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公开(公告)号：US06399786B1
公开(公告)日：2002-06-04
申请号：US09901264
申请日：2001-07-09
IPC分类号： A61K31407
CPC分类号： C07D491/16 , A01N43/90 , C07D491/22
摘要： The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.
摘要翻译： 本发明涉及杀螨，抗寄生虫，杀虫剂和驱肠虫剂的新型节肢动物酸衍生物。
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公开(公告)号：US06586452B1
公开(公告)日：2003-07-01
申请号：US09901266
申请日：2001-07-09
申请人： Thomas Shih , Steven L. Colletti , Michael H. Fisher , Peter T. Meinke , Howard C. H. Kuo , Prasun K. Chakravarty , Matthew J. Wyvratt , Sriram Tyagarajan , Richard Berger
发明人： Thomas Shih , Steven L. Colletti , Michael H. Fisher , Peter T. Meinke , Howard C. H. Kuo , Prasun K. Chakravarty , Matthew J. Wyvratt , Sriram Tyagarajan , Richard Berger
IPC分类号： C07D48716
CPC分类号： C07D491/16 , A61K31/407 , C07D491/22
摘要： The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.
摘要翻译： 本发明涉及杀螨，抗寄生虫，杀虫剂和驱肠虫剂的新型节肢动物酸衍生物。
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公开(公告)号：US06197975B1
公开(公告)日：2001-03-06
申请号：US09077565
申请日：1998-06-01
IPC分类号： C07D40312
CPC分类号： C07D401/06 , C07D209/14 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/10
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译： 公开了式（I）化合物及其药学上可接受的盐，其可用作GnRH的拮抗剂，因此可用于治疗男性和女性中各种性激素相关和其他病症。
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4.发明授权
公开(公告)号：US5030640A
公开(公告)日：1991-07-09
申请号：US293785
申请日：1989-01-05
IPC分类号： A23K1/16 , A61K31/41 , A61K31/44 , A61K31/4427 , A61K31/505 , A61P3/04 , A61P11/08 , A61P25/24 , A61P25/26 , C07D401/12 , C07D403/12 , C07D487/04
CPC分类号： C07D401/12 , C07D403/12
摘要： .alpha.-Heterocyclic ethanolamino alkylindole derivatives and compositions made therefrom are potent .beta.-agonists having utility as growth promotion agents for animals, bronchodilators, antidepressants and antiobesity agents.
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公开(公告)号：US5019578A
公开(公告)日：1991-05-28
申请号：US506312
申请日：1990-04-09
IPC分类号： A23K1/16 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/89 , C07D239/42 , C07D471/04
CPC分类号： C07D213/73 , A23K20/116 , C07D213/74 , C07D213/75 , C07D213/89 , C07D239/42 , C07D471/04
摘要： The instant invention concerns certain .alpha.-heterocyclic ethanol amines wherein the amine group is substituted with various alkyl and unsaturated alkyl groups optionally further substituted with hydroxy, or alkoxy groups of the formula: ##STR1## These compounds are useful as growth promotion agents in animals.
摘要翻译： 本发明涉及某些α-杂环乙醇胺，其中胺基被任选进一步被羟基取代的各种烷基和不饱和烷基取代，或下式的烷氧基：这些化合物可用作动物中的生长促进剂。
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公开(公告)号：US5789587A
公开(公告)日：1998-08-04
申请号：US744296
申请日：1996-11-06
IPC分类号： C07D471/04 , C07D487/04 , C07D495/04 , A61K31/55
CPC分类号： C07D471/04 , C07D487/04 , C07D495/04
摘要： There are disclosed certain novel compounds identified as heterocyclic-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such heterocyclic-fused lactams as the active ingredient thereof are also disclosed.
摘要翻译： 公开了鉴定为杂环稠合内酰胺的某些新化合物，其促进人和动物中生长激素的释放。 该物质可用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人体中，增加受缺乏正常分泌天然生长激素影响的人的身高。 还公开了含有这样的杂环稠合内酰胺作为其活性成分的生长促进组合物。
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公开(公告)号：US5780437A
公开(公告)日：1998-07-14
申请号：US760816
申请日：1996-12-05
申请人： Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Narindar N. Girotra , Peter Lin , Matthew J. Wyvratt
发明人： Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Narindar N. Girotra , Peter Lin , Matthew J. Wyvratt
IPC分类号： C07D20060101 , C07D401/12 , C07D401/14 , C07D413/14 , C07D487/08 , A61K38/00 , A61K31/40 , A61K31/54
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D487/08
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译： 公开了式（I）的化合物及其药学上可接受的盐，其可用作GnRH的拮抗剂，因此可用于治疗两种男性中各种性激素相关和其他病症 和妇女。
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公开(公告)号：US5310737A
公开(公告)日：1994-05-10
申请号：US12190
申请日：1993-02-02
IPC分类号： A61K31/55 , A61K31/554 , A61K38/00 , A61P43/00 , C07D223/16 , C07D267/14 , C07D279/16 , C07D281/10 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/10 , C07D453/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07D281/02
CPC分类号： C07D223/16 , C07D267/14 , C07D279/16 , C07D281/10 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/10 , C07D417/10 , C07D453/02 , C07K5/06034 , C07K5/0606 , C07K5/06078 , C07K5/06086 , A61K38/00
摘要： There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed.
摘要翻译： 公开了确定为促进人和动物中生长激素释放的苯并稠合内酰胺的某些新化合物。 该物质可用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人体中，增加受缺乏正常分泌天然生长激素影响的人的身高。 还公开了含有这样的苯并稠合内酰胺作为其活性成分的生长促进组合物。
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公开(公告)号：US5756507A
公开(公告)日：1998-05-26
申请号：US760851
申请日：1996-12-05
申请人： Mark Goulet , Lin Chu , Wallace T. Ashton , Michael H. Fisher , Matthew J. Wyvratt , Roy G. Smith , Robert L. Bugianesi , Mitree M. Ponpipom , Yi Tien Yang , Peter Lin
发明人： Mark Goulet , Lin Chu , Wallace T. Ashton , Michael H. Fisher , Matthew J. Wyvratt , Roy G. Smith , Robert L. Bugianesi , Mitree M. Ponpipom , Yi Tien Yang , Peter Lin
IPC分类号： C07D209/14 , C07D209/16 , A61K31/405 , A61K31/495 , C07D209/10 , C07D403/06
CPC分类号： C07D209/14 , C07D209/16
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US5606054A
公开(公告)日：1997-02-25
申请号：US166440
申请日：1993-12-14
IPC分类号： C07D471/04 , C07D487/04 , C07D495/04 , A61K31/55
CPC分类号： C07D471/04 , C07D487/04 , C07D495/04
摘要： There are disclosed certain novel compounds identified as heterocyclic-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such heterocyclic-fused lactams as the active ingredient thereof are also disclosed.
摘要翻译： 公开了鉴定为杂环稠合内酰胺的某些新化合物，其促进人和动物中生长激素的释放。 该物质可用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人体中，增加受缺乏正常分泌天然生长激素影响的人的身高。 还公开了含有这样的杂环稠合内酰胺作为其活性成分的生长促进组合物。
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