公开(公告)号：US08765385B2

公开(公告)日：2014-07-01

申请号：US13283552

申请日：2011-10-27

Applicant: Ravindra Kumar ,  Asya Grinberg ,  Monique Davies ,  Diana Martik ,  Janja Cosic ,  Rachel Kent ,  David Buckler

Inventor： Ravindra Kumar ,  Asya Grinberg ,  Monique Davies ,  Diana Martik ,  Janja Cosic ,  Rachel Kent ,  David Buckler

IPC: G01N33/53 ,  A61K39/395

CPC classification number: C07K16/2863 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

Abstract: The disclosure provides, among other aspects, neutralizing antibodies and portions thereof that bind to ActRIIB and uses for same.

Abstract translation: 本公开尤其提供了中和抗体及其与ActRIIB结合并用于其的部分。

公开(公告)号：US08642031B2

公开(公告)日：2014-02-04

申请号：US12467170

申请日：2009-05-15

Applicant: Jasbir Seehra ,  John Knopf ,  Robert S. Pearsall ,  Asya Grinberg ,  Ravindra Kumar

Inventor： Jasbir Seehra ,  John Knopf ,  Robert S. Pearsall ,  Asya Grinberg ,  Ravindra Kumar

IPC: A61K39/395

CPC classification number: C07K16/22 ,  A61K9/0048 ,  A61K38/1709 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/71 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. In certain aspects, the disclosure demonstrates that antagonists of BMP9 and/or BMP10, ligands for ALK1, may also be used to inhibit angiogenesis in vivo.

Abstract translation: 在某些方面，本公开涉及以下认识：包含活化素样激酶I（ALK1）多肽的细胞外结构域的配体结合部分的多肽可用于抑制体内血管发生，特别是在血管生成相关的哺乳动物中 疾病 在某些方面，本公开表明BMP9和/或BMP10的拮抗剂，ALK1的配体也可用于抑制体内血管发生。

公开(公告)号：US08058229B2

公开(公告)日：2011-11-15

申请号：US12583177

申请日：2009-08-13

Applicant: Jasbir Seehra ,  Robert Scott Pearsall ,  Ravindra Kumar

Inventor： Jasbir Seehra ,  Robert Scott Pearsall ,  Ravindra Kumar

IPC: A61K38/00 ,  A61P7/00 ,  C07K14/435

CPC classification number: C12N9/12 ,  A61K38/179 ,  A61K38/1796 ,  C07K14/47 ,  C07K14/475 ,  C07K2319/30 ,  C12Q1/6897 ,  C12Y207/1103

Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

Abstract translation: 在某些方面，本发明提供用于增加脊椎动物（包括啮齿动物和灵长类动物，特别是人）中红细胞和/或血红蛋白水平的组合物和方法。

公开(公告)号：US08051113B1

公开(公告)日：2011-11-01

申请号：US12561592

申请日：2009-09-17

Applicant: Raja Shekar ,  Ravindra Kumar ,  Kartik Kumar

Inventor： Raja Shekar ,  Ravindra Kumar ,  Kartik Kumar

IPC: G06F17/30

CPC classification number: G06F17/30067 ,  H04L12/1435 ,  H04L41/12 ,  H04L41/22 ,  H04L43/0817 ,  H04L67/1097

Abstract: Method and system for managing a storage environment having a cluster based storage system and a non-cluster based storage system is provided. A management application collects information regarding components of both the cluster based storage system and the non-cluster based storage system. A layout having a plurality of data structures is generated and maintained by the management application. The data structures include information regarding the components and their relationships with each other, if any. The layout is used for responding to user requests and presenting an integrated view of the storage environment on a display device with selectable options for selecting the cluster based storage system components and the non-cluster based storage system components.

Abstract translation: 提供了一种用于管理具有基于群集的存储系统和基于非群集的存储系统的存储环境的方法和系统。 管理应用程序收集有关基于群集的存储系统和基于非群集的存储系统的组件的信息。 具有多个数据结构的布局由管理应用程序生成和维护。 数据结构包括关于组件及其彼此之间的关系的信息（如果有的话）。 该布局用于响应用户请求，并在显示设备上呈现存储环境的集成视图，其具有用于选择基于群集的存储系统组件和基于非群集的存储系统组件的可选择选项。

公开(公告)号：US07927835B2

公开(公告)日：2011-04-19

申请号：US12167680

申请日：2008-07-03

Applicant: Glenn R. Larsen ,  Dianne S. Sako ,  Xiao-Jia Chang ,  Geertruida M. Veldman ,  Dale Cumming ,  Ravindra Kumar ,  Gray Shaw

Inventor： Glenn R. Larsen ,  Dianne S. Sako ,  Xiao-Jia Chang ,  Geertruida M. Veldman ,  Dale Cumming ,  Ravindra Kumar ,  Gray Shaw

IPC: C07H21/04 ,  C12N15/00 ,  C12N15/11

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4703 ,  C07K14/51 ,  C07K14/52 ,  C07K14/5431 ,  C07K14/705 ,  C07K16/2851 ,  C07K16/2854 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/24 ,  C12N9/10 ,  C12N9/1051 ,  C12N9/6454 ,  C12N2770/36222

Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.

Abstract translation: 公开了一种新型P-选择素配体糖蛋白，其包含SEQ ID NO：2所示的氨基酸序列或SEQ ID NO：4所示的氨基酸序列。 还公开了编码P-选择素配体蛋白的DNA序列，以及载体，宿主细胞和制备P-选择蛋白配体蛋白的方法。 还公开了含有P-选择素配体蛋白质的药物组合物和治疗由P-选择蛋白和E-选择素介导的细胞间粘附特征的炎性疾病状态的方法。

公开(公告)号：US07926049B1

公开(公告)日：2011-04-12

申请号：US11388174

申请日：2006-03-23

Applicant: Ravindra Kumar

Inventor： Ravindra Kumar

IPC: G06F9/45

CPC classification number: G06F9/44505

Abstract: A system and method for determining differences between configurations of a software program. A configuration differencing command generates a hash table of configuration keys and values for each of the configurations being compared. A key is selected from a first hash table and the command determines if an identical key exists in the second hash table. If the key exists in the second hash table, a comparison is made of the values associated with the keys and, if the values are not identical, the configuration differencing command displays the differences to an administrator.

Abstract translation: 一种用于确定软件程序的配置之间的差异的系统和方法。 配置差异命令为每个正在比较的配置生成配置密钥和值的哈希表。 从第一散列表中选择密钥，并且该命令确定在第二哈希表中是否存在相同的密钥。 如果密钥存在于第二个哈希表中，则对与密钥相关的值进行比较，如果值不相同，则配置差异命令将显示与管理员的差异。

公开(公告)号：US20110046057A1

公开(公告)日：2011-02-24

申请号：US12940740

申请日：2010-11-05

Applicant: Asya Grinberg ,  John Knopf ,  Ravindra Kumar ,  Jasbir Seehra

Inventor： Asya Grinberg ,  John Knopf ,  Ravindra Kumar ,  Jasbir Seehra

IPC: A61K38/19 ,  C07K14/52 ,  A61P21/00

CPC classification number: C07K14/475 ,  A61K38/00 ,  A61K38/179

Abstract: The disclosure relates to Cerberus/Coco polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11.

Abstract translation: 本公开涉及用于治疗与肌生长抑制素，结节和GDF-11相关的多种疾病的Cerberus / Coco多肽或其变体。

公开(公告)号：US20100310577A1

公开(公告)日：2010-12-09

申请号：US12796332

申请日：2010-06-08

Applicant: John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

Inventor： John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

IPC: A61K39/395 ,  A61K38/16 ,  A61K31/7088 ,  A61K38/18 ,  A61P3/00

CPC classification number: C07K16/40 ,  A61K31/7088 ,  A61K38/00 ,  A61K38/1796 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P21/00 ,  C07K14/71 ,  C07K2319/30 ,  C12N5/0602

Abstract: In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Nodal, anti-activin, and anti-GDF11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.

Abstract translation: 在某些方面，本发明提供通过施用ActRIIB信号传导途径的拮抗剂来增加产热脂肪细胞（例如，棕色脂肪细胞或其他表达UCP-1的脂肪细胞）的组合物和方法。 这些拮抗剂的实例包括ActRIIB多肽，抗ActRIIB抗体，抗肌生成抑制素抗体，抗GDF3抗体，抗淋巴结，抗激活素和抗GDF11抗体。 可以通过引起生热脂肪细胞的增加来治疗各种代谢和其它疾病。

公开(公告)号：US07842663B2

公开(公告)日：2010-11-30

申请号：US12012652

申请日：2008-02-04

Applicant: John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

Inventor： John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

IPC: A61K38/00 ,  A61K38/16 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71

CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C07K16/18 ,  C07K2319/30 ,  C07K2319/70

Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.

Abstract translation: 在某些方面，本发明提供用于调节（促进或抑制）组织如骨，软骨，肌肉，脂肪和/或神经元组织的生长的组合物和方法。 本发明还提供筛选调节ActRIIB蛋白和/或ActRIIB配体的活性的化合物的方法。 本文提供的组合物和方法可用于治疗与ActRIIB蛋白和/或ActRIIB配体的异常活性相关的疾病。

公开(公告)号：US20100166550A1

公开(公告)日：2010-07-01

申请号：US12347329

申请日：2008-12-31

Applicant: Siddaraja M. Devangada ,  Ravindra Kumar

Inventor： Siddaraja M. Devangada ,  Ravindra Kumar

IPC: F01D9/02 ,  B23P15/02

CPC classification number: F01D5/16 ,  F01D5/26 ,  F01D9/041 ,  Y10T29/49336

Abstract: A method of tuning a compressor stator blade, having a base portion and an airfoil portion, to achieve a desired natural frequency, comprising: a) identifying the natural frequency of the compressor stator blade; b) determining a different target natural frequency for the compressor stator blade; and c) removing material from at least one of the side surfaces of the base portion of the compressor stator blade in an amount and in a configuration that achieves the target natural frequency.

Abstract translation: 一种调节压缩机定子叶片的方法，所述压缩机定子叶片具有基部和翼型部分，以实现期望的固有频率，包括：a）识别压缩机定子叶片的固有频率; b）确定压缩机定子叶片的不同目标固有频率; 以及c）以达到目标固有频率的量和配置从所述压缩机定子叶片的基部的至少一个侧表面去除材料。