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112 条记录 (耗时 0.033 秒)

    Use of Amphiphilic Copolymers as Solubilising Agents
    34.
    发明申请
    Use of Amphiphilic Copolymers as Solubilising Agents 审中-公开
    使用两亲共聚物作为增溶剂

    公开(公告)号：US20080153925A1

    公开(公告)日：2008-06-26

    申请号：US11660403

    申请日：2005-08-03

    申请人： Marianna Pierobon ,  Nathalie Bouillo ,  Ronald Frans Maria Lange ,  Kathrin Meyer ,  Karl Kolter

    发明人： Marianna Pierobon ,  Nathalie Bouillo ,  Ronald Frans Maria Lange ,  Kathrin Meyer ,  Karl Kolter

    IPC分类号： A61K47/32 ,  C08F226/06 ,  C08F220/54 ,  C08F226/02

    CPC分类号： C08F226/06 ,  A61K9/146 ,  A61K47/34

    摘要： Solubilizers prepared by polymerizing: (i) at least one first monomer of the general formula (I): wherein R1 and R2 each independently represent H or CH3, R3 represents a C6-C10-aryl or C7-C12-aralkyl which may be unsubstituted or substituted with one or more C1-C9-alkyl and/or C1-C5-alkoxy substituents, and n represents an integer from 0 to 100; and (ii) at least one second monomer selected from the group consisting of N-vinylamides, N-vinyllactams, N-vinylimines, N-vinylamines having 2 to 15 carbon atoms, and mixtures thereof; and methods of solubilizing active ingredients by combining them with such a solubilizer.

    摘要翻译： 通过聚合制备的增溶剂：（i）至少一种通式（I）的第一单体：其中R 1和R 2各自独立地表示H或CH 3，R 3表示C 6 - 可以是未取代的或被一个或多个C 1 -C 6烷基取代的C 1 -C 10 - 芳基或C 7 -C 12 - 1个-C 9 - 烷基和/或C 1 -C 5 - 烷氧基取代基，n表示0的整数 到100; 和（ii）选自N-乙烯基酰胺，N-乙烯基内酰胺，N-乙烯基亚胺，具有2至15个碳原子的N-乙烯胺的至少一种第二单体及其混合物; 以及通过将活性成分与这种增溶剂组合来增溶活性成分的方法。

    Water-soluble or water-dispersible (co) polymers of hydroxyalkyl (meth) acrylates, a process for their preparation, and their use as coating agent, binder and/or film-forming excipient pharmaceutical dosage forms
    36.
    发明授权
    Water-soluble or water-dispersible (co) polymers of hydroxyalkyl (meth) acrylates, a process for their preparation, and their use as coating agent, binder and/or film-forming excipient pharmaceutical dosage forms 失效
    （甲基）丙烯酸羟烷基酯的水溶性或水分散性（共）聚合物，其制备方法及其作为包衣剂，粘合剂和/或成膜赋形剂药物剂型的用途

    公开(公告)号：US07049360B2

    公开(公告)日：2006-05-23

    申请号：US09964796

    申请日：2001-09-28

    申请人： Maximilian Angel ,  Axel Sanner ,  Karl Kolter

    发明人： Maximilian Angel ,  Axel Sanner ,  Karl Kolter

    IPC分类号： C08K3/20

    CPC分类号： A61K9/2846 ,  A61K9/2027 ,  C08F261/04

    摘要： The present invention relates to water-soluble or water-dispersible copolymers obtainable by free-radical polymerization of a) 80 to 20% by weight of hydroxy-C1–C6-alkyl (meth)acrylate and, where appropriate, one or more compounds of the formula (A) or (B) with R1=H, C1–C6-alkyl, R2=H, CH3 R3=C1–C24-alkyl or mixtures thereof in the presence of b) 20 to 80% by weight of polyvinyl alcohol (PVA) and c) where appropriate 0 to 20% by weight of other polymerizable compounds (C), a process for their preparation, and their use as coating agent, binder and/or film-forming excipient in pharmaceutical dosage forms.

    摘要翻译： 本发明涉及通过自由基聚合得到的水溶性或水分散性共聚物，该共聚物是a）80-20％（重量）的羟基-C 1 -C 6 - - （甲基）丙烯酸烷基酯和（如果合适的话）一种或多种式（A）或（B）的化合物，其中R 1 = H，C 1 -C C 1 -C 6烷基，R 2 = H，CH 3 3 R 3 = C 1〜 -C 24 - - - 烷基或其混合物，b）20-80％（重量）的聚乙烯醇（PVA）和c）适当时0-20％重量的其它可聚合化合物（C ），其制备方法，以及它们作为药物剂型中的包衣剂，粘合剂和/或成膜赋形剂的用途。

    Rapidly soluble film covering based on polyvinylalcohol-polyether graft copolymers combined with components containing hydroxyl, amide, or ester functions
    37.
    发明申请
    Rapidly soluble film covering based on polyvinylalcohol-polyether graft copolymers combined with components containing hydroxyl, amide, or ester functions 审中-公开
    基于聚乙烯醇 - 聚醚接枝共聚物与含有羟基，酰胺或酯官能团的组分组合的快速溶解膜覆盖

    公开(公告)号：US20050107498A1

    公开(公告)日：2005-05-19

    申请号：US10501773

    申请日：2003-02-04

    申请人： Karl Kolter ,  Maximilian Angel

    发明人： Karl Kolter ,  Maximilian Angel

    IPC分类号： A61K9/28 ,  C08K5/15 ,  C08K3/00 ,  C08K3/34

    CPC分类号： A61K9/2853

    摘要： A quick dissolving film coating composition for coating solid substrates is composed of a) 10-90% by weight of a polyvinyl alcohol-polyether graft copolymer (component A), b) 5-80% by weight of at least one further component containing at least one functional group selected from the group consisting of hydroxyl, amide and ester functions (component B), and c) 0-70% by weight of further customary coating constituents (components C).

    摘要翻译： 用于涂布固体基材的快速溶解膜涂料组合物由a）10-90重量％的聚乙烯醇 - 聚醚接枝共聚物（组分A）组成，b）5-80重量％的至少一种另外的组分，其含有 至少一个选自羟基，酰胺和酯官能团的官能团（组分B），和c）0-70重量％的进一步常规涂料组分（组分C）。