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31.发明授权公开(公告)号：US06530915B1
公开(公告)日：2003-03-11
申请号：US09622427
申请日：2000-10-20
IPC分类号： A61B1820
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2017/00172
摘要： A photothermal structure designed for the uniform application of a photothermal material, such as, for example, a dye or a pigment, to a tissue, e.g., the stratum corneum. In one embodiment, the photothermal structure comprises photothermal material combined with a carrier, such as, for example, an adhesive or an ink, and the resulting combination is applied to a substrate, such as, for example, an inert polymeric substrate to form a photothermal structure. In another embodiment, the photothermal structure comprises photothermal material incorporated into a film-forming polymeric material.
摘要翻译： 设计用于将光热材料（例如染料或颜料）均匀地施加到组织例如角质层上的光热结构。 在一个实施方案中，光热结构包括与载体（例如粘合剂或油墨）组合的光热材料，并且将所得到的组合施加到基底，例如惰性聚合物基底上以形成 光热结构。 在另一个实施方案中，光热结构包括掺入成膜聚合物材料中的光热材料。
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公开(公告)号：US06226541B1
公开(公告)日：2001-05-01
申请号：US08992576
申请日：1997-12-17
IPC分类号： A61B500
CPC分类号： A61B5/0059 , A61B5/0075 , A61B5/1495 , A61B2560/0233 , G01J5/02 , G01J5/021 , G01J5/04 , G01J5/048 , G01J5/522 , G01N21/278
摘要： A disposable calibration device is used to calibrate a measurement system which transmits radiation or acoustic waves to a material or tissue in order to effect measurements. The disposable calibration device includes a structure with a window through which the radiation or acoustic waves can be transmitted, as well as a removable calibration target arranged on the window and capable of returning a portion of the radiation or acoustic waves for calibrating the measurement system. The removable calibration target can be peeled from a window to allow a measurement to be made on the material or tissue. Once a measurement is complete, the disposable calibration device can be discarded and a new calibration device can be inserted on the measuring system.
摘要翻译： 一次性校准装置用于校准将辐射或声波传输到材料或组织以测量的测量系统。 一次性校准装置包括具有透射辐射或声波的窗口的结构以及布置在窗口上并且能够返回一部分辐射或声波以便校准测量系统的可移除校准目标。 可移除的校准目标可以从窗口剥离，以允许在材料或组织上进行测量。 一旦测量完成，可以丢弃一次性校准装置，并且可以在测量系统上插入新的校准装置。
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33.发明授权Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue 失效用于提高微孔生物组织中流体通量的方法和装置公开(公告)号：US06173202B2
公开(公告)日：2001-01-09
申请号：US09036053
申请日：1998-03-06
申请人： Jonathan A. Eppstein
发明人： Jonathan A. Eppstein
IPC分类号： A61N130
CPC分类号： A61K41/0047 , A61B10/0045 , A61B18/20 , A61B2010/008 , A61B2017/00765 , A61M37/0092
摘要： A method and apparatus for enhancing the flux rate of a fluid through a biological membrane. The method includes the steps of porating a section of the tissue to form one or more micropores in the tissue, and applying a flux enhancer to the tissue through the one or more micropores. The resulting enhancement of fluid flux in the tissue enables more effective harvesting from the body of fluids, as well as more effective delivery of a drug.
摘要翻译： 一种用于增强通过生物膜的流体通量率的方法和装置。 该方法包括以下步骤：将组织的一部分铺上以在组织中形成一个或多个微孔，以及通过一个或多个微孔将通量增强剂施加到组织。 由此导致的组织中的流体通量的增强使得能够更有效地从体液中收获，以及更有效地递送药物。
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34.发明授权Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications 失效用于电穿孔微孔组织的装置和方法，用于提高监测和递送应用的通量
公开(公告)号：US6022316A
公开(公告)日：2000-02-08
申请号：US36169
申请日：1998-03-06
CPC分类号： A61N1/0416 , A61N1/30 , A61N1/325 , A61N1/327 , A61N1/0476
摘要： An apparatus and a method for electroporating tissue. At least one micropore is formed to a predetermined depth through a surface of the tissue, and electrical voltage is applied between an electrode electrically coupled to the micropore and another electrode spaced therefrom. By applying electroporation to tissue that has been breached by a micropore, the electroporation effects can be targeted at tissue structures beneath the surface, such as capillaries, to greatly enhance the withdrawal of biological fluid, and the delivery for uptake of compounds into the tissue. In a preferred embodiment, a device is provided having elements that are suitable for microporating the tissue and which serve as the electroporation electrodes.
摘要翻译： 一种用于电穿孔组织的装置和方法。 至少一个微孔通过组织的表面形成到预定深度，并且在电耦合到微孔的电极和与其间隔开的另一电极之间施加电压。 通过对已经被微孔破坏的组织进行电穿孔，电穿孔作用可以针对表面下方的组织结构，例如毛细管，以大大增强生物流体的抽出，以及将化合物吸收到组织中。 在优选的实施方案中，提供了一种装置，其具有适合于对组织进行微孔化并用作电穿孔电极的元件。
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公开(公告)号：US5792049A
公开(公告)日：1998-08-11
申请号：US906969
申请日：1997-08-06
CPC分类号： G01N21/278 , A61B5/0059 , A61B5/1495 , G01J5/02 , G01J5/021 , G01J5/04 , G01J5/048 , G01J5/522 , A61B2560/0233
摘要： A disposable calibration device is used to calibrate a spectroscopic measurement system which transmits radiation to a material or tissue in order to effect measurements such as bilirubin measurements. The disposable calibration device includes a structure with a window through which radiation can be transmitted, as well as a removable calibration target arranged on the window and capable of returning a portion of the radiation for calibrating the spectrometer system. The removable calibration target can be peeled of the window to allow a measurement to be made on the material or tissue. Once a measurement is complete, the disposable calibration device can be discarded and a new calibration device can be inserted on the spectroscopic system.
摘要翻译： 一次性校准装置用于校准将辐射传输到材料或组织的光谱测量系统，以便进行诸如胆红素测量的测量。 一次性校准装置包括具有可以透射辐射的窗口的结构以及布置在窗口上并且能够返回一部分辐射以用于校准光谱仪系统的可移除校准目标。 可拆卸的校准目标物可以从窗户上剥离，以便对材料或组织进行测量。 一旦测量完成，可以丢弃一次性校准装置，并且可以在光谱系统上插入新的校准装置。
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36.发明授权
公开(公告)号：US5722397A
公开(公告)日：1998-03-03
申请号：US465874
申请日：1995-06-06
申请人： Jonathan A. Eppstein
发明人： Jonathan A. Eppstein
CPC分类号： A61B5/1486 , A61B5/14514 , A61B5/681 , A61K41/0047 , A61K49/22 , A61B18/203 , A61B2017/00172 , A61B2017/00765 , A61B2018/00452 , A61B2018/0047 , A61B2562/0295 , A61M2037/0007 , A61M37/0092
摘要： A method of enhancing the permeability of the skin or mucosa to an analyte for diagnostic purposed is described utilizing ultrasound or ultrasound plus a chemical enhancer. If desired the ultrasound may be modulated by means of frequency modulation, amplitude modulation, phase modulation and/or combinations thereof. A frequency modulation from low to high develops a local pressure gradient directed out of the body, thus permitting analytes in the body to traverse the skin and be collected and measured outside the body. The concentration of an analyte in the body is preferably determined by enhancing the permeability of the skin or other biological membrane optionally with a chemical enhancer, applying ultrasound optionally at a modulated frequency, amplitude, phase, or combinations thereof that further induces a local pressure gradient out of the body, collecting the analyte, and utilizing the analyte collection data calculating the concentration of the analyte in the body.
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37.发明授权
公开(公告)号：US5445611A
公开(公告)日：1995-08-29
申请号：US152174
申请日：1993-12-08
CPC分类号： A61B5/14514 , A61M37/0092 , A61B18/203 , A61B2017/00172 , A61B2017/00765 , A61B2018/00452 , A61B2018/0047
摘要： A method of enhancing the permeability of the skin or mucosa to a biologically active permeant or drug is described utilizing ultrasound or ultrasound plus a chemical enhancer. If desired the ultrasound may be modulated by means of frequency modulation, amplitude modulation, phase modulation and/or combinations thereof. A frequency modulation from high to low develops a local pressure gradient directed into the body, thus permitting permeant to traverse the skin or mucosa. The enhanced delivery is preferably accomplished using a chemical enhancer, applying ultrasound optionally at a modulated frequency, amplitude, phase, or combinations thereof that further induces a local pressure gradient into the body. The method is also useful as a means for application of a tattoo by noninvasively delivering a pigment through the skin surface.
摘要翻译： 使用超声波或超声波加上化学增强剂来描述增强皮肤或粘膜对生物活性透过物或药物的渗透性的方法。 如果需要，可以通过频率调制，幅度调制，相位调制和/或其组合来调制超声波。 从高到低的频率调制产生引导到身体中的局部压力梯度，从而允许透过物穿过皮肤或粘膜。 增强的递送优选使用化学增强剂完成，任选地以调制的频率，幅度，相位或其组合施加超声波，其进一步诱导局部压力梯度进入体内。 该方法也可用作通过非侵入性地通过皮肤表面递送颜料来施加纹身的手段。
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