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公开(公告)号:US06956036B1
公开(公告)日:2005-10-18
申请号:US10221400
申请日:2000-11-14
申请人: Jesse A. May , Zixia Feng , Anura P. Dantanarayana
发明人: Jesse A. May , Zixia Feng , Anura P. Dantanarayana
IPC分类号: A61K31/416 , A61K31/5375 , C07D231/56 , C07D413/04
CPC分类号: C07D413/04 , C07D231/56
摘要: Substituted 1-(α-alkyl-ethylamino)-1H-indazol-6-ols useful for lowering and controlling IOP and treating glaucoma are disclosed
摘要翻译: 公开了用于降低和控制IOP和治疗青光眼的取代的1-(α-烷基 - 乙基氨基)-1H-吲唑-6-醇
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公开(公告)号:US06881749B2
公开(公告)日:2005-04-19
申请号:US10722042
申请日:2003-11-24
申请人: Hwang-Hsing Chen , Jesse A. May , Bryon S. Severns
发明人: Hwang-Hsing Chen , Jesse A. May , Bryon S. Severns
IPC分类号: C07D491/052 , A61K31/416 , A61K31/4162 , A61P27/02 , A61P27/06 , A61P43/00 , C07D487/04 , C07D491/04 , C07D491/048 , C07D491/02
CPC分类号: C07D491/04 , C07D487/04
摘要: Pyranoindazoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.
摘要翻译: 吡喃并吲唑被公开。 还公开了降低和控制正常或升高的眼内压的方法以及使用含有一种或多种本发明化合物的组合物治疗青光眼的方法。
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33.
公开(公告)号:US5650541A
公开(公告)日:1997-07-22
申请号:US583928
申请日:1996-01-11
申请人: Jesse A. May
发明人: Jesse A. May
IPC分类号: A61K31/138 , C07C217/18 , C07C217/20 , C07C217/32 , C07D265/32 , C07D295/092 , C07C381/04 , C07C213/00
CPC分类号: C07D295/088 , A61K31/138 , A61K31/5375 , C07C217/18 , C07C217/20 , C07C217/32 , C07D265/32 , Y10S514/913
摘要: Compounds structurally related to ethacrynic acid are described. The compounds are useful for controlling intraocular pressure. Unlike ethacrynic acid, the compounds of the present invention are capable of effectively penetrating the cornea. Methods of controlling intraocular pressure via topical application of one or more of the compounds to the eye and topical ophthalmic compositions useful in the treatment of glaucoma are also described.
摘要翻译: 描述了与ethacrynic酸结构相关的化合物。 该化合物可用于控制眼内压。 不同于乙酸,本发明的化合物能够有效地穿透角膜。 还描述了通过将一种或多种化合物局部施用于眼睛和用于治疗青光眼的局部眼用组合物来控制眼内压的方法。
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34.
公开(公告)号:US5506226A
公开(公告)日:1996-04-09
申请号:US49215
申请日:1993-04-19
申请人: Jesse A. May
发明人: Jesse A. May
IPC分类号: A61K31/138 , C07C217/18 , C07C217/20 , C07C217/32 , C07D265/32 , C07D295/092 , A61K31/55 , A61K31/075 , A61K31/535
CPC分类号: C07D295/088 , A61K31/138 , A61K31/5375 , C07C217/18 , C07C217/20 , C07C217/32 , C07D265/32 , Y10S514/913
摘要: Compounds structurally related to ethacrynic acid are described. The compounds are useful for controlling intraocular pressure. Unlike ethacrynic acid, the compounds of the present invention are capable of effectively penetrating the cornea. Methods of controlling intraocular pressure via topical application of one or more of the compounds to the eye and topical ophthalmic compositions useful in the treatment of glaucoma are also described.
摘要翻译: 描述了与ethacrynic酸结构相关的化合物。 该化合物可用于控制眼内压。 不同于乙酸,本发明的化合物能够有效地穿透角膜。 还描述了通过将一种或多种化合物局部施用于眼睛和用于治疗青光眼的局部眼用组合物来控制眼内压的方法。
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