Use of ophthalmic compositions including lubricant, deturgescent agent, and glycosaminoglycan
    31.
    发明授权
    Use of ophthalmic compositions including lubricant, deturgescent agent, and glycosaminoglycan 有权
    使用包括润滑剂,止痒剂和糖胺聚糖在内的眼用组合物

    公开(公告)号:US09233123B1

    公开(公告)日:2016-01-12

    申请号:US12928226

    申请日:2010-12-07

    摘要: Ophthalmic compositions including lubricant agent, deturgescent agent, glycosaminoglycan, and water are used to preserve tissue in vitro; for example, ocular tissue, especially a cornea, thereby facilitating subsequent transplant, especially of a complete cornea. Preferably, the ophthalmic composition and tissue are stored at about 0° C. to about 40° C. The ophthalmic solution may be replaced on either a continuous basis or batch exchanged. The volume of ophthalmic solution per individual cornea being preserved would be from about 50 ml to about 500 ml.

    摘要翻译: 包括润滑剂,止痒剂,糖胺聚糖和水在内的眼用组合物用于体外保存组织; 例如眼组织,特别是角膜,从而促进随后的移​​植,特别是完整的角膜移植。 优选地,眼科组合物和组织在约0℃至约40℃下储存。眼用溶液可以在连续的基础上或间歇更换的方式进行更换。 保存的每个角膜的眼用溶液体积为约50ml至约500ml。

    Accomodative intraocular lens
    32.
    发明授权
    Accomodative intraocular lens 有权
    住院眼内镜

    公开(公告)号:US08858627B1

    公开(公告)日:2014-10-14

    申请号:US12584689

    申请日:2009-09-10

    IPC分类号: A61F2/16

    摘要: An accommodative intraocular lens having a soft deformable resilient inner lens portion or core with an exposed anterior inner optic surface and exposed posterior optic surface, the surfaces responsively becoming simultaneously optically steeper and moving axially away from each other. The exposed anterior and posterior surfaces of the inner lens portions may be spherically shaped or aspherically shaped and the shape of the outer lens portion may be spherically or aspherically shaped.

    摘要翻译: 一种调节性眼内透镜,其具有柔软的可变形弹性内透镜部分或具有暴露的前内光学表面和暴露的后光学表面的芯,所述表面响应地变得同时光学更陡峭并且彼此轴向移动。 内透镜部分的暴露的前表面和后表面可以是球形或非球面形状,并且外透镜部分的形状可以是球形或非球面形状。

    Targeted eye drop dispenser
    34.
    发明授权
    Targeted eye drop dispenser 失效
    目标滴眼剂

    公开(公告)号:US5558653A

    公开(公告)日:1996-09-24

    申请号:US484073

    申请日:1995-06-07

    IPC分类号: A61F9/00 A61M35/00 B65D5/66

    CPC分类号: A61F9/0008

    摘要: Targeted eye drop dispenser having concentric target rings of highly colored material aligned over and about the dispensing orifice. Highly visible material target rings aid in alignment of the dispensing orifice over the center of the human eye for self-dispensing of eye drops by the user of the targeted eye drop dispenser. An alternative embodiment includes a lighted target area.

    摘要翻译: 针对性的滴眼剂分配器具有高度着色的材料的同心目标环,在分配孔上方和周围对齐。 高度可见的材料目标环有助于将分配孔对准人眼的中心,以便由目标眼药水分配器的用户自行分配眼药水。 替代实施例包括点亮的目标区域。

    Non-primate vitreal replacement process
    35.
    发明授权
    Non-primate vitreal replacement process 失效
    非灵长类玻璃体替代过程

    公开(公告)号:US5385723A

    公开(公告)日:1995-01-31

    申请号:US765427

    申请日:1991-09-25

    IPC分类号: A61K49/00

    CPC分类号: A61K49/00 Y10S514/912

    摘要: This is a non-primate vitreal replacement process that quantitates the inflammatory response to viscoelastic agents or solutions. More specifically, the rabbit vitreal replacement process consists of the surgical replacement of a small volume of the central gel vitreous of the rabbit with a viscoelastic agent or solution, and measuring the invasion of white blood cells in the vitreous and anterior chamber at 48 hours post injection. Additional parameters measured are anterior chamber flare, haze and flare in the vitreal chamber, ocular fundus clarity, presence of iris congestion, lens involvement, corneal clarity, conjunctival congestion and conjunctival swelling. In this process, the rabbit is evaluated prior to injection of the viscoelastic agent or solution and 48 hours post injection. Each parameter is evaluated on a scale of 0 to 5. A non-inflammatory sample consists of a mean total score of equal to or less than one or a vitreal cell count less than 50 cells/mm.sup.3. This is an extremely sensitive system for detecting small amounts of inflammatory agents in viscoelastic agents or solutions. The test solution is rated as acceptable for veterinary or human use if a non-inflammatory response is obtained in this process.

    摘要翻译: 这是非灵长类玻璃体替代过程,其定量为粘弹剂或溶液的炎症反应。 更具体地,兔子玻璃体替代过程包括用粘弹性剂或溶液手术置换少量兔中心凝胶玻璃体,并在48小时后测量玻璃体和前房中白细胞的侵入 注射。 测量的附加参数是玻璃体腔中的前房耀斑,浑浊和耀斑,眼底清晰度,虹膜充血的存在,镜片参与,角膜清晰度,结膜充血和结膜肿胀。 在该过程中,在注射粘弹剂或溶液之前和注射后48小时评价兔子。 每个参数以0至5的等级进行评估。非炎性样品由等于或小于1的平均总分数或小于50个细胞/ mm 3的玻璃体细胞计数组成。 这是一种非常敏感的系统,用于在粘弹剂或溶液中检测少量的炎症因子。 如果在该过程中获得非炎症反应,则测试溶液被评为兽医或人类可接受的。

    Corneal implant lens with fixation holes
    36.
    发明授权
    Corneal implant lens with fixation holes 失效
    角膜植入物镜片带固定孔

    公开(公告)号:US4851003A

    公开(公告)日:1989-07-25

    申请号:US141117

    申请日:1988-01-05

    IPC分类号: A61F2/14 A61L27/34

    摘要: Intracorneal or epicorneal lens with a plurality of fixation holes spaced about the outer circumference of the lens. The lens can be of a soft material, such as hydrogel, a high refractive index material such as polysulfone, polycarbonate, or polyethylene, or any other material. The lens can also be coated with any suitable material, such as hydrogel or glycosaminoglycan.

    摘要翻译: 具有围绕透镜的外圆周间隔开的多个固定孔的角膜内或背景透镜。 透镜可以是软质材料,例如水凝胶,高折射率材料如聚砜,聚碳酸酯或聚乙烯,或任何其它材料。 透镜还可以涂覆任何合适的材料,如水凝胶或糖胺聚糖。

    Intracorneal lens
    37.
    发明授权
    Intracorneal lens 失效
    角内镜

    公开(公告)号:US4799931A

    公开(公告)日:1989-01-24

    申请号:US863049

    申请日:1986-05-14

    摘要: An intracorneal lens with at least one hole such as central pinhole, or a, plurality of pinholes or the like; and, a material filling the holes or a material filling the pinholes, and coating the lens. The intracorneal lens can be of any high index of refraction material. The material filling the holes as well as coating the lens can be a gas permeable polymer or metabolite permeable material, a biocompatible polymer or biocompatible material, or a neutral or negatively charged material.

    摘要翻译: 具有至少一个孔(例如中心针孔)或多个针孔等的角内透镜; 以及填充孔的材料或填充针孔的材料,以及涂覆透镜。 角内镜片可以是任何高折射率材料。 填充孔以及涂覆透镜的材料可以是透气聚合物或代谢物可渗透材料,生物相容性聚合物或生物相容性材料,或中性或带负电荷的材料。

    Epicorneal lens
    38.
    发明授权
    Epicorneal lens 失效
    Epicorneal镜片

    公开(公告)号:US4715858A

    公开(公告)日:1987-12-29

    申请号:US889174

    申请日:1986-07-25

    IPC分类号: A61F2/14

    CPC分类号: A61F2/142 A61F2/14

    摘要: A synthetic epicorneal lens for use in the treatment of refractive errors. The lens is of a plastic that is compatible with the cornea, may be gas permeable or metabolite permeable, and may be coated with a basement membrane material such as fibronectin or laminen. The lens can be made from polymers, hydrogel, silicone, fluoropolymer, cellulose acetate butyrate, or other like material.

    摘要翻译: 用于治疗屈光不正的合成上皮膜镜片。 透镜是与角膜相容的塑料,可以是透气的或代谢物可渗透的,并且可以用基底膜材料如纤连蛋白或层粘连涂层。 透镜可以由聚合物,水凝胶,硅酮,含氟聚合物,乙酸丁酸纤维素或其它类似材料制成。