利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

29 条记录 (耗时 0.054 秒)

    Aralkyl and aralkenyl glycosides as inhibitors of antigen-specific T-cell proliferation
    7.
    发明授权
    Aralkyl and aralkenyl glycosides as inhibitors of antigen-specific T-cell proliferation 失效
    芳烷基和芳烯基糖苷作为抗原特异性T细胞增殖的抑制剂

    公开(公告)号：US4554349A

    公开(公告)日：1985-11-19

    申请号：US540594

    申请日：1983-10-11

    申请人： Mitree M. Ponpipom ,  Tsung-Ying Shen ,  Robert L. Bugianesi

    发明人： Mitree M. Ponpipom ,  Tsung-Ying Shen ,  Robert L. Bugianesi

    IPC分类号： C07H15/18 ,  C07H5/06

    CPC分类号： C07H15/18

    摘要： The invention disclosed herein relates to novel 1-deoxyglycosides, preferably 1-deoxy-D-mannopyranosides and 1-deoxy-L-rhamnopyranosides, having in the 1-position of the pyranose ring an aralkylthio/aralkenylthio, aralkyloxy/aralkenyloxy or aralkanoylamino/aralkenoylamino substituent; and to novel processes for preparing these 1-substituted-1-deoxyglycosides starting with the corresponding tetra-O-acetylglycopyranosyl bromide or amine. The 6-hydroxy group of 1-substituted-1 deoxyglycopyranosides can also be replaced by other functional groups. These aralkylthio/aralkenylthio, aralkyloxy/aralkenyloxy and aralkanoylamino/aralkenoylamino 1-deoxyglycosides are potent inhibitors of antigen-specific T-cell proliferation and are also useful as inhibitors of delayed-type hypersensitivity reactions.

    摘要翻译： 本文公开的本发明涉及新的1-脱氧糖苷，优选1-脱氧-D-甘露吡喃糖苷和1-脱氧-L-鼠李糖吡喃糖苷，其在吡喃糖环的1-位具有芳烷硫基/芳烯基硫基，芳烷氧基/芳烯基氧基或芳烷酰氨基/芳烯基酰氨基 取代基; 以及由相应的四-O-乙酰基吡喃葡糖基溴或胺开始制备这些1-取代-1-脱氧糖苷的新方法。 1-取代-1脱氧吡喃糖苷的6-羟基也可以被其它官能团取代。 这些芳烷硫基/芳烯基硫基，芳烷氧基/芳烯基氧基和芳烷酰氨基/芳烯酰氨基-1-脱氧糖苷是抗原特异性T细胞增殖的有效抑制剂，也可用作延迟型超敏反应的抑制剂。

    1-Substituted glycopyranosides
    8.
    发明授权
    1-Substituted glycopyranosides 失效
    1-取代的吡喃糖苷

    公开(公告)号：US4228274A

    公开(公告)日：1980-10-14

    申请号：US922897

    申请日：1978-07-10

    申请人： Mitree M. Ponpipom ,  Robert L. Bugianesi ,  Philippe L. Durette ,  Howard M. Katzen ,  Tsung-Ying Shen

    发明人： Mitree M. Ponpipom ,  Robert L. Bugianesi ,  Philippe L. Durette ,  Howard M. Katzen ,  Tsung-Ying Shen

    IPC分类号： C07H13/04 ,  C07H15/04 ,  C07H15/14 ,  C07H5/06 ,  C07H5/08

    CPC分类号： C07H13/04 ,  C07H15/04 ,  C07H15/14

    摘要： The invention disclosed herein relates to novel 1-deoxy-glycopyranosides, preferably 1-deoxy-D-mannopyranosides, having in the 1-position of the pyranoside ring an .omega.-aminoalkylthio, .omega.-aminoalkyloxy or .omega.-aminoalkanoylamino substituent; and to novel processes for preparing these 1-substituted-1-deoxy-glycopyranosides starting with the corresponding tetra-O-acetyl-glycopyranosyl bromide or amine. These .omega.-amino(alkylthio, alkyloxy or alkanoylamino)-1-deoxy-glycopyranosides, and in particular 1-[(6'-aminohexyl)thio or oxy]-1-deoxy-D-mannopyranosides, possess insulin-like activity.

    摘要翻译： 本文公开的本发明涉及在吡喃糖苷环的1位具有ω-氨基烷硫基，ω-氨基烷氧基或ω-氨基烷酰基氨基取代基的1-脱氧-D-甘露吡喃糖苷类的新型1-脱氧-D-吡喃甘露糖苷， 以及由相应的四-O-乙酰基 - 吡喃葡糖基溴或胺开始制备这些1-取代-1-脱氧 - 糖吡喃糖苷的新方法。 这些ω-氨基（烷硫基，烷氧基或烷酰氨基）-1-脱氧 - 糖吡喃糖苷，特别是1 - [（6'-氨基己基）硫代或氧基] -1-脱氧-D-甘露吡喃糖苷类，具有胰岛素样活性。