摘要:
Ophthalmic compositions including lubricant agent, deturgescent agent, glycosaminoglycan, and water are used to preserve tissue in vitro; for example, ocular tissue, especially a cornea, thereby facilitating subsequent transplant, especially of a complete cornea. Preferably, the ophthalmic composition and tissue are stored at about 0° C. to about 40° C. The ophthalmic solution may be replaced on either a continuous basis or batch exchanged. The volume of ophthalmic solution per individual cornea being preserved would be from about 50 ml to about 500 ml.
摘要:
An accommodative intraocular lens having a soft deformable resilient inner lens portion or core with an exposed anterior inner optic surface and exposed posterior optic surface, the surfaces responsively becoming simultaneously optically steeper and moving axially away from each other. The exposed anterior and posterior surfaces of the inner lens portions may be spherically shaped or aspherically shaped and the shape of the outer lens portion may be spherically or aspherically shaped.
摘要:
A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.
摘要:
Targeted eye drop dispenser having concentric target rings of highly colored material aligned over and about the dispensing orifice. Highly visible material target rings aid in alignment of the dispensing orifice over the center of the human eye for self-dispensing of eye drops by the user of the targeted eye drop dispenser. An alternative embodiment includes a lighted target area.
摘要:
This is a non-primate vitreal replacement process that quantitates the inflammatory response to viscoelastic agents or solutions. More specifically, the rabbit vitreal replacement process consists of the surgical replacement of a small volume of the central gel vitreous of the rabbit with a viscoelastic agent or solution, and measuring the invasion of white blood cells in the vitreous and anterior chamber at 48 hours post injection. Additional parameters measured are anterior chamber flare, haze and flare in the vitreal chamber, ocular fundus clarity, presence of iris congestion, lens involvement, corneal clarity, conjunctival congestion and conjunctival swelling. In this process, the rabbit is evaluated prior to injection of the viscoelastic agent or solution and 48 hours post injection. Each parameter is evaluated on a scale of 0 to 5. A non-inflammatory sample consists of a mean total score of equal to or less than one or a vitreal cell count less than 50 cells/mm.sup.3. This is an extremely sensitive system for detecting small amounts of inflammatory agents in viscoelastic agents or solutions. The test solution is rated as acceptable for veterinary or human use if a non-inflammatory response is obtained in this process.
摘要翻译:这是非灵长类玻璃体替代过程,其定量为粘弹剂或溶液的炎症反应。 更具体地,兔子玻璃体替代过程包括用粘弹性剂或溶液手术置换少量兔中心凝胶玻璃体,并在48小时后测量玻璃体和前房中白细胞的侵入 注射。 测量的附加参数是玻璃体腔中的前房耀斑,浑浊和耀斑,眼底清晰度,虹膜充血的存在,镜片参与,角膜清晰度,结膜充血和结膜肿胀。 在该过程中,在注射粘弹剂或溶液之前和注射后48小时评价兔子。 每个参数以0至5的等级进行评估。非炎性样品由等于或小于1的平均总分数或小于50个细胞/ mm 3的玻璃体细胞计数组成。 这是一种非常敏感的系统,用于在粘弹剂或溶液中检测少量的炎症因子。 如果在该过程中获得非炎症反应,则测试溶液被评为兽医或人类可接受的。
摘要:
Intracorneal or epicorneal lens with a plurality of fixation holes spaced about the outer circumference of the lens. The lens can be of a soft material, such as hydrogel, a high refractive index material such as polysulfone, polycarbonate, or polyethylene, or any other material. The lens can also be coated with any suitable material, such as hydrogel or glycosaminoglycan.
摘要:
An intracorneal lens with at least one hole such as central pinhole, or a, plurality of pinholes or the like; and, a material filling the holes or a material filling the pinholes, and coating the lens. The intracorneal lens can be of any high index of refraction material. The material filling the holes as well as coating the lens can be a gas permeable polymer or metabolite permeable material, a biocompatible polymer or biocompatible material, or a neutral or negatively charged material.
摘要:
A synthetic epicorneal lens for use in the treatment of refractive errors. The lens is of a plastic that is compatible with the cornea, may be gas permeable or metabolite permeable, and may be coated with a basement membrane material such as fibronectin or laminen. The lens can be made from polymers, hydrogel, silicone, fluoropolymer, cellulose acetate butyrate, or other like material.