公开(公告)号：US08063103B2

公开(公告)日：2011-11-22

申请号：US12556235

申请日：2009-09-09

申请人： James Prentice Davidson ,  Fei Pang ,  Margaret Wong ,  Michael Martin

发明人： James Prentice Davidson ,  Fei Pang ,  Margaret Wong ,  Michael Martin

IPC分类号： C07C311/51 ,  A61K31/277

CPC分类号： C07C311/51 ,  A61K31/18 ,  C07B2200/13

摘要： The application discloses novel polymorphic crystalline forms of 2-[4-Bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-propionylsulfamoyl-phenyl)-acetamide, sodium salt (Ib) with improved stability and physical properties which facilitate manufacturing, handling and formulating for treatment or prophylaxis of HIV mediated diseases, AIDS or ARC, in monotherapy or in combination therapy.

摘要翻译： 该申请公开了2- [4-溴-3-（3-氯-5-氰基 - 苯氧基）-2-氟 - 苯基] -N-（2-氯-4-丙酰基氨磺酰基 - 苯基） - 乙酰胺，钠盐（Ib），具有改善的稳定性和物理性质，便于在单一疗法或联合治疗中制备，处理和配制用于治疗或预防HIV介导的疾病，AIDS或ARC。

公开(公告)号：US20110172228A1

公开(公告)日：2011-07-14

申请号：US13002438

申请日：2009-07-08

申请人： Pingda Ren ,  Yi Liu ,  Troy Edward Wilson ,  Liansheng Li ,  Katrina Chan ,  Michael Martin ,  Christian Rommel

发明人： Pingda Ren ,  Yi Liu ,  Troy Edward Wilson ,  Liansheng Li ,  Katrina Chan ,  Michael Martin ,  Christian Rommel

IPC分类号： A61K31/5377 ,  C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P19/08 ,  A61P29/00 ,  A61P35/02 ,  A61P9/00 ,  A61P3/00 ,  A61P11/00 ,  A61P25/00

CPC分类号： C07D487/04 ,  A61K31/505 ,  A61K31/519 ,  A61K31/52 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00

摘要： The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. Also provided in the present invention are methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications.

摘要翻译： 本发明提供能够调节某些蛋白激酶例如mTor，酪氨酸激酶和/或脂质激酶例如PI3激酶的化学​​实体或其化合物及其药物组合物。 本发明还提供了使用这些组合物调节这些激酶中的一种或多种，​​特别是用于治疗应用的活性的方法。

公开(公告)号：US20100252522A1

公开(公告)日：2010-10-07

申请号：US12596605

申请日：2008-04-21

申请人： Frank Conrad ,  Jürgen Appel ,  Peter Orfey ,  Roland Kuhn ,  Michael Martin ,  Udo Biwer ,  Klaus Conrad

发明人： Frank Conrad ,  Jürgen Appel ,  Peter Orfey ,  Roland Kuhn ,  Michael Martin ,  Udo Biwer ,  Klaus Conrad

IPC分类号： B66C23/66 ,  B66C23/70 ,  B23P11/00

CPC分类号： B66C23/82 ,  Y10T29/49826

摘要： An auxiliary device for equipping the main boom of a mobile crane with an auxiliary boom, wherein a support is mounted near the head of the main boom, by means of which the lifting cable of the main boom may be run to a connection point on the auxiliary boom. The invention further relates to a method for equipping with an auxiliary boom.

摘要翻译： 一种辅助装置，用于配备具有辅助起重臂的移动式起重机的主起重臂，其中支撑件安装在主起重臂的头部附近，通过该支撑件，主起重臂的提升缆绳可以运行到连接点 辅助繁荣。 本发明还涉及一种用于装备辅助起重臂的方法。

公开(公告)号：US20100175786A1

公开(公告)日：2010-07-15

申请号：US12353379

申请日：2009-01-14

申请人： Michael Martin

发明人： Michael Martin

IPC分类号： B67D5/375 ,  B67D5/37 ,  B65B3/04 ,  G05G5/06

CPC分类号： B67D7/50 ,  Y10T74/20612

摘要： A gas pump nozzle handle block and method of use for maintaining an open flow position until the valve senses the back pressure to shut off the flow of gas, the block dimensioned so as to slide within an opening of the nozzle handle, and rotated within the opening so as to frictionally engage a bottom side of the block against an upper side of the nozzle handle below the opening of the handle and to further frictionally engage an upper side of the block against an undersurface of a valve operating lever and to push the lever toward a lower side of the nozzle handle above the opening of the nozzle handle, thereby maintaining the operating lever in an open flow position until the nozzle valve senses a back pressure to shut off a flow of gas through the nozzle valve.

摘要翻译： 一种气泵喷嘴手柄块和用于保持开放流动位置的方法，直到阀感测到背压以截止气体流动，该块的尺寸被设计成在喷嘴手柄的开口内滑动，并在 开口以摩擦地将块的底侧摩擦地接合在手柄的开口下方的喷嘴手柄的上侧，并且进一步摩擦地将块的上侧接合在阀操作杆的下表面上并推动杆 朝向喷嘴手柄的开口上方的喷嘴手柄的下侧，从而将操作杆保持在打开的流动位置，直到喷嘴阀感测到背压以截止通过喷嘴阀的气体流动。

公开(公告)号：US07651209B2

公开(公告)日：2010-01-26

申请号：US11180281

申请日：2005-07-13

申请人： Paul Mark Haines ,  Mark A. Devries ,  Michael Martin

发明人： Paul Mark Haines ,  Mark A. Devries ,  Michael Martin

IPC分类号： B41J2/175

CPC分类号： B41J2/17546 ,  B41J2/17513 ,  B41J2/19

摘要： In one embodiment, an ink pen includes an ink chamber, a passage and a printhead operatively connected to the ink chamber through the passage such that ink flowing from the ink chamber to the printhead passes through the passage. The passage includes an upstream part having a polygonal cross sectional area and a downstream part having a cross sectional area smaller than the polygonal cross sectional area.

摘要翻译： 在一个实施例中，墨水笔包括墨水室，通道和通过通道可操作地连接到墨水室的打印头，使得从墨水室流到打印头的墨水通过通道。 通道包括具有多边形横截面积的上游部分和具有小于多边形横截面积的横截面面积的下游部分。

公开(公告)号：US20090179103A1

公开(公告)日：2009-07-16

申请号：US11972661

申请日：2008-01-11

申请人： Michael Martin ,  David Thiessen

发明人： Michael Martin ,  David Thiessen

IPC分类号： B65H23/08

CPC分类号： B65H16/028 ,  B65B13/18 ,  B65H16/005 ,  B65H2301/41386 ,  B65H2405/422

摘要： Device for dispensing strapping material from a coil of the strapping material includes a carriage for receiving the coil of material such that the coil can be rotated about a longitudinal axis of the coil by pulling the material from the coil to unwind the material from the coil. The carriage supports the coil at circumferential spaced locations on the periphery of the coil, is adjustable to various widths or thickness of the coil, and operates to apply a proportional braking force to the coil at circumferential spaced locations on the periphery of the coil as a function of the weight of the coil. The carriage is mounted to a wheeled cart that includes various receivers for storing tools and supplies used in the process of bundling articles together with strapping.

摘要翻译： 用于从捆扎材料的线圈分配捆扎材料的装置包括用于接收材料线圈的托架，使得线圈可以绕线圈的纵向轴线旋转，通过从线圈拉出材料以将材料从线圈展开。 滑架在线圈周边的圆周间隔位置处支撑线圈，可调节到线圈的各种宽度或厚度，并且操作以在线圈周边上的圆周间隔位置处向线圈施加比例制动力，作为线圈 线圈重量的函数。 托架被安装到轮式推车上，其包括各种接收器，用于存储用于将物品捆扎在一起的捆扎过程中使用的工具和用品。

公开(公告)号：US20070108965A1

公开(公告)日：2007-05-17

申请号：US11623505

申请日：2007-01-16

申请人： Michael Martin ,  Brett Crump

发明人： Michael Martin ,  Brett Crump

IPC分类号： G01R31/28

CPC分类号： G01R31/2893 ,  G01R1/07314 ,  G01R1/07378

摘要： Maintaining proper planarity of elements of a microelectronic component test system helps ensure reliable operation of the test system. Aspects of the invention provide test systems and methods for verifying planarity of, for example, a head and a support surface of a microelectronic component test system. In one exemplary method, a probe card is mounted to and electrically coupled to a head of a microelectronic component test system. The probe card has an array of probes. A contact surface of the support is moved with respect to the head and a change in contact condition of each of the probes is recorded in a first data set. The orientation of the probe card with respect to the contact surface is changed, the contact surface is moved with respect to the head again and a change in contact condition of each of the probes is recorded in a second data set.

摘要翻译： 保持微电子元件测试系统元件的正确平面性有助于确保测试系统的可靠运行。 本发明的方面提供了用于验证例如微电子部件测试系统的头部和支撑表面的平坦度的测试系统和方法。 在一个示例性方法中，探针卡安装到电耦合到微电子部件测试系统的头部。 探针卡有一个探针阵列。 支撑件的接触表面相对于头移动，并且每个探针的接触状态的变化记录在第一数据集中。 探针卡相对于接触表面的方向改变，接触表面再次相对于头部移动，并且每个探针的接触状态的变化被记录在第二数据组中。

公开(公告)号：US07182125B2

公开(公告)日：2007-02-27

申请号：US10724481

申请日：2003-11-28

申请人： Michael Martin ,  Alan Wu ,  Tim Miller

发明人： Michael Martin ,  Alan Wu ,  Tim Miller

IPC分类号： F28F13/12

CPC分类号： F28D1/0383 ,  F28F13/12

摘要： A multi-pass heat exchanger including first and second plates forming a fluid chamber therebetween having an inlet opening and an outlet opening, and a turbulizer plate having rows of fluid flow augmenting convolutions in the fluid chamber, the turbulizer plate including at least one barrier dividing the fluid chamber into first and second pass regions such that fluid flowing in the fluid chamber flows around an end of the barrier when flowing from the first pass region to the second pass regions, the turbulizer plate having portions defining a notch area therebetween for fluid to pass through when flowing in the fluid chamber around the end of the barrier from the first pass region to the second pass region.

摘要翻译： 一种多通道热交换器，包括在其间形成流体室的第一和第二板，其间具有入口和出口，以及在流体室中具有一排流体流动增大卷积的紊流板，所述湍流板包括至少一个阻挡分隔 所述流体室进入第一和第二通过区域，使得在所述流体室中流动的流体在从所述第一通过区域流动到所述第二通过区域时围绕所述阻挡件的端部流动，所述湍流器板具有限定其间的切口面积的流体到 在从第一通过区域到第二通过区域的阻挡层的端部周围的流体室中流动时通过。

公开(公告)号：US20070024689A1

公开(公告)日：2007-02-01

申请号：US11192129

申请日：2005-07-29

申请人： Todd Preston ,  Richard Kalb ,  James Spence ,  Wayne Drinkwater ,  Michael Martin ,  Robert Pictor

发明人： Todd Preston ,  Richard Kalb ,  James Spence ,  Wayne Drinkwater ,  Michael Martin ,  Robert Pictor

IPC分类号： B41J2/385

CPC分类号： B41J2/0057 ,  G03G15/0121 ,  G03G2215/0119

摘要： Systems and methods of a multiple dispensing system may include an image carrier, and may include a plurality of substantially aligned developing units positioned to develop image information on the image carrier. Each developing unit may include only one ink container and only one developer housing. The systems and method may also include a first dispensing system positioned upstream in a sheet feed direction of the plurality of substantially aligned developing units. The first dispensing system may include a first ink container and a first developer housing. The first developer housing may be configured to receive first imaging media from the first ink container and second imaging media from at least one other ink supply source.

摘要翻译： 多分配系统的系统和方法可以包括图像载体，并且可以包括多个基本对准的显影单元，定位成在图像载体上显影图像信息。 每个显影单元可以仅包括一个墨水容器和仅一个显影剂外壳。 系统和方法还可以包括位于多个基本对齐的显影单元的纸张进给方向上游的第一分配系统。 第一分配系统可以包括第一墨水容器和第一显影剂外壳。 第一显影剂外壳可以被配置为从第一墨水容器和第二成像介质从至少一个其它墨水供应源接收第一成像介质。

公开(公告)号：US20060232259A1

公开(公告)日：2006-10-19

申请号：US11106894

申请日：2005-04-15

申请人： Mark Olsson ,  Michael Martin ,  Christoph Maier ,  Paul Stuart

发明人： Mark Olsson ,  Michael Martin ,  Christoph Maier ,  Paul Stuart

IPC分类号： G01R19/00

CPC分类号： G01R29/0871 ,  G01R29/0878 ,  G01V3/15

摘要： A human-portable utility locator system for locating and tracing a buried utility line characterized by an electromagnetic field emission. The locator may include a horizontal spaced sensor pair for detecting the horizontal field asymmetry of the emitted field in one or more independent frequency bands, which is employed to assist in determining an accurate “virtual depth” measurement for producing detection events. An event detector may be disposed to detect events corresponding to extremum in the B-field gradient with respect to time and a user interface (UI) coupled to the event detector signals the detected event to a user. In a preferred embodiment, one pair of spaced-apart 3D magnetic sensor arrays is disposed substantially orthogonal to another intermediate spaced-apart pair of sensors.

摘要翻译： 一种人造便携式实用定位系统，用于定位和跟踪以电磁场发射为特征的埋地公用事业线。 定位器可以包括用于检测一个或多个独立频带中的发射场的水平场不对称性的水平间隔传感器对，其用于帮助确定用于产生检测事件的精确“虚拟深度”测量。 可以设置事件检测器以相对于时间检测对应于B场梯度中的极值的事件，并且耦合到事件检测器的用户界面（UI）将检测到的事件发信号给用户。 在优选实施例中，一对间隔开的3D磁传感器阵列基本上与另一中间间隔开的传感器对正交设置。