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公开(公告)号：US20100113419A1
公开(公告)日：2010-05-06
申请号：US12684478
申请日：2010-01-08
IPC分类号： A61K31/55 , C07D401/14 , A61P25/00
CPC分类号： C07D491/20 , C07D471/10 , C07D471/20 , C07D491/10
摘要： The present invention is directed to compounds of Formula I:Formula I: Formula II: (where variables R1, R2, R3, R4, A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：式I：式II :(其中变量R1，R2，R3，R4，A，B，J，Q，T，V，W，X和Y如本文所定义） 可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20070287697A1
公开(公告)日：2007-12-13
申请号：US11665520
申请日：2005-10-12
申请人： Daniel Paone , Anthony Shaw , Craig Potteiger
发明人： Daniel Paone , Anthony Shaw , Craig Potteiger
IPC分类号： A61K31/55 , A61K31/44 , A61K31/445 , A61K31/551 , A61P43/00 , C07D213/00 , C07D237/26 , C07D241/36 , C07D267/02 , C07D243/06 , C07D239/70 , C07D223/02 , C07D211/00 , A61K31/553 , A61K31/4985 , A61K31/519
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Compounds of Formula (I) and Formula (II) (where variables R1, R2, R4, A, B, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式（I）和式（II）化合物（其中R 1，R 2，R 4，A，B，W， X，Y和Z如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20080070899A1
公开(公告)日：2008-03-20
申请号：US11664905
申请日：2005-10-05
IPC分类号： C07D401/14 , A61K31/55 , A61P25/06
CPC分类号： C07D491/20 , C07D471/10 , C07D471/20 , C07D491/10
摘要： The present invention is directed to compounds of Formula I: Formula I: I and Formula II: (where variables R1, R2, R3, R4, A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I的化合物：式I：I和式II：（其中R 1，R 2，R 3， >，R 4，A，B，J，Q，T，V，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07659264B2
公开(公告)日：2010-02-09
申请号：US11664905
申请日：2005-10-05
IPC分类号： C07D403/12 , C07D403/14 , A61K31/55
CPC分类号： C07D491/20 , C07D471/10 , C07D471/20 , C07D491/10
摘要： The present invention is directed to compounds of Formula I: Formula I: I and Formula II: (where variables R1, R2, R3, R4, A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：式I：I和式II（其中变量R1，R2，R3，R4，A，B，J，Q，T，V，W，X和Y如上所定义 可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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