公开(公告)号：US5270344A

公开(公告)日：1993-12-14

申请号：US840388

申请日：1992-02-24

申请人： Stephen Herman

发明人： Stephen Herman

IPC分类号： A61K31/00 ,  A61K31/335 ,  A61L2/00 ,  C07D323/02 ,  A61K31/07 ,  A01N31/04

CPC分类号： C07D323/02 ,  A61K31/335 ,  A61L2/0088

摘要： The present invention provides a method of medical treatment for systemic disorders and oral pharyngeal conditions in a mammal. In this method, a pharmacologically effective amount for treatment of the disorder or condition of a trioxolane or a diperoxide of an unsaturated hydrocarbon, such as a terpene or non-terpene, is applied to the mammal. The invention also provides pharmaceutical compositions for use in these methods.

摘要翻译： 本发明提供一种哺乳动物的系统性疾病和口咽病症的治疗方法。 在该方法中，对哺乳动物施用用于治疗不饱和烃（如萜烯或非萜烯）的三恶烷或二过氧化物的病症或状况的药理学有效量。 本发明还提供了用于这些方法的药物组合物。

公开(公告)号：US5190979A

公开(公告)日：1993-03-02

申请号：US896735

申请日：1992-06-09

申请人： Stephen Herman

发明人： Stephen Herman

IPC分类号： C07D323/02

CPC分类号： C07D323/02 ,  Y10S424/13 ,  Y10S514/858 ,  Y10S514/859 ,  Y10S514/86 ,  Y10S514/861 ,  Y10S514/862 ,  Y10S514/863 ,  Y10S514/864

摘要： Ozonides of terpenes are disclosed. Terpenes which are believed to be pharmacologically active when prepared in accordance with the present invention include: limonene, citronella, alpha-carotene, beta-carotene, Vitamin A, linalool, linalyl acetate, or squalene. Other compounds which are believed to make pharmacologically active terpene ozonides in accordance with the present invention include geraniol, limonene, alpha-pinene, loganin, cymene, farnesanes, eudesmanes, acoranes, cedranes, chamigranes, caryophyllanes, illudanes, humulenes, himachalenes, longifolanes, perhydroazulenes, quaianes, quaianolides, or germacranes. Still other compounds which are believed to make pharmacologically active terpene ozonides in accordance with the present invention include labdanes, clerodanes, abietic acid, phyllocladene, giberellins, ophiobolin A, retigeranic acid, gasgardic acid, lanosterol, euphol, oleanane, ursane, lupeol, hydroxyhopanone, lupanes, or hopanes. Other particular terpene compounds which are believed to make pharmacologically active terpene ozonides when prepared in accordance with the present invention include B-selinene, zingibene, camphene, sabinene, ocimene, myrcene, nerol, citral A, citral B, farnesol, bisabolene, phytol, and cecropia hormone. A method of producing the terpene ozonides is also disclosed. Further, pharmaceutical preparations using these compositions are disclosed. Methods of medical treatment using these pharmaceutical preparations are also disclosed.

摘要翻译： 公开了萜烯的臭氧化物。 被认为在根据本发明制备时具有药理活性的萜烯包括：柠檬烯，香茅，α-胡萝卜素，β-胡萝卜素，维生素A，芳樟醇，乙酸里哪酯或角鲨烯。 根据本发明被认为具有药理学活性的萜烯臭氧化物的其它化合物包括香叶醇，柠檬烯，α-蒎烯，loganin，伞花烃，法呢那烯，甜食，仙人掌，仙人掌，chamigranes，叶绿素，illudanes，humulenes，himachalene，longifolanes， 全氢薁，夸族，quaianolides或锗。 根据本发明据信使制备药理学活性萜烯臭氧化物的其它化合物包括实验丹体，氯化丹宁，松香酸，叶绿素，赤霉素，奥昔布林A，retigeranic酸，gasgardic acid，羊毛甾醇，euphol，oleanane，ursane，lupeol，hydroxyhopanone ，兰帕斯，或丁烷。 当根据本发明制备时，被认为具有药理学活性的萜烯氧化物的其它特定的萜烯化合物包括B-蒎烯，吖辛烯，camp烯，桧烯，oc烯，月桂烯，橙花醇，柠檬醛A，柠檬醛B，法呢醇，双酚A， 和刺激性激素。 还公开了生产萜烯臭氧化物的方法。 此外，公开了使用这些组合物的药物制剂。 还公开了使用这些药物制剂的药物治疗方法。

公开(公告)号：US5190977A

公开(公告)日：1993-03-02

申请号：US795513

申请日：1991-11-21

申请人： Stephen Herman

发明人： Stephen Herman

IPC分类号： A61K31/00 ,  A61K31/335 ,  A61K36/886 ,  A61L2/00 ,  C07D323/02

CPC分类号： A61K36/886 ,  A61K31/335 ,  A61L2/0088 ,  C07D323/02

摘要： Methods of treating systemic viral infections are disclosed comprising the parenteral administration of pharmacologically effective amounts of ozonides of terpenes in pharmaceutically acceptable carriers. Methods for treating viral lesions are also disclosed. In particular, a method for treating retroviral infections is disclosed. More particularly, a method for treating HIV infections is disclosed. In addition, methods for treating infections of non-retroviral viruses are disclosed. Further, methods for treating T-cell deficiencies are also disclosed. Moreover, a method of producing blood for medical products which is free of viral activity is disclosed.

摘要翻译： 公开了治疗全身性病毒感染的方法，其包括在药学上可接受的载体中胃肠外施用药理学有效量的萜烯的臭氧化物。 还公开了治疗病毒病变的方法。 特别地，公开了一种治疗逆转录病毒感染的方法。 更具体地，公开了一种治疗HIV感染的方法。 此外，公开了用于治疗非逆转录病毒病毒感染的方法。 此外，还公开了治疗T细胞缺陷的方法。 此外，公开了一种不含病毒活性的医药用血液的制造方法。

公开(公告)号：US5093326A

公开(公告)日：1992-03-03

申请号：US369678

申请日：1989-06-19

申请人： Stephen Herman

发明人： Stephen Herman

IPC分类号： A01N31/02 ,  A01N43/26 ,  A01N45/00 ,  B27K3/34 ,  B27K3/36

CPC分类号： A01N43/26 ,  Y10S514/918 ,  Y10S514/919

摘要： Insecticidal and repellent compositions comprising ozonides of hydrocarbons are disclosed. Hydrocarbons which are believed to be active when prepared in accordance with the present invention include terpenes and unsaturated fatty acids derived from plant and animal sources. Other examples of suitable unsaturated hydrocarbons include natural and synthetic steroids, alkenes and their substituted derivatives, and other naturally or synthetically unsaturated hydrocarbons derived primarily from petroleum. Methods of use for the compositions are also disclosed.

摘要翻译： 公开了包含烃的臭氧化物的杀虫剂和驱虫剂组合物。 被认为在根据本发明制备时具有活性的烃包括衍生自植物和动物来源的萜烯和不饱和脂肪酸。 合适的不饱和烃的其它实例包括天然和合成的类固醇，烯烃及其取代的衍生物，以及主要衍生自石油的其它天然或合成不饱和烃。 还公开了组合物的使用方法。

公开(公告)号：US4983637A

公开(公告)日：1991-01-08

申请号：US363628

申请日：1989-06-08

申请人： Stephen Herman

发明人： Stephen Herman

IPC分类号： A61K31/335 ,  A61K31/357 ,  A61K36/185 ,  A61K36/48 ,  A61L2/00 ,  A61P31/12 ,  C07D307/00 ,  C07D317/00 ,  C07D321/00 ,  C07D323/02

CPC分类号： A61L2/0088 ,  A61K31/335 ,  A61K36/185 ,  A61K36/48 ,  C07D323/02

摘要： Methods of treating systemic viral infections are disclosed comprising the parenteral administration of pharmacologically effective amounts of ozonides of terpenes in pharmaceutically acceptable carriers. Methods for treating viral lesions are also disclosed. In particular, a method for treating rfetroviral infections is disclosed. More particularly, a method for treating HIV infections is disclosed. In addition, methods for treating infections of non-retroviral viruses are disclosed. Further, methods for trating T-cell deficiencies are also disclosed. Moreover, a method of producing blood for medical products which is free of viral activity is disclosed.

摘要翻译： 公开了治疗全身性病毒感染的方法，其包括在药学上可接受的载体中胃肠外施用药理学有效量的萜烯的臭氧化物。 还公开了治疗病毒病变的方法。 特别地，公开了治疗感染病毒的方法。 更具体地，公开了一种治疗HIV感染的方法。 此外，公开了用于治疗非逆转录病毒病毒感染的方法。 此外，还公开了用于培养T细胞缺陷的方法。 此外，公开了一种不含病毒活性的医药用血液的制造方法。

公开(公告)号：US4907367A

公开(公告)日：1990-03-13

申请号：US315399

申请日：1989-02-23

申请人： Stephen Herman

发明人： Stephen Herman

IPC分类号： A01M3/02

CPC分类号： A01M3/02

摘要： An insect swatter having flexible, parallel, non-overlapping, substantially contiguous tines allowing swatting of insects on regular or irregular surfaces, said tines being arranged to provide a substantially planar surface for striking insects by minimizing the force applied thereto so as to reduce lateral expulsion of insect bodily fluids.

摘要翻译： 具有柔性的，平行的，不重叠的，基本上邻接的齿的昆虫扫描器，其允许昆虫在规则或不规则表面上进行切割，所述尖齿布置成提供基本上平坦的表面，用于通过最小化施加到其上的力来击打昆虫，以便减少横向排出 的昆虫体液。