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37 条记录 (耗时 0.024 秒)

    Use of 5-alkylpyridazine derivatives as drugs active on the cholinergic system
    1.
    发明授权
    Use of 5-alkylpyridazine derivatives as drugs active on the cholinergic system 失效
    作为药物活性成分的5-烷基吡啶衍生物的使用

    公开(公告)号：US5081119A

    公开(公告)日：1992-01-14

    申请号：US475490

    申请日：1990-02-07

    申请人： Robert Boigegrain ,  Camille G. Wermuth ,  Paul Worms

    发明人： Robert Boigegrain ,  Camille G. Wermuth ,  Paul Worms

    IPC分类号： A61K31/50 ,  A61K31/535 ,  A61P25/28 ,  C07D237/20

    CPC分类号： A61K31/50 ,  A61K31/535 ,  C07D237/20

    摘要： The invention relates to the use of 5-alkylpyridazine derivatives of the formula ##STR1## in which R.sub.1 is a C.sub.1 -C.sub.4 alkyl group or a phenyl group and R.sub.2 and R.sub.3 independently are a C.sub.1 -C.sub.4 alkyl group, or R.sub.2 and R.sub.3, taken with the nitrogen atom to which they are bonded, form a morpholino group, or one of their pharmaceutically acceptable salts, for the preparation of pharmaceutical compositions for combating pathological conditions associated with a cortical cholinergic deficiency, especially for the treatment of degenerative syndromes associated with senescence.

    摘要翻译： 本发明涉及式（Ⅱ）的5-烷基哒嗪衍生物，其中R 1是C 1 -C 4烷基或苯基，R 2和R 3独立地是C 1 -C 4烷基，或R 2和 R3与其键合的氮原子一起形成吗啉基或其药学上可接受的盐之一，用于制备用于对抗与皮层胆碱能缺乏相关的病理状况的药物组合物，特别是用于治疗退行性综合征 与衰老有关。

    2-amino-7-hydroxytetraline ethers
    8.
    发明授权
    2-amino-7-hydroxytetraline ethers 失效
    2-氨基-7-羟基四氢化萘

    公开(公告)号：US5202466A

    公开(公告)日：1993-04-13

    申请号：US922486

    申请日：1992-07-31

    申请人： Robert Boigegrain ,  Roberto Cecchi ,  Sergio Boveri

    发明人： Robert Boigegrain ,  Roberto Cecchi ,  Sergio Boveri

    IPC分类号： C07C229/00

    CPC分类号： C07C229/00

    摘要： 2-amino-7-hydroxytetraline ethers of formula ##STR1## wherein R' represents methyl substituted by a carboxy group or lower carbalkoxy group or a salt thereof; a process for their preparation starting from the 2-amino-7-hydroxytetraline, N-protection, O-alkylation and N-deprotection; N-protected intermediates; and use of the compounds I for the preparation of the corresponding phenylethanolaminotetralines.

    摘要翻译： 其中R'表示被羧基或低级烷氧羰基取代的甲基或其盐的2-氨基-7-羟基四氢化萘， 从2-氨基-7-羟基四氢化萘，N-保护，O-烷基化和N-去保护开始制备其制备方法。 N-保护的中间体; 以及使用化合物I制备相应的苯基乙醇胺三酰四氢呋喃。

    Carboxamidothiazole derivatives, preparation, pharmaceutical compositions containing them
    10.
    发明授权
    Carboxamidothiazole derivatives, preparation, pharmaceutical compositions containing them 失效
    载体酰胺噻唑衍生物，制剂，含有它们的药物组合物

    公开(公告)号：US06380230B1

    公开(公告)日：2002-04-30

    申请号：US09508830

    申请日：2000-06-02

    申请人： Roger Brodin ,  Robert Boigegrain ,  Eric Bignon ,  Jean Charles Molimard ,  Dominique Olliero

    发明人： Roger Brodin ,  Robert Boigegrain ,  Eric Bignon ,  Jean Charles Molimard ,  Dominique Olliero

    IPC分类号： C07D41712

    CPC分类号： C07D471/04 ,  C07D417/12 ,  C07D417/14

    摘要： The present invention relates to cholecystokinin (CCK)-agonist substituted thiazoles of formula: in which R1 is a substituted phenyl group, R2 is a group chosen from CH2—R7, (CH2)2—R7, S—CH2—R7, CH2—S—R7 and (C5-C8)alkyl with R7 being a (C5-C7)cycloalkyl group, and R3 is a group with R8 being a group (CH2)nR15 or and R15 being COOH or COO(C1-C4)alkyl. The invention also relates to a process for the preparation of the pharmaceutical compositions containing them and to their uses for the preparation of medicines.

    摘要翻译： 本发明涉及下列通式的缩胆囊素（CCK） - 拮抗剂取代的噻唑：其中R1是取代的苯基，R2是选自CH2-R7，（CH2）2-R7，S-CH2-R7，CH2- S-R7和（C5-C8）烷基，其中R7是（C5-C7）环烷基，R3是具有R8（CH 2）nR15的基团，R15是COOH或COO（C1-C4）烷基）。 本发明还涉及制备含有它们的药物组合物及其用于制备药物的用途的方法。