Injection-resistant materials and method of making same through use of
nalidixic acid derivatives
    34.
    发明授权
    Injection-resistant materials and method of making same through use of nalidixic acid derivatives 失效
    耐注射材料及其通过使用萘啶酸衍生物制备方法

    公开(公告)号:US4563485A

    公开(公告)日:1986-01-07

    申请号:US605792

    申请日:1984-04-30

    Abstract: Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices. The material is rendered infection-resistant by incorporating therein antimicrobial agents, such as nalidixic acid derivatives or metal salts of nalidixic acid derivatives. In particular illustrative embodiments, silver norfloxacin and silver pefloxacin, are complexed with natural or synthetic polymeric materials such as silk, polyester (e.g., Dacron), polyurethane, polytetrafluoroethylene, or silicone-based material, to provide long-term prevention of infections which may otherwise result during or after surgery or implantation of a device.

    Abstract translation: 感染抗性材料及其制备方法,适合在人体或动物体内部以血管移植假体或其它植入装置的形式使用。 通过掺入其中的抗微生物剂,例如萘啶酸衍生物或萘啶酸衍生物的金属盐,使材料变得具有抗感染性。 特别说明性的实施例中,诺氟沙星银和普洛沙星银与天然或合成聚合材料如丝,聚酯(例如,涤纶),聚氨酯,聚四氟乙烯或硅氧烷基材料络合,以提供长期预防感染, 否则会在手术或植入手术期间或之后产生。

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