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公开(公告)号：US09751830B2
公开(公告)日：2017-09-05
申请号：US13634368
申请日：2011-03-07
IPC分类号： C07C233/25 , A61K31/075 , C07C217/18 , C07C217/20 , C07C233/18 , C07C217/32
CPC分类号： C07C233/25 , A61K31/075 , C07C217/18 , C07C217/20 , C07C217/32 , C07C233/18
摘要： The present invention relates to compounds of formula (I) that are inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-α mediated conditions: Formula (I)
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公开(公告)号：US08980950B2
公开(公告)日：2015-03-17
申请号：US14069447
申请日：2013-11-01
申请人： GlaxoSmithKline, LLC
IPC分类号： A61K31/195 , C07C229/00 , C07C229/34 , C07C217/30 , C07C217/32 , C07C217/34 , C07C217/54
CPC分类号： C07C217/54 , C07C217/30 , C07C217/32 , C07C217/34 , C07C229/34 , C07C2602/08
摘要： Novel calcilytic compounds and methods of using them are provided.
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公开(公告)号：US08586631B2
公开(公告)日：2013-11-19
申请号：US13764126
申请日：2013-02-11
申请人： GlaxoSmithKline, LLC
IPC分类号： A61K31/24 , C07C229/00
CPC分类号： C07C217/54 , C07C217/30 , C07C217/32 , C07C217/34 , C07C229/34 , C07C2602/08
摘要： Novel calcilytic compounds and methods of using them are provided.
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公开(公告)号：US20110118469A1
公开(公告)日：2011-05-19
申请号：US12939516
申请日：2010-11-04
IPC分类号： C07D215/227 , C07C213/02 , C07D209/08
CPC分类号： C07C213/04 , B01J19/0093 , B01J2219/00788 , B01J2219/0081 , B01J2219/00828 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00952 , C07C2601/14 , C07C2602/08 , C07D209/08 , C07D215/26 , C07C215/30 , C07C215/44 , C07C217/30 , C07C217/32
摘要： The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.
摘要翻译： 本发明提供了在微反应器环境中合成化学物质的各种方法。 在某些情况下，本发明的反应产物可能作为药物和聚合物研究中的中间体和/或产品是有价值的。 例如，该方法可以涉及在微通道内合成氨基醇。 本文描述的实施方案可以允许具有显着更短的反应时间和提高效率的反应。
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公开(公告)号：US5034535A
公开(公告)日：1991-07-23
申请号：US529712
申请日：1990-05-30
IPC分类号： C07B43/04 , C07B53/00 , C07B57/00 , C07C213/02 , C07C213/06 , C07C213/10 , C07C217/32 , C07C217/34 , C07D263/18 , C07D263/20 , C07D263/24
CPC分类号： C07D263/24 , C07C213/06 , C07C217/32
摘要： A process for preparing S-metoprolol of the formula ##STR1## or a salt thereof, with high enantiomeric purity, is described, whereby a (S)-5-hydroxymethyl-3-isopropyloxazolidin-2-one sulfonic acid ester of the formula ##STR2## is prepared, and further reacted with 4-[2-methoxyethyl]phenol of the formula ##STR3## and the resulting intermediate of the formula ##STR4## is hydrolysed to S-metoprolol, and whereby the (S)-5-hydroxymethyl-3-isopropyloxazolidin-2-one sulfonic acid ester of formula II is prepared by reacting (S)-3-isopropylamino-1,2-propanediol of the formula ##STR5## with a chloroformic acid ester of the formula ##STR6## wherein R' is an alkyl group having 1-3 carbon atoms or a phenyl group, to the formation of (S)-5-hydroxymethyl-3-isopropyloxazolidin-2-one of the formula ##STR7## which is reacted with an activated sulfonic acid of the formula ##STR8## wherein R" is an aryl group such as tolyl and X is a halogen such as Cl, to formation of the ester of formula II, which when required is enriched with the (S)-enantiomer by crystallization.
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公开(公告)号：US20180215863A1
公开(公告)日：2018-08-02
申请号：US15746529
申请日：2016-08-04
申请人： SIKA TECHNOLOGY AG
发明人： Urs BURCKHARDT , Ursula STADELMANN , Andreas KRAMER , Edis KASEMI
IPC分类号： C08G59/50 , C07C217/32 , C08G59/56 , C09D163/00
CPC分类号： C08G59/504 , C07C217/32 , C07C217/34 , C08G59/50 , C08G59/56 , C09D163/00
摘要： An amine of formula (I) in a curing agent for epoxy resins, a curing agent for epoxy resins containing the amine of formula (I) and resultant epoxy resin compositions which can be used particularly as low-emission room-temperature-curing epoxy resin coatings demonstrating good workability, rapid curing, a high degree of hardness and high surface quality. The amine of formula (I) is low-odour, can be handled well at room temperature even without dilution, and can be produced at high purity in a simple process.
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公开(公告)号：US20140057980A1
公开(公告)日：2014-02-27
申请号：US14069447
申请日：2013-11-01
申请人： GlaxoSmithKline, LLC
IPC分类号： C07C229/34
CPC分类号： C07C217/54 , C07C217/30 , C07C217/32 , C07C217/34 , C07C229/34 , C07C2602/08
摘要： Novel calcilytic compounds and methods of using them are provided.
摘要翻译： 提供新的钙质化合物及其使用方法。
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公开(公告)号：US20130158114A1
公开(公告)日：2013-06-20
申请号：US13764126
申请日：2013-02-11
申请人： GlaxoSmithKline, LLC
IPC分类号： C07C217/54
CPC分类号： C07C217/54 , C07C217/30 , C07C217/32 , C07C217/34 , C07C229/34 , C07C2602/08
摘要： Novel calcilytic compounds and methods of using them are provided.
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公开(公告)号：US20110054021A1
公开(公告)日：2011-03-03
申请号：US12894644
申请日：2010-09-30
IPC分类号： A61K31/216 , A61K31/195 , A61P5/18
CPC分类号： C07C217/54 , C07C217/30 , C07C217/32 , C07C217/34 , C07C229/34 , C07C2602/08
摘要： Novel calcilytic compounds and methods of using them are provided.
摘要翻译： 提供新的钙质化合物及其使用方法。
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公开(公告)号：US20090247642A1
公开(公告)日：2009-10-01
申请号：US12158950
申请日：2006-12-22
IPC分类号： A61K31/138 , C07C217/64 , C07C213/00
CPC分类号： C07C213/02 , C07C213/08 , C07C213/10 , C07C217/32
摘要： The invention relates to an improved process for preparing metoprolol and its salts.
摘要翻译： 本发明涉及一种制备美托洛尔及其盐的改进方法。
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