公开(公告)号：US20090004295A1

公开(公告)日：2009-01-01

申请号：US12132761

申请日：2008-06-04

申请人： Friedrich W. KUEHNE ,  Michael McGrath ,  Edgar Engleman

发明人： Friedrich W. KUEHNE ,  Michael McGrath ,  Edgar Engleman

IPC分类号： A61K33/20 ,  A61P11/06

CPC分类号： A61K33/40 ,  Y02A50/401

摘要： Methods of using a stabilized chlorite solution to inhibit antigen-specific immune responses are disclosed. The stabilized chlorite solution, when administered to a mammal in need thereof, can prevent the presentation of antigens by antigen presenting cells. The stabilized chlorite solution therefore is useful in treating, inter alia, auto-immune diseases, treating diseases caused by an inappropriate immune response, treating lymphoproliferative disease and in inhibiting rejection in transplant patients.

摘要翻译： 公开了使用稳定的亚氯酸盐溶液来抑制抗原特异性免疫应答的方法。 当向有需要的哺乳动物施用时，稳定的亚氯酸盐溶液可以防止抗原呈递细胞呈递抗原。 因此，稳定的亚氯酸盐溶液可用于治疗特别是自身免疫疾病，治疗由不适当的免疫应答引起的疾病，治疗淋巴增生性疾病和抑制移植患者的排斥反应。

公开(公告)号：US07198946B2

公开(公告)日：2007-04-03

申请号：US10299946

申请日：2002-11-18

申请人： Laurence J. Marton ,  Tennore M. Ramesh ,  Sean Scott ,  Michael McGrath

发明人： Laurence J. Marton ,  Tennore M. Ramesh ,  Sean Scott ,  Michael McGrath

IPC分类号： C12N5/08 ,  G01N33/53 ,  C12Q1/02

CPC分类号： A61K31/00 ,  A61K31/13 ,  A61K31/135 ,  A61K31/198 ,  G01N33/56972 ,  G01N33/6893 ,  G01N2333/70535 ,  G01N2333/70596 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2800/28

摘要： The invention provides methods of monitoring amyotrophic lateral sclerosis (ALS) disease development or progression and monitoring an ALS therapy by determining the level of HLA-DR expression by CD14+ monocytes and/or the percentage of CD16+ cells in the population of CD14+ cells and/or the number of CD14+/CD16+ cells in peripheral blood of an individual with ALS. The invention is also directed to methods for decreasing the number of circulating CD14+ monocytes and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual with ALS. The invention is also directed to methods of screening for agents which decrease the population of CD14+ monocytes with elevated HLA-DR expression and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual with ALS.

摘要翻译： 本发明提供了通过测定CD14 +单核细胞的HLA-DR表达水平和/或CD14 +细胞群体中CD16 +细胞的百分比和/或其它方法来监测肌萎缩性侧索硬化（ALS）疾病发展或进展并监测ALS治疗的方法。 ALS患者外周血CD14 + / CD16 +细胞数。 本发明还涉及用于减少患有ALS的个体中CD14 + / CD16 +细胞循环CD14 +和/或CD14 + / CD16 +细胞数量和/或CD14 + / CD16 +细胞数量的方法。 本发明还涉及筛选在具有ALS的个体中降低HLA-DR表达和/或CD14 + / CD16 +细胞群体和/或CD14 + / CD16 +细胞数目的CD14 +单核细胞群体的试剂的方法。

公开(公告)号：US20060159775A1

公开(公告)日：2006-07-20

申请号：US11378987

申请日：2006-03-17

申请人： Michael McGrath

发明人： Michael McGrath

IPC分类号： A61K33/14

CPC分类号： A61K33/20 ,  A61K9/0019 ,  A61K33/00 ,  A61K33/40 ,  A61K47/02 ,  Y10S514/879 ,  Y10S514/885

摘要： The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation. The invention also features methods of monitoring therapy by assessing blood immune cell activation before and after therapy.

摘要翻译： 本发明的特征在于通过施用有效降低血液免疫细胞活化的量的亚氯酸盐来治疗受试者中巨噬细胞相关神经变性疾病如肌萎缩性侧索硬化（ALS），阿尔茨海默病（AD）或多发性硬化症（MS）的方法。 本发明还具有通过评估治疗前后的免疫细胞活化来监测治疗的方法。

公开(公告)号：US20050221683A1

公开(公告)日：2005-10-06

申请号：US11086815

申请日：2005-03-22

申请人： Michael McGrath ,  Thomas Wong ,  Max Hibner

发明人： Michael McGrath ,  Thomas Wong ,  Max Hibner

IPC分类号： H01R13/502 ,  H02G3/04 ,  H04Q1/06 ,  H05K7/18

CPC分类号： H04Q1/062 ,  H02G3/0406 ,  H02G3/045 ,  H04Q2201/02 ,  H05K7/186

摘要： Cable managers of the present invention include a panel, at least two adjacent spaced-apart projections, which define an opening therebetween, and a tab connected to at least one of the projections. The tab assists in cable routing and retention. In one embodiment, the tab extends to a distance at least midway between a top surface of the one projection and the bottom surface of the other projection. In another embodiment, a distance between a top surface of the tab on one projection and the bottom surface of another adjacent projection is between about 0.10 inches and about 0.30 inches. In yet another embodiment, a cable manager comprises separable portions, and at least one spacer member which is adapted to be attached to each of separable first and second portions. The spacer member increases the width of the manager to provide additional space to run cable within the manager.

摘要翻译： 本发明的电缆管理器包括一个面板，至少两个相邻的间隔开的突起，其在它们之间限定一个开口，以及连接到至少一个凸起的凸片。 该选项卡有助于电缆布线和保留。 在一个实施例中，突片至少在一个突起的顶表面和另一个突起的底表面之间的中间至少中间延伸。 在另一个实施例中，一个突起上的突片的顶表面与另一相邻突起的底表面之间的距离在约0.10英寸至约0.30英寸之间。 在另一个实施例中，电缆管理器包括可分离部分，以及至少一个间隔件，其适于附接到每个可分离的第一和第二部分。 间隔件增加了管理器的宽度，以提供额外的空间以在管理器内运行电缆。

公开(公告)号：US5413240A

公开(公告)日：1995-05-09

申请号：US123426

申请日：1993-09-17

申请人： John Hunter ,  Charles Hudson ,  Michael McGrath

发明人： John Hunter ,  Charles Hudson ,  Michael McGrath

IPC分类号： B65D39/08 ,  B65D51/18

CPC分类号： B65D39/084

摘要： A drum closure system is provided for protecting the integrity of the threads of a drum neck and for providing the safe and easy installation of a replaceable closure neck. The drum closure system primarily comprises a drum with a drum neck integrally formed in the drum top, a closure plug, a replaceable closure neck which is interposed threadably between the drum neck and the closure plug, and a specialized tool for installing and removing the replaceable closure neck. The use of the tool, which is designed to enable exertion of very high levels of torque on the replaceable neck, eliminates the need for a locking mechanism between the replaceable neck and drum neck because insertion of the replaceable neck at a high torque measurement virtually eliminates the possibility of relative rotation of the replaceable neck without the specialized tool. Installation of the closure plug makes the removal of the replaceable neck virtually impossible.

摘要翻译： 提供鼓关闭系统以保护鼓颈的螺纹的完整性，并提供可更换的闭合颈部的安全和容易的安装。 滚筒封闭系统主要包括一个滚筒，鼓筒整体地形成在滚筒顶部，一个封闭塞子，一个可更换的封闭颈部，其可以螺纹地插入在滚筒颈部和封闭塞子之间，以及一个专门的工具，用于安装和拆卸可更换的 关闭颈部 设计用于在可更换的颈部上施加非常高水平的扭矩的工具的使用消除了在可更换的颈部和鼓颈部之间的锁定机构的需要，因为在高扭矩测量中插入可更换的颈部实际上消除了 没有专用工具可更换颈部的相对旋转的可能性。 封闭塞的安装使得可更换的颈部的移除实际上是不可能的。

公开(公告)号：US20210216039A1

公开(公告)日：2021-07-15

申请号：US17213982

申请日：2021-03-26

申请人： Jakub Wenus ,  Niall Cahill ,  Inbarasan Muniraj ,  Ashley Deflumere ,  Michael McGrath

发明人： Jakub Wenus ,  Niall Cahill ,  Inbarasan Muniraj ,  Ashley Deflumere ,  Michael McGrath

IPC分类号： G03H1/04 ,  G03H1/08 ,  G03H1/22 ,  G03H1/16 ,  G03H1/00

摘要： Digital holographic microscopy and related image processing techniques are described. A hologram captured in an image frame is split into different depths while a new hologram is being captured. Image slices of the hologram are determined and using free space impulse responses that are pre-calculated at a different precision than processing operations using the holographic data. Each computation is calculated in parallel based on the number of available processing cores and threads. The image slices are combined into a 2D array or 3D array to permit further processing of the combined array to count and size particles in the image frame. The reconstructed hologram is displayed at a subsequent image frame than that used to capture the hologram.

公开(公告)号：US08413261B2

公开(公告)日：2013-04-02

申请号：US12130867

申请日：2008-05-30

申请人： Yaakov M. Nemoy ,  Michael McGrath

发明人： Yaakov M. Nemoy ,  Michael McGrath

IPC分类号： H04L29/06

CPC分类号： H04L63/102 ,  G06F21/6254 ,  H04L63/0407

摘要： Sharing a secret that can later be revoked. A client sends data to a server that makes the data available to other clients. The data is shared generically without specifically identifying the client. The data can be considered quasi-secret data or data that is secret except for the anonymous sharing of the data. The client can later make the shared data private again by changing or deleting the sharing of the data.

摘要翻译： 分享一个可以被撤销的秘密。 客户端将数据发送到使数据可用于其他客户端的服务器。 数据是一般共享的，没有专门识别客户端。 数据可以被认为是秘密数据或除了匿名共享数据之外的秘密数据。 客户端可以稍后通过更改或删除数据共享来将共享数据重新设置为私有。

公开(公告)号：USD670156S1

公开(公告)日：2012-11-06

申请号：US29400541

申请日：2011-08-30

申请人： Richard C. Crooks ,  Garrett S. Lyons ,  Michael McGrath

设计人： Richard C. Crooks ,  Garrett S. Lyons ,  Michael McGrath

公开(公告)号：US08198334B2

公开(公告)日：2012-06-12

申请号：US11064781

申请日：2005-02-22

申请人： Michael McGrath

发明人： Michael McGrath

IPC分类号： A61K31/13 ,  A61K31/655

CPC分类号： A61K31/13 ,  A61K31/131 ,  A61K31/155 ,  G01N33/6896 ,  G01N2333/523 ,  G01N2800/164

摘要： Methods for modulating macrophage proliferation in an individual afflicted with or at risk for an ocular disease such as ARMD are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including ARMD. The invention also provides methods for aiding diagnosis and monitoring therapy of an ocular disease such as ARMD.

摘要翻译： 提供了在患有或具有眼部疾病如ARMD的风险的个体中调节巨噬细胞增殖的方法。 该方法采用多胺类似物，或其盐或被保护的衍生物。 巨噬细胞增殖已涉及许多严重的疾病，包括ARMD。 本发明还提供了用于帮助诊断和监测眼部疾病如ARMD的治疗的方法。

公开(公告)号：US20070293095A1

公开(公告)日：2007-12-20

申请号：US11850446

申请日：2007-09-05

申请人： Michael McGrath ,  Thomas Wong ,  Max Hibner

发明人： Michael McGrath ,  Thomas Wong ,  Max Hibner

IPC分类号： H01R13/502

CPC分类号： H04Q1/062 ,  H02G3/0406 ,  H02G3/045 ,  H04Q2201/02 ,  H05K7/186

摘要： Cable managers of the present invention include a panel, at least two adjacent spaced-apart projections, which define an opening therebetween, and a tab connected to at least one of the projections. The tab assists in cable routing and retention. In one embodiment, the tab extends to a distance at least midway between a top surface of the one projection and the bottom surface of the other projection. In another embodiment, a distance between a top surface of the tab on one projection and the bottom surface of another adjacent projection is between about 0.10 inches and about 0.30 inches. In yet another embodiment, a cable manager comprises separable portions, and at least one spacer member which is adapted to be attached to each of separable first and second portions. The spacer member increases the width of the manager to provide additional space to run cable within the manager.

摘要翻译： 本发明的电缆管理器包括一个面板，至少两个相邻的间隔开的突起，其在它们之间限定一个开口，以及连接到至少一个凸起的凸片。 该选项卡有助于电缆布线和保留。 在一个实施例中，突片至少在一个突起的顶表面和另一个突起的底表面之间的中间至少中间延伸。 在另一个实施例中，一个突起上的突片的顶表面与另一相邻突起的底表面之间的距离在约0.10英寸至约0.30英寸之间。 在另一个实施例中，电缆管理器包括可分离部分，以及至少一个间隔件，其适于附接到每个可分离的第一和第二部分。 间隔件增加了管理器的宽度，以提供额外的空间以在管理器内运行电缆。