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    REGULATION OF SKIN PIGMENTATION BY NEUREGULIN-1 (NRG-1)
    31.
    发明申请
    REGULATION OF SKIN PIGMENTATION BY NEUREGULIN-1 (NRG-1) 有权
    神经细胞-1（NRG-1）皮肤色素调节

    公开(公告)号：US20130095053A1

    公开(公告)日：2013-04-18

    申请号：US13805638

    申请日：2011-06-23

    申请人： Vincent J. Hearing ,  Wonseon Choi ,  Ludger Kolbe ,  Rainer Wolber

    发明人： Vincent J. Hearing ,  Wonseon Choi ,  Ludger Kolbe ,  Rainer Wolber

    IPC分类号： A61K39/395 ,  A61K38/10 ,  A61K38/08 ,  A61K31/7105

    CPC分类号： A61K39/3955 ,  A61K31/7105 ,  A61K38/08 ,  A61K38/10 ,  A61K38/1883 ,  C07K14/4756

    摘要： Disclosed herein are compositions and methods of using such compositions to modulate pigmentation and proliferation of a melanocyte, such as to prevent or treat skin disorders, including skin cancer or for use for cosmetic purposes. In one example, a method of modulating pigmentation of a melanocyte includes contacting the melanocyte (such as a human melanocyte) with an agent that modulates neuregulin-1 (NRG-1) activity, such as an agent that increases or decreases NRG-1 activity, thereby modulating pigmentation of the melanocyte. In one particular example, the method of increasing melanocyte pigmentation or proliferation can be used to reduce UV skin damage, including that associated with skin cancer. In another example, the method of decreasing melanocyte pigmentation can be used to treat a skin pigmentation disorder associated with undesired increased skin pigmentation.

    摘要翻译： 本文公开了使用这种组合物调节黑素细胞的色素沉着和增殖的组合物和方法，例如预防或治疗皮肤病，包括皮肤癌或用于美容目的。 在一个实例中，调节黑素细胞色素沉着的方法包括将黑素细胞（例如人黑素细胞）与调节神经调节蛋白-1（NRG-1）活性的试剂接触，例如增加或减少NRG-1活性的试剂 ，从而调节黑素细胞的色素沉着。 在一个具体实例中，增加黑素细胞色素沉着或增殖的方法可用于减少UV皮肤损伤，包括与皮肤癌相关的损伤。 在另一个实例中，减少黑素细胞色素沉着的方法可用于治疗与不期望的增加的皮肤色素沉着相关的皮肤色素沉着紊乱。