利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

55 条记录 (耗时 0.028 秒)

    Antagonists of immunosuppressive macrolides
    31.
    发明授权
    Antagonists of immunosuppressive macrolides 失效
    免疫抑制大环内酯拮抗剂

    公开(公告)号：US5190950A

    公开(公告)日：1993-03-02

    申请号：US766908

    申请日：1991-09-26

    申请人： Thomas R. Beattie ,  Matthew J. Wyvratt ,  Francis J. Dumont

    发明人： Thomas R. Beattie ,  Matthew J. Wyvratt ,  Francis J. Dumont

    IPC分类号： C07H19/01

    CPC分类号： C07H19/01

    摘要： A method for the modification of treatment of an immuno regulatory disorder or disease with an FK-506-type immunosuppressive macrolide comprising the administration to a mammalian species in need of such modification of an effective amount of a compound of the formula I. ##STR1##

    摘要翻译： 一种用FK-506型免疫抑制性大环内酯治疗免疫调节性疾病或疾病的方法，包括向需要这种修饰的哺乳动物物种施用有效量的式I化合物。 一世

    Fluoromacrolides having immunosuppressive activity
    32.
    发明授权
    Fluoromacrolides having immunosuppressive activity 失效
    具有免疫抑制活性的氟康唑

    公开(公告)号：US5189042A

    公开(公告)日：1993-02-23

    申请号：US748583

    申请日：1991-08-22

    申请人： Mark Goulet ,  Thomas R. Beattie ,  Matthew J. Wyvratt

    发明人： Mark Goulet ,  Thomas R. Beattie ,  Matthew J. Wyvratt

    IPC分类号： A61K31/40 ,  A61K31/435 ,  A61P11/00 ,  A61P37/06 ,  C07D498/18 ,  C07H19/01

    CPC分类号： C07H19/01

    摘要： Fluoromacrolides and derivatives of the general structural Formula I: ##STR1## have been prepared from suitable precursors by oxidation and fluorination at C-20. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses. Also, these macrolides are useful in the treatment of reversible obstructive airways disease, particularly asthma. Furthermore, these macrolides are useful as hair revitalizing agents, especially in the treatment of male pattern alopecia or alopecia senilis.

    Hydroxymacrolide derivatives having immunosuppressive activity
    37.
    发明授权
    Hydroxymacrolide derivatives having immunosuppressive activity 失效
    具有免疫抑制活性的羟肟酸衍生物

    公开(公告)号：US5064835A

    公开(公告)日：1991-11-12

    申请号：US486700

    申请日：1990-03-01

    申请人： Richard J. Bochis ,  Huyn O. Ok ,  Matthew J. Wyvratt

    发明人： Richard J. Bochis ,  Huyn O. Ok ,  Matthew J. Wyvratt

    IPC分类号： A61K31/40 ,  A61K31/445 ,  A61P17/00 ,  A61P37/06 ,  C07D498/18 ,  C07H19/01

    CPC分类号： C07H19/01

    摘要： Novel hydroxymacrolide derivatives of the general structural Formula I: ##STR1## have been prepared from (a) suitable precursor(s) by selective reduction of the ketone at C-2. These macrolide immunosuppressants are useful in a human host for the treatment of autoimmune diseases (such as juvenile-onset diabetes melitus, multiple sclerosis and rheumatoid arthritis), infectious diseases and/or the prevention of rejection of foreign organ transplants, e.g. bone marrow and heart transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses such as: psoriasis, atopical dermatitiis, contact dermatitis and further eczematous dermatitises, seborrhoeic dermatitis, Lichen planus, Pemphigus, bullous Pemphigoid, Epidermolysis bullosa, urticaria, angioedemas, vasculitides, erythemas, cutaneous eospinphilias, Lupus erythematosus or Alopecia areata.

    Antiprotozoal imidazopyridine compounds
    39.
    发明授权
    Antiprotozoal imidazopyridine compounds 有权
    抗原虫咪唑并吡啶化合物

    公开(公告)号：US07504501B2

    公开(公告)日：2009-03-17

    申请号：US10548154

    申请日：2004-03-02

    申请人： Matthew J. Wyvratt ,  Tesfaye Biftu ,  Michael H. Fisher ,  Dennis M. Schmatz

    发明人： Matthew J. Wyvratt ,  Tesfaye Biftu ,  Michael H. Fisher ,  Dennis M. Schmatz

    IPC分类号： C07D403/04 ,  A61K31/429

    CPC分类号： C07D471/04 ,  C07D519/00

    摘要： Compounds described by the Formula (I): (I) or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidial agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s).

    摘要翻译： 由式（I）表示的化合物：（I）或其药学上可接受的盐或N-氧化物。 该化合物可用于治疗和预防哺乳动物和鸟类中的原生动物疾病。 控制家禽中球虫病的方法包括单独施用有效量的化合物，或与一种或多种抗球虫剂组合施用。 用于控制家禽中球虫病的组合物包含单独的化合物，或与一种或多种抗球虫剂组合。 用于治疗和预防哺乳动物原生动物疾病的方法，例如弓形虫病，疟疾，非洲锥虫病，恰加斯病和机会性感染包括单独施用化合物，或与一种或多种抗原虫剂组合施用。