公开(公告)号：US20080281370A1

公开(公告)日：2008-11-13

申请号：US11744952

申请日：2007-05-07

申请人： Yayun Lin ,  Shelley M. Cazares ,  Donald L. Hopper

发明人： Yayun Lin ,  Shelley M. Cazares ,  Donald L. Hopper

IPC分类号： A61N1/02

CPC分类号： A61N1/3702 ,  A61B5/02028 ,  A61B5/02405 ,  A61B5/0464 ,  A61N1/3627 ,  A61N1/36592

摘要： An indication of an actual or potential heart failure condition is computed. One example includes monitoring a first heart rate preceding a first onset of a first sinus tachyarrhythmia episode. Upon detecting the first sinus tachyarrhythmia episode, the indication is automatically provided using information about the first heart rate and how quickly the first onset occurs.

摘要翻译： 计算出实际或潜在的心力衰竭状况的指示。 一个例子包括监测在第一次窦性心律失常发作的第一次发作之前的第一心率。 在检测到第一窦性心律失常发作时，使用关于第一心率的信息以及第一次发作发生的速度自动提供指示。

公开(公告)号：US06917830B2

公开(公告)日：2005-07-12

申请号：US10643770

申请日：2003-08-19

申请人： Surekha Palreddy ,  Carlos Ricci ,  Yayun Lin

发明人： Surekha Palreddy ,  Carlos Ricci ,  Yayun Lin

IPC分类号： A61B5/0452 ,  A61B5/046 ,  A61N1/37 ,  A61B5/04

CPC分类号： A61B5/0452 ,  A61B5/046 ,  A61B5/7221 ,  A61N1/37 ,  A61N1/3704 ,  A61N1/3718 ,  Y10S128/901

摘要： An implantable cardiac rhythm management device is configured to estimating the noise level and noise floor in a sensing channel by measuring the magnitude of signal in the sensing channel when noise is determined to be present or absent, respectively. The presence or absence of noise may be determined by computing the density of local peaks or inflection points in an electrogram waveform. The computed local peak density is then used to set or clear a noise flag, which signifies whether noise is present or not. A noise statistic computed from samples of the electrogram signal obtained through a sensing channel may then be used to estimate a noise level or a noise floor.

摘要翻译： 可植入心律管理装置被配置为通过分别在确定噪声存在或不存在时通过测量感测通道中的信号的幅度来估计感测通道中的噪声电平和噪声底限。 噪声的存在或不存在可以通过计算电描记图波形中局部峰值或拐点的密度来确定。 然后使用计算的局部峰值密度来设置或清除噪声标志，其表示是否存在噪声。 然后可以使用从通过感测通道获得的电描记图信号的样本计算的噪声统计量来估计噪声水平或噪声底噪。

公开(公告)号：US06251125B1

公开(公告)日：2001-06-26

申请号：US09053115

申请日：1998-04-01

申请人： Bruce H. KenKnight ,  William Hsu ,  Yayun Lin ,  Janice Jones

发明人： Bruce H. KenKnight ,  William Hsu ,  Yayun Lin ,  Janice Jones

IPC分类号： A61N139

CPC分类号： A61N1/3962

摘要： A method and system for ventricular defibrillation by coordinating the delivery of defibrillation shocks with sensed ventricular fibrillation complexes in a way which improves the probability of success of the defibrillation shock. Ventricular electrical activity is monitored in two ventricular locations during ventricular fibrillation to detect coarse ventricular fibrillation complexes and contractions of the ventricular cardiac tissue. The defibrillation shock is delivered in coordination with the occurrence of coarse ventricular fibrillation complexes and the contractions of ventricular cardiac tissue, and specifically to occur on the up-slope portion thereof, for optimal probability of success.

摘要翻译： 通过以提高除颤休克成功概率的方式协调将感染的心室颤动复合物递送除颤电击的心室除颤的方法和系统。 在心室纤维性颤动期间，在两个心室位置监测心室电活动，以检测心室心脏组织的粗略心室颤动复合物和收缩。 伴随发生粗心室颤动复合物和心室心脏组织的收缩，特别是在其上坡部分发生除颤休克，以获得最佳的成功概率。

公开(公告)号：US06212434B1

公开(公告)日：2001-04-03

申请号：US09120824

申请日：1998-07-22

申请人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W. Goebel ,  Douglas A. Heitkamp ,  Randall M. Peterfeso

发明人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W. Goebel ,  Douglas A. Heitkamp ,  Randall M. Peterfeso

IPC分类号： A61N105

CPC分类号： A61N1/0573 ,  A61N1/0563

摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

公开(公告)号：US06839591B2

公开(公告)日：2005-01-04

申请号：US10396946

申请日：2003-03-24

申请人： Bruce H. KenKnight ,  William Hsu ,  Yayun Lin ,  Janice Jones

发明人： Bruce H. KenKnight ,  William Hsu ,  Yayun Lin ,  Janice Jones

IPC分类号： A61N1/39

CPC分类号： A61N1/3962

摘要： A method and system for ventricular defibrillation by coordinating the delivery of defibrillation shocks with sensed ventricular fibrillation complexes in a way which improves the probability of success of the defibrillation shock. Ventricular electrical activity is monitored in two ventricular locations during ventricular fibrillation to detect coarse ventricular fibrillation complexes and contractions of the ventricular cardiac tissue. The defibrillation shock is delivered in coordination with the occurrence of coarse ventricular fibrillation complexes and the contractions of ventricular cardiac tissue, and specifically to occur on the up-slope portion thereof, for optimal probability of success.

公开(公告)号：US06505082B1

公开(公告)日：2003-01-07

申请号：US09643125

申请日：2000-08-21

申请人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W Goebel ,  Douglas A Heitkamp ,  Randall M. Peterfeso

发明人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W Goebel ,  Douglas A Heitkamp ,  Randall M. Peterfeso

IPC分类号： A61N105

CPC分类号： A61N1/0573 ,  A61N1/0563

摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

公开(公告)号：US06256541B1

公开(公告)日：2001-07-03

申请号：US09062268

申请日：1998-04-17

申请人： John E. Heil ,  Ronald W. Heil, Jr. ,  Avram Scheiner ,  Yayun Lin ,  Lyle A. Bye ,  J. John Lattuca

发明人： John E. Heil ,  Ronald W. Heil, Jr. ,  Avram Scheiner ,  Yayun Lin ,  Lyle A. Bye ,  J. John Lattuca

IPC分类号： A61N105

CPC分类号： A61N1/0563 ,  A61N1/0573

摘要： An endocardial lead comprising an elongate body having a first defibrillation coil electrode, a second defibrillation coil electrode and a first pacing/sensing electrode. The first defibrillation coil electrode has a first end and a second end, where the first end is at or near the distal end of the elongate body and the second end spaced longitudinally from the distal end. The first pacing/sensing electrode is spaced longitudinally along the peripheral surface from the second end of the first defibrillation coil electrode. The second defibrillation coil electrode is spaced longitudinally along the peripheral surface from the first pacing/sensing electrode to afford positioning the first defibrillation coil longitudinally adjacent an apical location of the right ventricle of a heart with the first pacing/sensing electrode within the right ventricle of the heart and the second defibrillation coil within the right atrial chamber or a major vein leading to the right atrial chamber of the heart. The elongate body further includes a curved portion on which the first pacing/sensing electrode is positioned such that the first pacing/sensing electrode extends beyond the peripheral surface of the elongate body to engage the tissue of the heart. The first pacing/sensing electrode further includes a retaining element, where the retaining element is adapted to be embedded in the right ventricle of the heart to secure the first pacing/sensing electrode and the elongate body of the endocardial lead to the right ventricle of the heart.

摘要翻译： 一种心内膜，其包括具有第一除颤线圈电极，第二除颤线圈电极和第一起搏感测电极的细长体。 第一除颤线圈电极具有第一端和第二端，其中第一端处于细长体的远端处或其附近，并且第二端与远端纵向间隔开。 第一起搏感测电极沿着与第一除颤线圈电极的第二端的外周表面纵向间隔开。 第二除颤线圈电极沿着与第一起搏/感测电极的外周表面纵向间隔开，以使第一除颤线圈与心脏右心室的顶端位置纵向相邻，其中第一起搏/感测电极位于右心室内 右心房中的心脏和第二除颤线圈或通向心脏右心房的主要静脉。 细长主体还包括弯曲部分，第一起搏/感测电极定位在弯曲部分上，使得第一起搏/感测电极延伸超出细长体的周边表面以接合心脏的组织。 第一起搏/感测电极还包括保持元件，其中保持元件适于嵌入心脏的右心室，以将第一起搏/感测电极和心内膜引导件的细长体固定到右心室 心。

公开(公告)号：US6112117A

公开(公告)日：2000-08-29

申请号：US852103

申请日：1997-05-06

申请人： Bruce H. KenKnight ,  William Hsu ,  Yayun Lin ,  Janice Jones

发明人： Bruce H. KenKnight ,  William Hsu ,  Yayun Lin ,  Janice Jones

IPC分类号： A61N1/39

CPC分类号： A61N1/3962

摘要： A method and system for ventricular defibrillation by coordinating the delivery of defibrillation shocks with sensed ventricular fibrillation complexes in a way which improves the probability of success of the defibrillation shock. Ventricular electrical activity is monitored in two ventricular locations during ventricular fibrillation to detect coarse ventricular fibrillation complexes and contractions of the ventricular cardiac tissue. The defibrillation shock is delivered in coordination with the occurrence of coarse ventricular fibrillation complexes and the contractions of ventricular cardiac tissue, and specifically to occur on the up-slope portion thereof, for optimal probability of success.

公开(公告)号：US5632766A

公开(公告)日：1997-05-27

申请号：US513685

申请日：1995-08-11

申请人： William Hsu ,  Yayun Lin

发明人： William Hsu ,  Yayun Lin

IPC分类号： A61N1/39

CPC分类号： A61N1/3956

摘要： A method and system for ventricular defibrillation by coordinating the delivery of defibrillation shocks with sensed ventricular fibrillation complexes in a way which improves the probability of success of the defibrillation shock. Ventricular electrical activity is monitored during VF to detect coarse VF complexes. The defibrillation shock is delivered in coordination with the occurrence of coarse VF complexes, and specifically to occur on the upslope portion thereof, for optimal probability of success. Preferably, DF shock is delivered on the nth occurring coarse VF complex, wherein n is equal to or greater than 2 and less than or equal to about 9.

摘要翻译： 通过以提高除颤休克成功的可能性的方式协调将感染的心室颤动复合物的除颤电击的递送来协调心室除颤的方法和系统。 在VF期间监测心室电活动以检测粗VF复合物。 与除了VF组合物的发生相一致地进行除颤休克，特别是在其上坡部分发生，以获得最佳的成功概率。 优选地，DF冲击在第n个出现的粗VF复合物上递送，其中n等于或大于2且小于或等于约9。