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37 条记录 (耗时 0.023 秒)

    Process for the preparation of phenylethanolaminotetralins
    34.
    发明授权
    Process for the preparation of phenylethanolaminotetralins 失效
    制备苯乙醇氨基三苯乙烯的方法

    公开(公告)号：US5235103A

    公开(公告)日：1993-08-10

    申请号：US990762

    申请日：1992-12-15

    申请人： Robert Boigegrain ,  Roberto Cecchi ,  Sergio Boveri

    发明人： Robert Boigegrain ,  Roberto Cecchi ,  Sergio Boveri

    IPC分类号： C07C233/12

    CPC分类号： C07C233/12

    摘要： A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and R.sup.o is hydrogen or a methyl group substituted by a carboxy or a lower carbalkoxy group, which comprises treating a mandelic acid with a 2-amino-7-hydroxytetralin, optionally alkylating with a lower alkyl haloacetate and reducing the amido group of the mandelamide into a methyleneamino group. The mandelamides intermediates are novel.

    摘要翻译： 一种制备式IMAMA的苯基乙醇氨基十氢化萘的方法，其中X是氢，卤素，三氟甲基或低级烷基，Ro是氢或被羧基或低级烷氧基取代的甲基，其包括处理扁桃酸 酸与2-氨基-7-羟基四氢萘，任选地与卤代低级烷基酯烷基化，并将扁桃酰胺的酰胺基还原成亚甲基氨基。 扁桃酰胺中间体是新颖的。

    Process for the preparation of phenylethanolaminotetralins
    35.
    发明授权
    Process for the preparation of phenylethanolaminotetralins 失效
    制备苯乙醇氨基三苯乙烯的方法

    公开(公告)号：US5198586A

    公开(公告)日：1993-03-30

    申请号：US603247

    申请日：1990-10-25

    申请人： Robert Boigegrain ,  Roberto Cecchi ,  Sergio Boveri

    发明人： Robert Boigegrain ,  Roberto Cecchi ,  Sergio Boveri

    IPC分类号： C07C233/12

    CPC分类号： C07C233/12

    摘要： A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and R.degree. is hydrogen or a methyl group substituted by a carboxy or a lower carbalkoxy group, which comprises treating a mandelic acid with a 2-amino-7-hydroxytetralin, optionally alkylating with a lower alkyl haloacetate and reducing the amido group of the mandelamide into a methyleneamino group. The mandelamides intermediates are novel.

    摘要翻译： 一种制备式IMAMA的苯乙醇氨基十氢化萘的方法，其中X为氢，卤素，三氟甲基或低级烷基，R为氢或被羧基或低级烷氧基取代的甲基，其包括处理 扁桃酸与2-氨基-7-羟基四氢萘基，任选地与卤代低级烷基酯烷基化并将扁桃酰胺的酰胺基还原成亚甲基氨基。 扁桃酰胺中间体是新颖的。

    Use of 5-alkylpyridazine derivatives as drugs active on the cholinergic system
    36.
    发明授权
    Use of 5-alkylpyridazine derivatives as drugs active on the cholinergic system 失效
    作为药物活性成分的5-烷基吡啶衍生物的使用

    公开(公告)号：US5081119A

    公开(公告)日：1992-01-14

    申请号：US475490

    申请日：1990-02-07

    申请人： Robert Boigegrain ,  Camille G. Wermuth ,  Paul Worms

    发明人： Robert Boigegrain ,  Camille G. Wermuth ,  Paul Worms

    IPC分类号： A61K31/50 ,  A61K31/535 ,  A61P25/28 ,  C07D237/20

    CPC分类号： A61K31/50 ,  A61K31/535 ,  C07D237/20

    摘要： The invention relates to the use of 5-alkylpyridazine derivatives of the formula ##STR1## in which R.sub.1 is a C.sub.1 -C.sub.4 alkyl group or a phenyl group and R.sub.2 and R.sub.3 independently are a C.sub.1 -C.sub.4 alkyl group, or R.sub.2 and R.sub.3, taken with the nitrogen atom to which they are bonded, form a morpholino group, or one of their pharmaceutically acceptable salts, for the preparation of pharmaceutical compositions for combating pathological conditions associated with a cortical cholinergic deficiency, especially for the treatment of degenerative syndromes associated with senescence.

    摘要翻译： 本发明涉及式（Ⅱ）的5-烷基哒嗪衍生物，其中R 1是C 1 -C 4烷基或苯基，R 2和R 3独立地是C 1 -C 4烷基，或R 2和 R3与其键合的氮原子一起形成吗啉基或其药学上可接受的盐之一，用于制备用于对抗与皮层胆碱能缺乏相关的病理状况的药物组合物，特别是用于治疗退行性综合征 与衰老有关。