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公开(公告)号：US11629172B2
公开(公告)日：2023-04-18
申请号：US16721229
申请日：2019-12-19
Applicant: Pfizer Inc.
Inventor： Philip Ralph Dormitzer , Ye Che , Xiaoyuan Sherry Chi , Seungil Han , Kyle Paul Heim , Thomas Richard Jones , Yuhang Liu , Xiayang Qiu , Xinzhen Yang , Xiaojie Yao , Matthew Curtis Griffor , Jennifer Anne Nicki
IPC: C07K14/005 , A61K39/00
Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least one introduced amino acid mutation relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.
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![PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYRROLO[2,3-D]PYRIDINYL ACRYLAMIDES](/abs-image/US/2023/01/12/US20230009153A1/abs.jpg.150x150.jpg)
32.发明申请公开(公告)号：US20230009153A1
公开(公告)日：2023-01-12
申请号：US17393463
申请日：2021-08-04
Applicant: Pfizer Inc.
Inventor： Atli Thorarensen , Matthew Frank Brown , Agustin Casimiro-Garcia , Ye Che , Jotham Wadsworth Coe , Mark Edward Flanagan , Adam Matthew Gilbert , Matthew Merrill Hayward , Jonathan David Langille , Justin Ian Montgomery , Jean-Baptiste Telliez , Rayomand Jal Unwalla , John I. Trujillo
IPC: C07D471/04 , A61K31/4523 , C07D471/08 , C07D487/04 , C07D487/10 , C07D498/04
Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.
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公开(公告)号：US20200247853A1
公开(公告)日：2020-08-06
申请号：US16721229
申请日：2019-12-19
Applicant: Pfizer Inc.
Inventor： Philip Ralph Dormitzer , Ye Che , Xiaoyuan Sherry Chi , Seungil Han , Kyle Paul Heim , Thomas Richard Jones , Yuhang Liu , Xiayang Qiu , Xinzhen Yang , Xiaojie Yao , Matthew Curtis Griffor , Jennifer Anne Nicki
IPC: C07K14/005
Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least one introduced amino acid mutation relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.
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Patent Agency Ranking
公开(公告)号：US20170182151A1
公开(公告)日：2017-06-29
申请号：US15385611
申请日：2016-12-20
Applicant: Pfizer Inc.
Inventor： Ye Che , Philip Ralph Dormitzer , Alexey Vyacheslavovich Gribenko , Luke David Handke , Avvari Krishna Prasad , Xiayang Qiu , Mark Edward Ruppen , Xi Song , Kena Anne Swanson , Srinivas Kodali , Xin Xu , KariAnn Sweeney Efferen , Ping Cai , Kristin Rachael Tompkins , Lorna del Pilar Nunez
IPC: A61K39/155 , C07K14/005 , C12N7/00
CPC classification number: A61K39/155 , A61K39/12 , A61K2039/575 , C07K14/005 , C07K2319/02 , C07K2319/21 , C07K2319/22 , C07K2319/40 , C07K2319/70 , C07K2319/735 , C12N7/00 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571
Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.
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公开(公告)号：US20150182513A1
公开(公告)日：2015-07-02
申请号：US14656123
申请日：2015-03-12
Applicant: Pfizer Inc.
Inventor： Matthew Frank Brown , Ye Che , Anthony Marfat , Michael Joesph Melnick , Justin Ian Montgomery , Usa Reilly
IPC: A61K31/4412 , A61K31/4439
CPC classification number: A61K31/4412 , A61K31/4439 , C07D211/86 , C07D213/64 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/10 , C07D409/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12 , Y02A50/473
Abstract: The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.
Abstract translation: 本发明涉及一类新的异羟肟酸衍生物，它们用作LpxC抑制剂，更具体地说是它们用于治疗细菌感染的用途。
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![PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYR-ROLO[2,3-D]PYRIDINYL ACRYLAMIDES](/abs-image/US/2015/06/11/US20150158864A1/abs.jpg.150x150.jpg)
36.发明申请PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYR-ROLO[2,3-D]PYRIDINYL ACRYLAMIDES 审中-公开吡咯并[2,3-D]吡啶二酮，吡咯并[2,3-b]吡嗪并吡咯并[2,3-D]吡啶-2-基丙烯酰胺公开(公告)号：US20150158864A1
公开(公告)日：2015-06-11
申请号：US14559294
申请日：2014-12-03
Applicant: Pfizer Inc.
Inventor： Atli Thorarensen , Matthew Frank Brown , Agustin Casimiro-Garcia , Ye Che , Jotham Wadsworth Coe , Mark Edward Flanagan , Adam Matthew Gilbert , Matthew Merrill Hayward , Jonathan David Langille , Justin Ian Montgomery , Jean-Baptiste Telliez , Rayomand Jal Unwalla
IPC: C07D471/04 , C07D487/10 , C07D498/04 , C07D487/04 , C07D471/08
CPC classification number: C07D471/04 , C07D471/08 , C07D487/04 , C07D487/10 , C07D498/04
Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.
Abstract translation: 本发明提供药学活性吡咯并[2,3-d]嘧啶基和吡咯并[2,3-d]吡啶基丙烯酰胺及其类似物。 这些化合物可用于抑制Janus Kinase（JAK）。 本发明还涉及包含制备这种化合物的方法的组合物，以及用于治疗和预防由JAK介导的病症的方法。
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公开(公告)号：US09018384B2
公开(公告)日：2015-04-28
申请号：US14447788
申请日：2014-07-31
Applicant: Pfizer Inc.
Inventor： Matthew Frank Brown , Ye Che , Anthony Marfat , Michael Joesph Melnick , Justin Ian Montgomery , Usa Reilly
IPC: A61K31/44 , C07D401/00 , C07D213/64 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/10 , C07D409/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12 , C07D211/86 , C07D403/04 , C07D401/14
CPC classification number: A61K31/4412 , A61K31/4439 , C07D211/86 , C07D213/64 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/10 , C07D409/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12 , Y02A50/473
Abstract: The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.
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公开(公告)号：US20140343031A1
公开(公告)日：2014-11-20
申请号：US14447788
申请日：2014-07-31
Applicant: Pfizer Inc.
Inventor： Matthew Frank Brown , Ye Che , Anthony Marfat , Michael Joesph Melnick , Justin Ian Montgomery , Usa Reilly
IPC: C07D213/64 , C07D401/12 , C07D401/14 , C07D401/04 , C07D413/10 , C07D401/10 , C07D405/04
CPC classification number: A61K31/4412 , A61K31/4439 , C07D211/86 , C07D213/64 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/10 , C07D409/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12 , Y02A50/473
Abstract: The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.
Abstract translation: 本发明涉及一类新的异羟肟酸衍生物，它们用作LpxC抑制剂，更具体地说是它们用于治疗细菌感染的用途。
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