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公开(公告)号：US20100113419A1
公开(公告)日：2010-05-06
申请号：US12684478
申请日：2010-01-08
IPC分类号： A61K31/55 , C07D401/14 , A61P25/00
CPC分类号： C07D491/20 , C07D471/10 , C07D471/20 , C07D491/10
摘要： The present invention is directed to compounds of Formula I:Formula I: Formula II: (where variables R1, R2, R3, R4, A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：式I：式II :(其中变量R1，R2，R3，R4，A，B，J，Q，T，V，W，X和Y如本文所定义） 可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07659264B2
公开(公告)日：2010-02-09
申请号：US11664905
申请日：2005-10-05
IPC分类号： C07D403/12 , C07D403/14 , A61K31/55
CPC分类号： C07D491/20 , C07D471/10 , C07D471/20 , C07D491/10
摘要： The present invention is directed to compounds of Formula I: Formula I: I and Formula II: (where variables R1, R2, R3, R4, A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：式I：I和式II（其中变量R1，R2，R3，R4，A，B，J，Q，T，V，W，X和Y如上所定义 可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07476665B2
公开(公告)日：2009-01-13
申请号：US10562297
申请日：2004-06-24
IPC分类号： A61P25/06 , A61K31/55 , C07D401/14
CPC分类号： C07D401/14 , C07D471/04 , C07D487/04
摘要： The present invention is directed to compounds of Formula I: I (where variables R1?, R2?, R3?, R6?, R7?, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：其中变量R
1 ?, R
2 ?, R
3？，R
6？R
7β，G，J，Q，T，U，V，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂， 可用于治疗或预防涉及CGRP的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20080125413A1
公开(公告)日：2008-05-29
申请号：US11795678
申请日：2006-01-13
IPC分类号： A61K31/5513 , C07D243/14 , A61P43/00
CPC分类号： C07D401/14
摘要： Compounds of Formula I: (where variables R1, R2, R3, R7, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache, and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量R1，R2，R3，R7，G，J，Q，T，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛，以及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗CGRP所涉及的疾病中的用途。
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公开(公告)号：US07205292B2
公开(公告)日：2007-04-17
申请号：US10551830
申请日：2004-04-09
IPC分类号： C07D405/14 , A61K31/4545 , A61P25/06
CPC分类号： C07D401/14 , C07D413/14
摘要： The present invention is directed to compounds of Formula I and Formula II: (where variables R1, R2, R3, R4, R6, A, B, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I和式II化合物（其中变量R1，R2，R3，R4，R6，A，B，G，J，W，X和Y如本文所定义）可用作CGRP的拮抗剂 受体，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07632832B2
公开(公告)日：2009-12-15
申请号：US11795678
申请日：2006-01-13
IPC分类号： C07D401/14 , A61K31/4745 , A61P25/06
CPC分类号： C07D401/14
摘要： Compounds of Formula I: (where variables R1, R2, R3, R7, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache, and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量R1，R2，R3，R7，G，J，Q，T，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛，以及包含这些化合物的药物组合物，以及这些化合物和组合物在预防或治疗CGRP所涉及的疾病中的用途。
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公开(公告)号：US07390798B2
公开(公告)日：2008-06-24
申请号：US11660798
申请日：2005-02-09
IPC分类号： C07D401/14 , C07D471/10 , A61K31/553 , A61K31/55 , A61K31/438 , A61K31/4166 , A61P25/06
CPC分类号： C07D471/04 , C07D401/12 , C07D413/12 , C07D519/00
摘要： The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved
摘要翻译： 本发明涉及式I的化合物：I（其中变量A 1，A 2，B，J，K，m，n，R 4 R 5c，R 5b和R 5c如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗 或预防CGRP所涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途
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公开(公告)号：US07196079B2
公开(公告)日：2007-03-27
申请号：US10562298
申请日：2004-06-24
IPC分类号： C07D401/14 , A61K31/55 , A61P25/06
CPC分类号： C07D401/14
摘要： The present invention is directed to compounds of Formula I: (where variables R1, R2, R3, R6, R7, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：
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公开(公告)号：US07745427B2
公开(公告)日：2010-06-29
申请号：US11665943
申请日：2005-10-18
IPC分类号： C07D471/04 , C07D471/20 , A61K31/55 , A61P25/06
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds of Formula (I) and Formula (II) (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式（I）和式（II）的化合物（其中变量R1，R2，R3，R4，A，B，G，J，Q，T，U，V，W，X和Y为 如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07491713B2
公开(公告)日：2009-02-17
申请号：US10587121
申请日：2005-01-25
申请人： Christopher S. Burgey , Daniel V. Paone , Anthony W Shaw , Craig A. Stump , Theresa M. Williams
发明人： Christopher S. Burgey , Daniel V. Paone , Anthony W Shaw , Craig A. Stump , Theresa M. Williams
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , A61K31/4178 , A61K31/4439 , A61K31/551 , A61K31/553 , A61K31/554 , A61P25/06
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, D, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, pharmaceutical compositions comprising these compounds, use of these compounds and compositions to prevent or treat diseases involving CGRP.
摘要翻译： 式I：和式II化合物（其中变量R1，R2，R3，R4，A，B，D，G，J，Q，T，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂 并且可用于治疗或预防涉及CGRP的疾病，包含这些化合物的药物组合物，这些化合物和组合物的用途，以预防或治疗涉及CGRP的疾病。
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