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公开(公告)号：US5919785A
公开(公告)日：1999-07-06
申请号：US823921
申请日：1997-03-25
IPC分类号： C07D233/54 , C07D401/06 , C07D403/06 , A61K31/415 , A61K31/495 , C07D241/08
CPC分类号： C07D401/06 , C07D403/06
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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32.发明授权N-heterocyclic piperazinyl and H-heterocyclic piperazinonyl inhibitors of farnesyl-protein transferase 失效法呢基蛋白转移酶的N-杂环哌嗪基和N-杂环哌嗪基酮抑制剂
公开(公告)号：US5859015A
公开(公告)日：1999-01-12
申请号：US826292
申请日：1997-03-27
IPC分类号： A61K31/00 , A61K31/495 , A61K31/496 , A61P9/00 , A61P13/00 , A61P13/12 , A61P27/00 , A61P27/02 , A61P31/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07D401/04 , C07D403/04 , C07D403/12
CPC分类号： C07D403/04 , A61K31/496 , C07D401/04
摘要： The present invention is directed to compounds of the formula A which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras: ##STR1## The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
摘要翻译： 本发明涉及抑制法呢基蛋白转移酶（FTase）和癌基因蛋白Ras的法呢基化的式A化合物：本发明还涉及含有本发明化合物的化学治疗组合物和 抑制法尼基蛋白转移酶和癌基因蛋白Ras的法呢基化。
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公开(公告)号：US5175284A
公开(公告)日：1992-12-29
申请号：US777814
申请日：1991-10-15
IPC分类号： C07D495/18
CPC分类号： C07D495/18
摘要： Intermediates are described for preparing conformationally constrained tricyclic thienothiopyran compounds that are topically effective carbonic anhydrase inhibitors useful in the treatment of ocular hypertension and glaucoma associated therewith.
摘要翻译： 描述了用于制备可用于治疗与其相关的高眼压症和青光眼的局部有效的碳酸酐酶抑制剂的构象受限的三环噻吩并噻喃化合物的中间体。
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34.发明授权4-alkylamino-6-(C.sub.3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides 失效4-氨基亚氨基-6-（C3-5-烃基）噻吩（2,3-B）噻吩-2-磺酰胺-7,7-二氧化物
公开(公告)号：US5091409A
公开(公告)日：1992-02-25
申请号：US524523
申请日：1990-05-17
IPC分类号： A61K31/38 , A61P9/12 , A61P27/02 , C07D495/04 , C07D495/20
CPC分类号： C07D495/04
摘要： 4-Alkylamino-6-(C.sub.3-5 -hydrocarbyl)thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxides wherein the 4-alkylamino group is an ethylamino or propylamino are powerful carbonic anhydrase inhibitors useful in the treatment of ocular hypertension and glaucoma associated therewith.These compounds have the formula ##STR1##
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公开(公告)号：US20100168097A1
公开(公告)日：2010-07-01
申请号：US11922672
申请日：2006-06-23
IPC分类号： A61K31/5377 , C07D403/04 , A61K31/4178 , C07D413/14 , C07D417/14 , A61K31/4245 , A61K31/4439 , A61P31/18
CPC分类号： C07D413/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： Compounds of Formula I: Formula (I); are HIV reverse transcriptase inhibitors, wherein R1, R2, R3, R4 and R5 are defined herein. The compounds of Formula (I) and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译： 式I化合物：式（I）; 是HIV逆转录酶抑制剂，其中R 1，R 2，R 3，R 4和R 5在本文中定义。 式（I）化合物及其药学上可接受的盐可用于抑制HIV逆转录酶，预防和治疗艾滋病毒感染以及预防，延迟发作和治疗艾滋病。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。
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公开(公告)号：US20100113419A1
公开(公告)日：2010-05-06
申请号：US12684478
申请日：2010-01-08
IPC分类号： A61K31/55 , C07D401/14 , A61P25/00
CPC分类号： C07D491/20 , C07D471/10 , C07D471/20 , C07D491/10
摘要： The present invention is directed to compounds of Formula I:Formula I: Formula II: (where variables R1, R2, R3, R4, A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：式I：式II :(其中变量R1，R2，R3，R4，A，B，J，Q，T，V，W，X和Y如本文所定义） 可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20090131494A1
公开(公告)日：2009-05-21
申请号：US11990060
申请日：2006-08-07
申请人： Theresa M. Williams , Xu-Fang Zhang
发明人： Theresa M. Williams , Xu-Fang Zhang
IPC分类号： A61K31/4178 , A61K31/404 , C07D403/12 , A61P31/18 , C07D209/42
CPC分类号： C07D209/42 , C07D403/12
摘要： Certain 1H-indole-2-carboxylates and -2-carboxamides are HIV reverse transcriptase inhibitors. These indole compounds and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译： 某些1H-吲哚-2-羧酸盐和-2-甲酰胺是HIV逆转录酶抑制剂。 这些吲哚化合物及其药学上可接受的盐可用于HIV逆转录酶的抑制，艾滋病毒感染的预防和治疗以及AIDS的预防，延迟发作和治疗。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。
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公开(公告)号：US07476665B2
公开(公告)日：2009-01-13
申请号：US10562297
申请日：2004-06-24
IPC分类号： A61P25/06 , A61K31/55 , C07D401/14
CPC分类号： C07D401/14 , C07D471/04 , C07D487/04
摘要： The present invention is directed to compounds of Formula I: I (where variables R1?, R2?, R3?, R6?, R7?, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：其中变量R
1 ?, R
2 ?, R
3？，R
6？R
7β，G，J，Q，T，U，V，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂， 可用于治疗或预防涉及CGRP的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20080125413A1
公开(公告)日：2008-05-29
申请号：US11795678
申请日：2006-01-13
IPC分类号： A61K31/5513 , C07D243/14 , A61P43/00
CPC分类号： C07D401/14
摘要： Compounds of Formula I: (where variables R1, R2, R3, R7, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache, and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量R1，R2，R3，R7，G，J，Q，T，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛，以及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗CGRP所涉及的疾病中的用途。
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公开(公告)号：US07205292B2
公开(公告)日：2007-04-17
申请号：US10551830
申请日：2004-04-09
IPC分类号： C07D405/14 , A61K31/4545 , A61P25/06
CPC分类号： C07D401/14 , C07D413/14
摘要： The present invention is directed to compounds of Formula I and Formula II: (where variables R1, R2, R3, R4, R6, A, B, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I和式II化合物（其中变量R1，R2，R3，R4，R6，A，B，G，J，W，X和Y如本文所定义）可用作CGRP的拮抗剂 受体，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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