公开(公告)号：US12214104B2

公开(公告)日：2025-02-04

申请号：US16646848

申请日：2018-09-13

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Henry Oliver Tenadooah Ware ,  Cheng Sun ,  Congwen Duan

IPC: A61L27/16 ,  A61L27/04 ,  A61L27/10 ,  A61L27/12 ,  A61L27/58 ,  B29C35/02 ,  B29C64/124 ,  B29C64/30 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y70/10 ,  B33Y80/00

Abstract: Provided herein photo-reactive inks, thermal-curable materials and objects (e.g., medical implants, scaffolds, devices, etc.) made therefrom, and methods of preparation and use thereof.

公开(公告)号：US12036234B2

公开(公告)日：2024-07-16

申请号：US16755494

申请日：2018-10-11

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Jason A. Wertheim ,  Bin Jiang ,  Kyle Koss

IPC: A61K31/727 ,  A61K38/08 ,  A61K47/54 ,  A61K47/64

CPC classification number: A61K31/727 ,  A61K38/08 ,  A61K47/547 ,  A61K47/6425

Abstract: Disclosed are heparin conjugates comprising heparin conjugated to a peptide that binds to a protein of the extracellular matrix (ECM) of cellular tissue, such as a collagen-binding peptide that binds to collagen of the ECM. The disclosed heparin conjugates may be utilized in methods that include treating ECM material to incorporate the heparin conjugates and impart anticoagulant activity to the ECM. The disclosed heparin conjugates also may be formulated as pharmaceutical compositions for treating and/or preventing vascular injuries and conditions.

公开(公告)号：US11565026B2

公开(公告)日：2023-01-31

申请号：US17308825

申请日：2021-05-05

Applicant: Northwestern University

Inventor： Jian Yang ,  Evan C. Baker ,  Henry O. T. Ware ,  Fan Zhou ,  Cheng Sun ,  Guillermo A. Ameer ,  Robert Van Lith

IPC: A61L31/06 ,  C08J3/24 ,  B33Y80/00 ,  B29C64/135 ,  B29C41/22 ,  B29C41/00 ,  B33Y30/00 ,  B33Y70/00 ,  B29C64/20 ,  A61L31/16 ,  A61L31/18 ,  C09D167/06 ,  B29L31/00 ,  B33Y10/00 ,  B29K33/00 ,  B29K105/00

Abstract: Provided herein are methods, compositions, devices, and systems for the 3D printing of biomedical implants. In particular, methods and systems are provided for 3D printing of biomedical devices (e.g., endovascular stents) using photo-curable biomaterial inks (e.g., or methacrylated poly(diol citrate)).

公开(公告)号：US20210346576A1

公开(公告)日：2021-11-11

申请号：US17308825

申请日：2021-05-05

Applicant: Northwestern University

Inventor： Jian Yang ,  Evan C. Baker ,  Henry O. T. Ware ,  Fan Zhou ,  Cheng Sun ,  Guillermo A. Ameer ,  Robert Van Lith

IPC: A61L31/06 ,  C08J3/24 ,  B33Y80/00 ,  B29C64/135 ,  B29C41/22 ,  B29C41/00 ,  B33Y30/00 ,  B33Y70/00 ,  B29C64/20 ,  A61L31/16 ,  A61L31/18 ,  C09D167/06

Abstract: Provided herein are methods, compositions, devices, and systems for the 3D printing of biomedical implants. In particular, methods and systems are provided for 3D printing of biomedical devices (e.g., endovascular stents) using photo-curable biomaterial inks (e.g., or methacrylated poly(diol citrate)).

公开(公告)号：US20190336648A1

公开(公告)日：2019-11-07

申请号：US16468224

申请日：2017-12-08

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Simona Morochnik

IPC: A61L27/52 ,  A61L27/54 ,  A61K31/661 ,  A61K38/06 ,  A61K33/06 ,  A61K9/06 ,  A61K9/00

Abstract: Provided herein are injectable, thermoresponsive hydrogels that are liquid at room temperature, provide a carrier material, and gel at body temperature to allow for controlled release. In particular, PPCN-based hydrogels are provided with therapeutic agents (e.g., drugs, ions, etc.) incorporated within or appended thereto, and methods of preparation and use thereof, for example, for the promotion of bone formation/repair and/or the treatment of bone diseases.

公开(公告)号：US10406385B2

公开(公告)日：2019-09-10

申请号：US15536858

申请日：2015-12-18

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Robert van Lith ,  Jian Yang

IPC: A61K8/49 ,  A61K8/85 ,  A61L27/50 ,  A61Q17/04 ,  C08G69/44 ,  A61K31/787 ,  A61K31/5365 ,  G02B1/04 ,  C08G69/40

Abstract: Provided herein are compositions comprising panthenol-citrate containing materials. In particular, panthenol citrate compounds, oligomers, and polymers, and methods of use and synthesis thereof, are provided herein. Panthenol-citrate containing materials are a class of nontoxic, photoluminescent-chromophore-containing compounds, oligomers, and polymers with high absorption in the UVA and UVB range that can be incorporated and/or engineered into a variety of optically-active biomaterials (e.g., sunscreen products).

公开(公告)号：US11850328B2

公开(公告)日：2023-12-26

申请号：US16349186

申请日：2017-11-14

Applicant: Northwestern University

Inventor： Guillermo A. Ameer

IPC: A61L27/46 ,  A61K9/00 ,  A61K9/08 ,  A61K47/32 ,  A61L27/18 ,  A61L27/50 ,  C08G63/47 ,  C08G63/91 ,  C08L67/00 ,  C08L101/00 ,  A61L27/16 ,  C08L101/16

CPC classification number: A61L27/46 ,  A61K9/00 ,  A61K9/0024 ,  A61K47/32 ,  A61L27/16 ,  A61L27/18 ,  A61L27/50 ,  C08G63/47 ,  C08G63/914 ,  C08L67/00 ,  C08L101/00 ,  C08L101/16 ,  A61L2300/802 ,  A61L2430/02 ,  A61L27/18 ,  C08L67/00 ,  A61L27/46 ,  C08L67/00

Abstract: Provided herein are thermoresponsive polymer materials and methods of preparation and use thereof. In particular, materials are provided that cure upon exposure to physiologic conditions (e.g., human body temperature) and find use in, for example, orthopedic surgery, bone tissue engineering, and the repair of bone injuries and defects.

公开(公告)号：US20230263729A1

公开(公告)日：2023-08-24

申请号：US18177694

申请日：2023-03-02

Applicant: Northwestern University

Inventor： Evan A. Scott ,  Guillermo A. Ameer ,  Jacqueline A. Burke ,  Sean D. Allen ,  Sijia Yi

IPC: A61K9/127 ,  A61K31/593 ,  A61K31/436 ,  A61K31/192 ,  A61P41/00 ,  A61K47/60 ,  A61K47/64 ,  A61K47/54 ,  A61P9/10

CPC classification number: A61K9/1273 ,  A61K31/593 ,  A61K31/436 ,  A61K31/192 ,  A61P41/00 ,  A61K47/60 ,  A61K47/64 ,  A61K47/543 ,  A61P9/10 ,  A61K9/0019

Abstract: Provided herein are nanocarriers for delivery of immunosuppressive agents. In some embodiments, provided herein are nanocarriers comprising a core comprising a poly(ethylene glycol)-block-poly(propylene sulfide) copolymer and least one therapeutic agent. In some embodiments, the nanocarriers may further comprise a targeting ligand displayed on a surface of the nanocarrier. The at least one therapeutic agent may be an anti-inflammatory agent. The disclosed nanocarriers may be incorporated into pharmaceutical compositions for use in methods of treating an inflammatory condition or preventing transplantation rejection in a subject.

公开(公告)号：US20220119510A1

公开(公告)日：2022-04-21

申请号：US17503057

申请日：2021-10-15

Applicant: Northwestern University

Inventor： Evan A. Scott ,  Guillermo A. Ameer ,  Helena Freire Haddad ,  Jacqueline A. Burke

IPC: C07K16/18 ,  A61K47/60 ,  A61K47/02

Abstract: The present invention provides methods for generating a mouse model that produces anti-polyethylene glycol (PEG) antibodies. Also provided are mice generated by said methods and methods of using these mice to screen PEG-containing products in vivo.

公开(公告)号：US20180201899A1

公开(公告)日：2018-07-19

申请号：US15744216

申请日：2016-07-15

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Bin Jiang ,  Michele Jen ,  Jason A. Wertheim

IPC: C12N5/071 ,  A61K35/44 ,  A61K38/50 ,  C12N9/80 ,  G01N33/50

CPC classification number: C12N5/069 ,  A01N1/0226 ,  A61K35/44 ,  A61K38/50 ,  C12N5/0696 ,  C12N9/1077 ,  C12N9/80 ,  C12N15/00 ,  C12N2501/72 ,  C12N2506/45 ,  C12N2510/00 ,  C12N2740/16043 ,  C12Y204/0203 ,  G01N33/5014 ,  G01N33/502

Abstract: Compositions comprising endothelial cells (ECs) differentiated from induced pluripotent stem cells (iPSC)that over-express Sirtuin 1 (SIRT1) are disclosed. Further disclosed are methods of preparation of the compositions, and methods for treating a subject comprising administering transplatanbe cells, tissue, or organ comprising the iPSC-derived ECs overexpressing SIRT1, as well as methods of testing an agent for therapeutic efficacy and toxicity using the compositions.