公开(公告)号：US11890353B2

公开(公告)日：2024-02-06

申请号：US17071653

申请日：2020-10-15

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Evan A. Scott ,  Guillermo A. Ameer ,  Jacqueline A. Burke ,  Helena Freire Haddad

IPC: A61K49/00 ,  A01K67/027

CPC classification number: A61K49/0008 ,  A01K67/027 ,  A01K2207/10 ,  A01K2227/105 ,  A01K2267/03

Abstract: The present invention provides methods of making an in vivo animal model for detecting anti-poly(ethylene glycol) (PEG) antibodies. The methods of the disclosure comprises administering subcutaneously to an animal model a composition comprising antibodies against poly(ethylene glycol) chains with a molecular weight of at least 550 Da to maintain an anti-PEG antibody level within the animal model. The in vivo animal model can be used for testing and screening drugs and other compositions for adverse reactions, bioavailability, and immunogenicity prior to administration to a human subject.

公开(公告)号：US20220305176A1

公开(公告)日：2022-09-29

申请号：US17638905

申请日：2020-08-31

Applicant: Northwestern University ,  Ann and Robert H. Lurie Children's Hospital of Chicago

Inventor： Guillermo A. Ameer ,  Arun K. Sharma ,  Xinlong Wang ,  Matthew I. Bury

IPC: A61L27/38 ,  A61L27/18

Abstract: Provided herein are materials and methods related to scaffolds and uses thereof. In some embodiments, provided herein are poly (octamethylene-octanol citrates) (POOC) scaffolds with native mechanical properties that are comparable to urinary bladder tissue. In some embodiments, provided herein are methods for the synthesis of POOC scaffolds with native mechanical properties that are comparable to urinary bladder tissue by including octanol in the polycondensation synthesis of POC. In some embodiments, provided herein are methods of use of the disclosed scaffolds, including for urinary bladder tissue regeneration.

公开(公告)号：US20220195072A1

公开(公告)日：2022-06-23

申请号：US17548204

申请日：2021-12-10

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Yunxiao Zhu

IPC: C07K19/00 ,  A61K47/61 ,  A61K47/62 ,  A61P7/02 ,  A61K9/08 ,  C07K7/06 ,  C07K14/745 ,  C08B37/00 ,  G01N33/86

Abstract: Provided herein is technology relating to anticoagulant therapies and particularly, but not exclusively, to anticoagulant compositions for localized and targeted administration and related methods and kits for treatment of a subject with a localized and targeted anticoagulant therapy.

公开(公告)号：US20220133958A1

公开(公告)日：2022-05-05

申请号：US17310290

申请日：2020-01-29

Applicant: Northwestern University

Inventor： Banu Akar ,  Henry Oliver T. Ware ,  Cheng Sun ,  Guillermo A. Ameer

IPC: A61L31/04 ,  C09D167/04 ,  B29C64/124 ,  A61L27/26 ,  B33Y70/00 ,  B33Y10/00 ,  B29L31/00 ,  B33Y80/00

Abstract: Provided herein photo-reactive inks, thermal-curable materials and objects (e.g., medical implants, scaffolds, devices, etc.) made therefrom, and methods of preparation and use thereof.

公开(公告)号：US20210299158A1

公开(公告)日：2021-09-30

申请号：US16755494

申请日：2018-10-11

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Jason A. Wertheim ,  Bin Jiang

IPC: A61K31/727 ,  A61K38/08 ,  A61K47/54 ,  A61K47/64

Abstract: Disclosed are heparin conjugates comprising heparin conjugated to a peptide that binds to a protein of the extracellular matrix (ECM) of cellular tissue, such as a collagen-binding peptide that binds to collagen of the ECM. The disclosed heparin conjugates may be utilized in methods that include treating ECM material to incorporate the heparin conjugates and impart anticoagulant activity to the ECM. The disclosed heparin conjugates also may be formulated as pharmaceutical compositions for treating and/or preventing vascular injuries and conditions.

公开(公告)号：US10561761B2

公开(公告)日：2020-02-18

申请号：US15537054

申请日：2015-12-18

Applicant: Northwestern University

Inventor： Jisheng Xiao ,  Guillermo A. Ameer

IPC: A61L15/26 ,  A61K31/555 ,  A61L15/44 ,  A61P17/02 ,  A61K47/34 ,  A61L15/20 ,  A61L15/42

Abstract: Provided herein are polymer and metal organic frameworks (MOFs) composites, and methods of use and preparation thereof. In particular, Poly(polyethyleneglycol citrate-co-N-isopropylacrylamide) (PPCN) and copper MOF composites are provided.