,  Xiao-Jun Ma ,  Jian Ping Song ,  Guang Hua Zhou ,  Jun Li

Inventor： He Yong ,  Xiao-Jun Ma ,  Jian Ping Song ,  Guang Hua Zhou ,  Jun Li

IPC: H04W74/08

CPC classification number: H04W74/085

Abstract: In the context of IEEE 802.11 WLAN networks, enhancement to the Relaxed Deterministic Backoff (R-DEB) for random access of shared (Medium Access Control MAC) method. For all available candidate resource slots, a busy index is calculated that reflects the level of use/occupation in the past and infers a probability of use in the future by another concurring device. The method assumes the use of a sub-set of resource slots for transmission, and updates this set by replacing resource slots for which collisions are frequent with a not currently used candidate resource for which the busy index is the lowest. Passive Spoofing/overhearing of all resources for clear channel assessment (CCS) is used for resource monitoring purposes.

Abstract translation: 在IEEE 802.11 WLAN网络的上下文中，对用于共享（媒体访问控制MAC）方法的随机接入的轻松确定性后退（R-DEB）的增强。 对于所有可用的候选资源时隙，计算反映过去使用/占用水平的繁忙索引，并推测未来由另一个同步设备使用的概率。 该方法假设使用资源时隙子集进行传输，并通过将忙碌索引最低的未使用的候选资源替换为频繁冲突的资源时隙来更新该集合。 用于明确渠道评估（CCS）的所有资源的被动欺骗/监听被用于资源监控。

公开(公告)号：US20110136680A1

公开(公告)日：2011-06-09

申请号：US12718973

申请日：2010-03-06

Applicant: Mark G. Erlander ,  Xiao-Jun Ma ,  Dennis Sgroi

Inventor： Mark G. Erlander ,  Xiao-Jun Ma ,  Dennis Sgroi

IPC: C12Q1/68 ,  C40B30/00

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112

Abstract: The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to cancer. In particular, the disclosure includes the identities of genes that are expressed in correlation with tumor grade. The levels of gene expression are disclosed as a molecular index for determining tumor grade in a patient and predicting clinical outcome, and so prognosis, for the patient. The molecular grading of cancer may optionally be used in combination with a second molecular index for diagnosing cancer and its prognosis. The disclosure further includes methods for predicting cancer recurrence, and/or predicting occurrence of metastatic cancer. For diagnosis or prognosis, the disclosure further includes methods for determining or selecting the treatment of cancer based upon the likelihood of life expectancy, cancer recurrence, and/or cancer metastasis.

Abstract translation: 该公开内容包括鉴定和使用与癌症具有临床相关性的基因表达谱或模式。 特别地，本公开包括与肿瘤等级相关表达的基因的身份。 公开了基因表达水平作为确定患者肿瘤分级的分子指标，并预测了患者的临床结果以及预后。 癌症的分子分级可以任选地与用于诊断癌症及其预后的第二分子指数组合使用。 本公开还包括用于预测癌症复发和/或预测转移性癌症发生的方法。 为了诊断或预后，本公开还包括基于预期寿命，癌症复发和/或癌症转移的可能性来确定或选择癌症治疗的方法。

公开(公告)号：US20100135167A1

公开(公告)日：2010-06-03

申请号：US12452161

申请日：2007-06-22

Applicant: Xiao-Jun Ma ,  Yong He ,  Zhigang Zhang ,  Huanqiang Zhang ,  Jun Li ,  Charles Chunaming Wang

Inventor： Xiao-Jun Ma ,  Yong He ,  Zhigang Zhang ,  Huanqiang Zhang ,  Jun Li ,  Charles Chunaming Wang

IPC: H04L12/26 ,  H04J3/02

CPC classification number: H04W74/085

Abstract: A method and apparatus are described for gaining access to a communication medium in a contention-based network, including determining a slot count based on a number of stations in the contention-based network, adjusting the slot count, initiating a frame transmission when the slot count reaches a predetermined value and wherein said number of stations and an address queue are adjusted to reflect a priority. Further, a method and apparatus are described for gaining access to a communication medium in a contention-based network, including receiving a slot count based on a number of stations in the contention-based network, adjusting the slot count, initiating a frame transmission when the slot count reaches a predetermined value and wherein said number of stations and an address queue are adjusted to reflect a priority.

Abstract translation: 描述了一种用于在基于竞争的网络中获取对通信介质的访问的方法和装置，包括基于在基于竞争的网络中的站数量来确定时隙计数，调整时隙计数，当时隙发起帧传输 计数达到预定值，并且其中调整所述站数和地址队列以反映优先级。 此外，描述了一种用于在基于竞争的网络中获取对通信介质的访问的方法和装置，包括基于在基于竞争的网络中的站点数目接收时隙计数，调整时隙计数，启动帧传输， 时隙计数达到预定值，并且其中所述站数和地址队列被调整以反映优先级。

公开(公告)号：US20090270271A1

公开(公告)日：2009-10-29

申请号：US12210807

申请日：2008-09-15

Applicant: Mark G. Erlander ,  Xiao-Jun Ma ,  Thomas Baer

Inventor： Mark G. Erlander ,  Xiao-Jun Ma ,  Thomas Baer

IPC: C40B30/04

CPC classification number: C12Q1/6876 ,  C12Q1/6809 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2565/501

Abstract: The invention provides materials and methods for the detection of nucleic acid expression via the 3′ portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3′ end of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3′ end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a “transcriptome”).

Abstract translation: 本发明提供了通过表达序列的3'部分检测核酸表达的材料和方法。 本发明的实施方案包括使用包含与表达的序列的3'末端互补的核酸探针的微阵列，以及通过使用基于定量PCR（Q-PCR）的扩增在3'末端发现的序列的表达 序列。 本发明可用于检测编码特定基因产物（“转录组”中存在的序列）的表达的核酸的存在。

公开(公告)号：US20090215037A1

公开(公告)日：2009-08-27

申请号：US11816623

申请日：2006-02-16

Applicant: Xiao-Jun Ma ,  Xianqun Wang ,  Mark G. Erlander

Inventor： Xiao-Jun Ma ,  Xianqun Wang ,  Mark G. Erlander

IPC: C12Q1/68 ,  C40B40/06

CPC classification number: G16B25/00 ,  C12Q1/6837 ,  C12Q1/6886 ,  G16B40/00

Abstract: This invention relates to the identification and use of a subset of transcribed genes, wherein the expression of genes in the subset are able to classify cells among a plurality of classes. Methods for the identification or selection of such subsets are provided, along with computer implemented means for the application of the methods. The invention further provides physical embodiments based on the gene sequences of the subsets as well as methods for the use of the identified sets of gene sequences to classify a cell or tissue sample.

Abstract translation: 本发明涉及鉴定和使用转录基因子集，其中该子集中基因的表达能够对多个类别之间的细胞进行分类。 提供了用于识别或选择这些子集的方法，以及用于应用方法的计算机实现的方法。 本发明还提供了基于子集的基因序列的物理实施方案以及使用所鉴定的基因序列集合来分类细胞或组织样品的方法。

公开(公告)号：US07504214B2

公开(公告)日：2009-03-17

申请号：US10727100

申请日：2003-12-02

Applicant: Mark G. Erlander ,  Xiao-Jun Ma ,  Dennis C. Sgroi

Inventor： Mark G. Erlander ,  Xiao-Jun Ma ,  Dennis C. Sgroi

IPC: C12Q1/68 ,  C07H21/04

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/158

Abstract: Methods and compositions are provided for the identification of expression signatures in ER+ breast cancer cases, where the signatures correlate with responsiveness, or lack thereof, to tamoxifen treatment. The signature profiles are identified based upon sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for predicting the efficacy of treating a subject with ER+ breast cancer with tamoxifen. Additional methods and compositions are provided for predicting tamoxifen responsiveness in cases of ER+ breast cancer by use of three biomarkers. Two biomarkers display increased expression correlated with tamoxifen response while the third biomarker displays decreased expression correlated with tamoxifen response.

Abstract translation: 提供方法和组合物用于鉴定ER +乳腺癌病例中的表达标志，其中签名与他莫昔芬治疗的反应性或缺乏相关。 基于来自乳腺癌独立病例的参考乳腺组织样本的抽样来鉴定特征谱，并提供可靠的一组分子标准，用于预测使用他莫昔芬治疗患有ER +乳腺癌的受试者的功效。 提供了另外的方法和组合物，用于通过使用三种生物标志物来预测ER +乳腺癌患者中的他莫昔芬反应性。 两种生物标志物显示与他莫昔芬反应相关的增加的表达，而第三种生物标志物显示与他莫昔芬反应相关的降低的表达。