公开(公告)号：US08822194B2

公开(公告)日：2014-09-02

申请号：US11631247

申请日：2005-06-29

申请人： Ming Zhao ,  Meng Yang

发明人： Ming Zhao ,  Meng Yang

IPC分类号： C12N1/21 ,  A61K38/20 ,  A61K35/74 ,  A61K38/51

CPC分类号： A61K35/74 ,  A61K38/2013 ,  A61K38/51

摘要： Bacteria that are auxotrophic for at least two amino acids found in at least one tumor are effective anti tumor treatments, labeling agents, and vaccines against infection. Improved antitumor effects can also be provided such strains by passage through an appropriate tumor model.

摘要翻译： 在至少一种肿瘤中发现的至少两种氨基酸营养缺陷型细菌是有效的抗肿瘤治疗，标记试剂和针对感染的疫苗。 也可以通过适当的肿瘤模型通过这些菌株提供改善的抗肿瘤作用。

公开(公告)号：US08792732B1

公开(公告)日：2014-07-29

申请号：US13559420

申请日：2012-07-26

申请人： Ming Zhao ,  Jay Yagnik

发明人： Ming Zhao ,  Jay Yagnik

IPC分类号： G06K9/46 ,  H04N5/14

CPC分类号： G06K9/6232 ,  G06K9/6215

摘要： An object recognition system performs a number of rounds of dimensionality reduction and consistency learning on visual content items such as videos and still images, resulting in a set of feature vectors that accurately predict the presence of a visual object represented by a given object name within an visual content item. The feature vectors are stored in association with the object name which they represent and with an indication of the number of rounds of dimensionality reduction and consistency learning that produced them. The feature vectors and the indication can be used for various purposes, such as quickly determining a visual content item containing a visual representation of a given object name.

摘要翻译： 对象识别系统对诸如视频和静止图像的视觉内容项目执行多次维数降低和一致性学习，导致一组特征向量，其精确地预测由一个对象名称表示的视觉对象的存在 视觉内容项目。 特征向量与它们所代表的对象名称相关联地存储，并且显示产生它们的维度降低和一致性学习的轮次数。 特征向量和指示可以用于各种目的，诸如快速确定包含给定对象名称的视觉表示的视觉内容项。

公开(公告)号：US08778303B2

公开(公告)日：2014-07-15

申请号：US12987703

申请日：2011-01-10

申请人： Ming Zhao

发明人： Ming Zhao

IPC分类号： A61K51/00 ,  A61M36/14 ,  A61K38/03 ,  A61K38/04 ,  A61K38/10

CPC分类号： A61K38/03 ,  A61K38/04 ,  A61K38/10 ,  A61K51/088

摘要： The invention encompasses radiopharmaceutical compounds that can be used in imaging cell death associated with either apoptosis or necrosis. Phosphatidylethanolamine (PtdE) is externalized to the surface of apoptotic cells, and also becomes accessible in necrotic cells due to compromised plasma membrane integrity. Duramycin, a 19 amino acid polypeptide, binds PtdE at a 1:1 ratio with high affinity and exclusive specificity. Novel Duramycin-based radiopharmaceuticals and non-radioactively labeled compounds are disclosed herein. Such compounds facilitate detection of cell apoptosis and/or necrosis by binding to PtdE. The location of the bound compound can then be pinpointed using standard imaging techniques.

摘要翻译： 本发明包括可用于成像与细胞凋亡或坏死相关的细胞死亡的放射性药物化合物。 磷脂酰乙醇胺（PtdE）被外化于凋亡细胞的表面，并且由于损害的质膜完整性也在坏死细胞中变得易于接近。 19号氨基酸多肽耐久霉素以高亲和力和独特的特异性以1:1的比例结合PtdE。 本文公开了新的基于耐久霉素的放射性药物和非放射性标记的化合物。 这些化合物有助于通过结合PtdE来检测细胞凋亡和/或坏死。 然后可以使用标准成像技术精确定位结合化合物的位置。

公开(公告)号：US08581931B2

公开(公告)日：2013-11-12

申请号：US12790428

申请日：2010-05-28

申请人： Rakesh Kumar Arora ,  Keith William Paterson ,  Ming Zhao ,  Hong Albert Cai Wang ,  Dan Mihai Dumitru

发明人： Rakesh Kumar Arora ,  Keith William Paterson ,  Ming Zhao ,  Hong Albert Cai Wang ,  Dan Mihai Dumitru

IPC分类号： G09G5/00

CPC分类号： H04M1/72533 ,  G03B21/006 ,  G03B21/34 ,  H04M1/0272

摘要： A system and method are set forth for remotely controlling a presentation from a portable electronic device so as to freeze a slide on a remote projector to permit searching for a desired slide on the portable electronic device and then continuing the presentation when searching is complete. In one embodiment, a switch is provided in a communication layer of a presentation application such that when the switch is turned off, communication is suspended between the portable electronic device and the projector, thereby permitting browsing on the portable electronic device without interrupting the presentation. When the switch is turned on the current slide information is transmitted from the portable electronic device to the projector.

摘要翻译： 提出了一种用于远程控制来自便携式电子设备的演示的系统和方法，以便冻结远程投影仪上的幻灯片以允许在便携式电子设备上搜索期望的幻灯片，然后在搜索完成时继续呈现。 在一个实施例中，在演示应用的通信层中提供开关，使得当开关断开时，在便携式电子设备和投影仪之间暂停通信，从而允许在便携式电子设备上浏览而不中断演示。 当开关打开时，当前的幻灯片信息从便携式电子设备发送到投影仪。

公开(公告)号：US08301498B1

公开(公告)日：2012-10-30

申请号：US13488126

申请日：2012-06-04

申请人： Corinna Cortes ,  Sanjiv Kumar ,  Ameesh Makadia ,  Gideon Mann ,  Jay Yagnik ,  Ming Zhao

发明人： Corinna Cortes ,  Sanjiv Kumar ,  Ameesh Makadia ,  Gideon Mann ,  Jay Yagnik ,  Ming Zhao

IPC分类号： G06Q30/00 ,  G06N5/02

CPC分类号： H04N21/2407 ,  G06F17/30784 ,  G06F17/30817 ,  G06F17/3082 ,  G06F17/30828 ,  G06K9/00711 ,  H04N21/23418 ,  H04N21/25883 ,  H04N21/4668 ,  H04N21/4826

摘要： A video demographics analysis system selects a training set of videos to use to correlate viewer demographics and video content data. The video demographics analysis system extracts demographic data from viewer profiles related to videos in the training set and creates a set of demographic distributions, and also extracts video data from videos in the training set. The video demographics analysis system correlates the viewer demographics with the video data of videos viewed by that viewer. Using the prediction model produced by the machine learning process, a new video about which there is no a priori knowledge can be associated with a predicted demographic distribution specifying probabilities of the video appealing to different types of people within a given demographic category, such as people of different ages within an age demographic category.

摘要翻译： 视频人口统计分析系统选择用于将观众人口特征和视频内容数据相关联的一组视频。 视频人口统计分析系统从与训练集中的视频相关的观众简档中提取人口统计学数据，并创建一组人口分布，并从训练集中的视频中提取视频数据。 视频人口统计分析系统将观众人口统计学与观众观看的视频的视频数据相关联。 使用机器学习过程产生的预测模型，可以将预测的人口分布与预测的人口分布相关联，所述预测人口统计分布规定了给定人口统计学类别中的不同类型的人的视频的概率，例如人 在不同年龄的人口统计学类别。

公开(公告)号：US08227086B2

公开(公告)日：2012-07-24

申请号：US12438863

申请日：2007-08-23

申请人： Ming Zhao ,  John Fang

发明人： Ming Zhao ,  John Fang

IPC分类号： B32B9/04

CPC分类号： C08F220/18 ,  B01D19/0409 ,  C08F230/08 ,  C08L2203/14 ,  C09D7/47 ,  Y10T428/2891 ,  Y10T428/31663

摘要： Polymers are described that are prepared from di and mono-functional silicone and silane monomers of Formula 1 in which Y represents a direct bond or a oxy group; R1 represents an optionally substituted organo group with at least one double bond which optionally may be an activated unsaturated moiety such as a (meth)acrylate group: for example 1-n-propoxy(acrylate) or ethenyl; and R2 and R3 each separately, and independently within each optional repeat unit, represent an optionally substituted hydrocarbo, hydrocarbo(oxy), hydrosilico and/or hydrosilico(oxy) groups; or example, methyl; or trimethylsiloxy; R4 independently represents an optionally substituted organo group with at least one double bond (such as R1 above) an optionally substituted hydrocarbo, and/or hydrosilico group for example trimethylsilyl or ethenyl; and n is from about 0 to about 2000; preferably from about 1 to about 100, for example n is 1. Such polymer precursors can be used to prepare flow modifying agents, defoamers and/or pressure sensitive adhesives.

摘要翻译： 描述了由其中Y表示直接键或氧基的式1的二官能和单官能硅氧烷和硅烷单体制备的聚合物; R1表示任选取代的具有至少一个双键的有机基团，其任选地可以是活化的不饱和部分，例如（甲基）丙烯酸酯基团：例如1-正丙氧基（丙烯酸酯）或乙烯基; 和R 2和R 3各自独立地在每个任选的重复单元内代表任选取代的烃基，烃基（氧），氢氧化硅和/或氢氧化硅（氧）基团; 或例如甲基; 或三甲基甲硅烷氧基; R4独立地表示任选取代的具有至少一个双键（例如上述R 1）的任选取代的有机基团，和/或氢化硅基团，例如三甲基甲硅烷基或乙烯基; 并且n为约0至约2000; 优选约1至约100，例如n为1.这种聚合物前体可用于制备流动改性剂，消泡剂和/或压敏粘合剂。

公开(公告)号：US08072585B2

公开(公告)日：2011-12-06

申请号：US12650692

申请日：2009-12-31

申请人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

发明人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

IPC分类号： G01N21/00 ,  G01N21/64

CPC分类号： G01N21/6452 ,  G01N21/253

摘要： A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels.

摘要翻译： 一种多模式数据采集系统，用于检测生物反应表面上的目标材料，所述系统包括用于产生入射光束的辐射源，该入射光束以倾斜入射角度撞击在生物反应表面上并产生反射光束，干涉检测器 检测来自所述照射表面的干涉信号，所述反射光束被引导到所述干涉检测器;荧光检测器，用于检测来自被照射表面的荧光信号; 荧光检测器被定位成基本上最小化反射光束的入射; 以及用于接收干涉测量和荧光信号并确定生物反应表面上目标材料的存在或不存在的处理系统。 用于同时收集荧光，干涉仪和其他信号的反应表面。 一种多模式数据采集系统，用于收集和处理其他模式，包括多个干涉仪，荧光和散射通道。

公开(公告)号：US07981863B2

公开(公告)日：2011-07-19

申请号：US10246091

申请日：2002-09-18

申请人： Kioumars Delfani ,  Ann Marie Janson ,  H. Georg Kuhn ,  Karlheinz Plate ,  Anne Schanzer ,  Frank-Peter Wachs ,  Ming Zhao

发明人： Kioumars Delfani ,  Ann Marie Janson ,  H. Georg Kuhn ,  Karlheinz Plate ,  Anne Schanzer ,  Frank-Peter Wachs ,  Ming Zhao

IPC分类号： A61K38/00 ,  A61K38/18 ,  C12N5/00 ,  C12N5/079 ,  C12N5/0797 ,  C12N5/0793 ,  C07K14/49

CPC分类号： A61K38/1858 ,  A61K35/30 ,  A61K38/179 ,  A61K38/1866 ,  A61K45/06 ,  A61K48/00 ,  G01N33/5008 ,  G01N2333/49 ,  G01N2333/515 ,  A61K2300/00

摘要： The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells. These methods are useful for reducing at least one symptom of the disorder.

摘要翻译： 本发明一般涉及影响中枢神经系统细胞以产生可用于治疗CNS病症的后代的方法。 更具体地，本发明包括将患有这种病症的患者暴露于调节中枢神经系统细胞的增殖，迁移，分化和存活的试剂的方法。 这些方法可用于减少至少一种症状。

公开(公告)号：US20110167351A1

公开(公告)日：2011-07-07

申请号：US12790582

申请日：2010-05-28

申请人： Rakesh Kumar Arora ,  Keith William Paterson ,  Ming Zhao ,  Hong Albert Cai Wang ,  Dan Mihai Dumitru

发明人： Rakesh Kumar Arora ,  Keith William Paterson ,  Ming Zhao ,  Hong Albert Cai Wang ,  Dan Mihai Dumitru

IPC分类号： G06F3/01 ,  G06F15/16 ,  G06F3/048

CPC分类号： G06F17/211 ,  H04M1/72533 ,  H04M2250/02

摘要： A system and method are set forth for remotely controlling a presentation in a loop mode to allow the presentation to continue in the absence of a communication channel between the portable electronic device and remote presentation device. In particular, the portable electronic device can issue a command to the remote presentation device to present the presentation in loop mode so that a user of the portable electronic device can leave the vicinity of the remote presentation device (e.g. out of communication range) while the presentation plays in loop mode.

摘要翻译： 提出了一种用于以循环模式远程控制呈现的系统和方法，以允许呈现在便携式电子设备和远程呈现设备之间没有通信信道的情况下继续。 特别地，便携式电子设备可以向远程呈现设备发出命令以循环模式呈现呈现，使得便携式电子设备的用户可以离开远程呈现设备的附近（例如，不在通信范围内），同时 演示文稿以循环模式播放。

公开(公告)号：US20100145627A1

公开(公告)日：2010-06-10

申请号：US12650692

申请日：2009-12-31

申请人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

发明人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

IPC分类号： G01N33/48 ,  G01N21/00 ,  G06F19/00

CPC分类号： G01N21/6452 ,  G01N21/253

摘要： A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels.

摘要翻译： 一种多模式数据采集系统，用于检测生物反应表面上的目标材料，所述系统包括用于产生入射光束的辐射源，该入射光束以倾斜入射角度撞击在生物反应表面上并产生反射光束，干涉检测器 检测来自所述照射表面的干涉信号，所述反射光束被引导到所述干涉检测器;荧光检测器，用于检测来自被照射表面的荧光信号; 荧光检测器被定位成基本上最小化反射光束的入射; 以及用于接收干涉测量和荧光信号并确定生物反应表面上目标材料的存在或不存在的处理系统。 用于同时收集荧光，干涉仪和其他信号的反应表面。 一种多模式数据采集系统，用于收集和处理其他模式，包括多个干涉仪，荧光和散射通道。