公开(公告)号：US07998137B2

公开(公告)日：2011-08-16

申请号：US12758686

申请日：2010-04-12

申请人： Lisa Elkins ,  Ronald Williams

发明人： Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B18/14 ,  A61B2017/00747 ,  A61B2017/00792 ,  A61B2018/00023 ,  A61B2018/00041 ,  A61B2018/00452 ,  A61B2018/00464 ,  A61B2018/0262 ,  A61B2018/0293 ,  A61M5/44 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003

摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

公开(公告)号：US07862558B2

公开(公告)日：2011-01-04

申请号：US12399598

申请日：2009-03-06

申请人： Lisa Elkins ,  Ronald Williams

发明人： Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B18/14 ,  A61B2017/00747 ,  A61B2018/00041 ,  A61B2018/0262 ,  A61B2018/0293

摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

摘要翻译： 装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。 冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。 冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。 相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。 一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。

公开(公告)号：US20100198207A1

公开(公告)日：2010-08-05

申请号：US12758686

申请日：2010-04-12

申请人： Lisa Elkins ,  Ronald Williams

发明人： Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B18/14 ,  A61B2017/00747 ,  A61B2017/00792 ,  A61B2018/00023 ,  A61B2018/00041 ,  A61B2018/00452 ,  A61B2018/00464 ,  A61B2018/0262 ,  A61B2018/0293 ,  A61M5/44 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003

摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

摘要翻译： 装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。 冷却可改造一个或多个靶组织，以便实现目标组织的组成中所需的变化和/或其行为的改变。 冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。 相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。 一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。

公开(公告)号：US07713266B2

公开(公告)日：2010-05-11

申请号：US11295204

申请日：2005-12-05

申请人： Lisa Elkins ,  Ronald Williams

发明人： Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B18/14 ,  A61B2017/00747 ,  A61B2017/00792 ,  A61B2018/00023 ,  A61B2018/00041 ,  A61B2018/00452 ,  A61B2018/00464 ,  A61B2018/0262 ,  A61B2018/0293 ,  A61M5/44 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003

摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

摘要翻译： 装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。 冷却可改造一个或多个靶组织，以便实现目标组织的组成中所需的变化和/或其行为的改变。 冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。 相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。 一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。

公开(公告)号：USD607919S1

公开(公告)日：2010-01-12

申请号：US29336725

申请日：2009-05-07

申请人： Ronald Williams

设计人： Ronald Williams

CPC分类号： G02C3/003

公开(公告)号：US20090171334A1

公开(公告)日：2009-07-02

申请号：US12399598

申请日：2009-03-06

申请人： Lisa Elkins ,  Ronald Williams

发明人： Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B18/14 ,  A61B2017/00747 ,  A61B2018/00041 ,  A61B2018/0262 ,  A61B2018/0293

摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

摘要翻译： 装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。 冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。 冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。 相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。 一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。

公开(公告)号：US20080154254A1

公开(公告)日：2008-06-26

申请号：US11614887

申请日：2006-12-21

申请人： Keith Burger ,  Ronald Williams ,  Lisa Elkins

发明人： Keith Burger ,  Ronald Williams ,  Lisa Elkins

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/00747 ,  A61B2018/00452 ,  A61B2018/0262 ,  A61B2018/0293

摘要： Medical devices, systems, and methods optionally treat dermatological and/or cosmetic defects, and/or a wide range of additional target tissues. Embodiments apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. Treatment may be applied along most or all of the insertable length of an elongate needle, optionally by introducing cryogenic cooling fluid into the needle lumen through a small, tightly-toleranced lumen of a fused silica fluid supply tube, with the supply tube lumen often metering the cooling fluid. Treatment temperature and/or time control may be enhanced using a simple pressure relief valve coupled to the needle lumen via a limited total exhaust volume space.

摘要翻译： 医疗装置，系统和方法可任选地治疗皮肤病和/或美容缺陷，和/或广泛的其它靶组织。 实施例用至少一个小的组织穿透探针进行冷却，所述探针通常包括具有适合于穿过患者皮肤的暴露表面插入的尺寸的针而不留下可见的瘢痕。 治疗可以沿着细长针的大部分或全部可插入长度施加，任选地通过将低温冷却流体通过熔融二氧化硅流体供应管的小的，紧密公差的管腔引入针内腔，供应管内腔经常计量 冷却液。 可以通过经由有限的总排气量空间耦合到针内腔的简单的压力释放阀来增强治疗温度和/或时间控制。

公开(公告)号：US20070143604A1

公开(公告)日：2007-06-21

申请号：US11304853

申请日：2005-12-15

申请人： Diana Arroyo ,  George Blakley ,  Damir Jamsek ,  Sridhar Muppidi ,  Kimberly Simon ,  Ronald Williams

发明人： Diana Arroyo ,  George Blakley ,  Damir Jamsek ,  Sridhar Muppidi ,  Kimberly Simon ,  Ronald Williams

IPC分类号： H04L9/00

CPC分类号： G06F21/6218

摘要： A reference monitor system, apparatus, computer program product and method are provided. In one illustrative embodiment, elements of the data processing system are associated with security data structures in a reference monitor. An information flow request is received from a first element to authorize an information flow from the first element to a second element. A first security data structure associated with the first element and a second security data structure associated with the second element are retrieved. At least one set theory operation is then performed on the first security data structure and the second security data structure to determine if the information flow from the first element to the second element is to be authorized. The security data structures may be labelsets having one or more labels identifying security policies to be applied to information flows involving the associated element.

摘要翻译： 提供了参考监视器系统，装置，计算机程序产品和方法。 在一个说明性实施例中，数据处理系统的元件与参考监视器中的安全数据结构相关联。 从第一元素接收信息流请求，以授权从第一元素到第二元素的信息流。 检索与第一元素相关联的第一安全数据结构和与第二元素相关联的第二安全数据结构。 然后对第一安全数据结构和第二安全数据结构执行至少一组理论操作，以确定是否授权从第一元素到第二元素的信息流。 安全数据结构可以是具有标识要应用于涉及相关元素的信息流的安全策略的一个或多个标签的标签集。

公开(公告)号：US20070080508A1

公开(公告)日：2007-04-12

申请号：US11609204

申请日：2006-12-11

申请人： Kevin Owens ,  Scott Chapman ,  Ronald Williams ,  Perry Stow

发明人： Kevin Owens ,  Scott Chapman ,  Ronald Williams ,  Perry Stow

IPC分类号： B62B15/00

CPC分类号： B62D63/061 ,  B62D63/062

摘要： A cargo trailer having a frame assembly with pivotally mounted wall structures or frames. The frame assembly can be collapsed into a compact shipping configuration wherein the wall structures are positioned substantially parallel with the floor structure of the trailer. Various parts of the cargo trailer can also be stowed in the collapsed frame assembly for shipment of the frame assembly and stored parts. After shipment of the cargo trailer, the wall structures are pivoted into their upright positions and the final assembly of the cargo trailer is completed. Exterior panels may be shipped together in a compact stack with the frame to the final assembly location where the panels are attached to the cargo trailer.

摘要翻译： 货物拖车，具有带枢转安装的墙壁结构或框架的框架组件。 框架组件可以折叠成紧凑的运输配置，其中壁结构基本上平行于拖车的底板结构定位。 货物拖车的各种部件也可以收纳在折叠的框架组件中，用于运输框架组件和存储的部件。 在装运货物拖车后，墙壁结构枢转到其直立位置，货物拖车的最终组装完成。 外部面板可以以紧凑的堆叠方式一起运输到框架到最终组装位置，其中面板附接到货物拖车。

公开(公告)号：US20060212028A1

公开(公告)日：2006-09-21

申请号：US11252466

申请日：2005-10-17

申请人： James Joye ,  Richard Williams ,  Ronald Williams

发明人： James Joye ,  Richard Williams ,  Ronald Williams

IPC分类号： A61B18/02

CPC分类号： A61B18/0218 ,  A61B18/02 ,  A61B2017/00292 ,  A61B2017/22054 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Improved systems, devices, and methods for delivering cryogenic cooling fluid to cryosurgical probes such as cryosurgical endovascular balloon catheters take advantage of the transients during the initiation and termination of cryogenic fluid flow to moderate the treatment temperatures of tissues engaged by the probe. A flow limiting element along a cryogenic fluid path intermittently interrupts the flow of cooling fluid, often cycling both the fluid flow and treatment temperature. This can maintain the tissue treatment temperature within a predetermined range which is above the treatment temperature provided by a steady flow of cryogenic fluid. In another aspect, room temperature single-use cooling fluid cartridges are filled with a sufficient quantity of cryosurgical fluid to effect a desired endovascular cryosurgical treatment.