公开(公告)号：US08380303B2

公开(公告)日：2013-02-19

申请号：US13035793

申请日：2011-02-25

申请人： Stuart Rosenberg ,  Cecilia Q. Xi ,  Yelena Nabutovsky ,  Brian J. Wenzel ,  Jong Gill ,  William Hsu

发明人： Stuart Rosenberg ,  Cecilia Q. Xi ,  Yelena Nabutovsky ,  Brian J. Wenzel ,  Jong Gill ,  William Hsu

IPC分类号： A61N1/00

CPC分类号： A61B5/0538 ,  A61B5/686 ,  A61N1/36507 ,  A61N1/36521 ,  A61N1/36592 ,  A61N1/3684

摘要： Techniques are provided for use with implantable medical devices for addressing encapsulation effects, particularly in the detection of cardiac decompensation events such as heart failure (HF) or cardiogenic pulmonary edema (PE.) In one example, during an acute interval following device implant, cardiac decompensation is detected using heart rate variability (HRV), ventricular evoked response (ER) or various other non-impedance-based parameters that are insensitive to component encapsulation effects. During the subsequent chronic interval, decompensation is detected using intracardiac or transthoracic impedance signals. In another example, the degree of maturation of encapsulation of implanted components is assessed using impedance frequency-response measurements or based on the frequency bandwidth of heart sounds or other physiological signals. In this manner, impedance-based HF/PE detection systems can be activated as soon as component encapsulation has matured, without necessarily waiting until completion of a preset post-implant maturation interval, often set to forty-five days or more.

摘要翻译： 提供技术用于可植入医疗装置，用于解决封装效应，特别是在心脏代偿失调事件如心力衰竭（HF）或心源性肺水肿（PE）的检测中。在一个实例中，在装置植入后的急性期间，心脏 使用心率变异性（HRV），心室诱发反应（ER）或对组件封装效应不敏感的各种其他基于非阻抗的参数来检测代偿失调。 在随后的慢性间隔期间，使用心内或经胸阻抗信号检测代偿失调。 在另一示例中，使用阻抗频率响应测量值或基于心脏声音或其他生理信号的频率带宽来评估植入部件的封装的成熟程度。 以这种方式，一旦组件封装已经成熟，就可以激活基于阻抗的HF / PE检测系统，而不必等待直到完成植入后成熟间隔的预设，通常设置为四十五天或更长时间。

公开(公告)号：US20120221069A1

公开(公告)日：2012-08-30

申请号：US13035793

申请日：2011-02-25

申请人： Stuart Rosenberg ,  Cecilia Qin Xi ,  Yelena Nabutovsky ,  Brian Jeffrey Wenzel ,  Jong Gill ,  William Hsu

发明人： Stuart Rosenberg ,  Cecilia Qin Xi ,  Yelena Nabutovsky ,  Brian Jeffrey Wenzel ,  Jong Gill ,  William Hsu

IPC分类号： A61N1/365

CPC分类号： A61B5/0538 ,  A61B5/686 ,  A61N1/36507 ,  A61N1/36521 ,  A61N1/36592 ,  A61N1/3684

摘要： Techniques are provided for use with implantable medical devices for addressing encapsulation effects, particularly in the detection of cardiac decompensation events such as heart failure (HF) or cardiogenic pulmonary edema (PE.) In one example, during an acute interval following device implant, cardiac decompensation is detected using heart rate variability (HRV), ventricular evoked response (ER) or various other non-impedance-based parameters that are insensitive to component encapsulation effects. During the subsequent chronic interval, decompensation is detected using intracardiac or transthoracic impedance signals. In another example, the degree of maturation of encapsulation of implanted components is assessed using impedance frequency-response measurements or based on the frequency bandwidth of heart sounds or other physiological signals. In this manner, impedance-based HF/PE detection systems can be activated as soon as component encapsulation has matured, without necessarily waiting until completion of a preset post-implant maturation interval, often set to forty-five days or more.

公开(公告)号：USD623819S1

公开(公告)日：2010-09-14

申请号：US29331546

申请日：2009-01-27

申请人： Frank Yang ,  Tzu-Hao Wei ,  William Hsu ,  Di-Fong Chang

设计人： Frank Yang ,  Tzu-Hao Wei ,  William Hsu ,  Di-Fong Chang

公开(公告)号：USD574569S1

公开(公告)日：2008-08-05

申请号：US29293145

申请日：2007-11-06

申请人： Frank Yang ,  Tzu-Hao Wei ,  Di-Fong Chang ,  William Hsu

设计人： Frank Yang ,  Tzu-Hao Wei ,  Di-Fong Chang ,  William Hsu

公开(公告)号：US07203535B1

公开(公告)日：2007-04-10

申请号：US09417558

申请日：1999-10-13

申请人： William Hsu ,  Robert J. Sweeney ,  Eric G. Lovett

发明人： William Hsu ,  Robert J. Sweeney ,  Eric G. Lovett

IPC分类号： A61B5/0402

CPC分类号： A61N1/3622 ,  A61N1/3962

摘要： An implantable cardioverter/defibrillator includes a tachycardia detection system that detects one-to-one (1:1) tachycardia, which is a tachycardia with a one-to-one relationship between atrial and ventricular contractions. When the 1:1 tachycardia is detected, the system discriminates ventricular tachycardia (VT) from supraventricular tachycardia (SVT) based on analysis of a cardiac time interval. Examples of the cardiac time interval include an atrioventricular interval (AVI) and a ventriculoatrial interval (VAI). A template time interval is created during a known normal sinus rhythm. The system measures a tachycardia time interval after detecting the 1:1 tachycardia, and indicates a VT detection if the tachycardia time interval differs from the template time interval by at least a predetermined percentage of the template time interval.

摘要翻译： 用于区分沿逆行方向发生的心律的顺行方向发生的心律的系统和方法。 感觉心房去极化和心室去极化。 当检测到心房去极化与心脏去极化具有一对一关联的心动过速发作时，测量心室去极化与第一预定心脏事件之间的第一间隔以及心房去极化和第二预定心脏事件之间的第二间隔。 然后将第一和第二间隔的特征用于将心动过速发作分类为顺行节律或逆行节律。

公开(公告)号：US20060211949A1

公开(公告)日：2006-09-21

申请号：US11422772

申请日：2006-06-07

申请人： Robert Sweeney ,  William Hsu

发明人： Robert Sweeney ,  William Hsu

IPC分类号： A61B5/04

CPC分类号： A61B5/7264 ,  A61B5/042 ,  A61B5/04525 ,  A61N1/3962

摘要： A system and method for classifying cardiac depolarization complexes in which waveforms of a depolarization complex are sensed by separate electrodes and correlated with template waveforms of a template depolarization complex. The system is particularly suitable for incorporation into a cardiac rhythm management device such as an implantable cardioverter/defibrillator or pacemaker in order to facilitate arrhythmia prediction and/or prevention.

公开(公告)号：US20060167913A1

公开(公告)日：2006-07-27

申请号：US11044402

申请日：2005-01-27

申请人： Chi Tam ,  William Hsu

发明人： Chi Tam ,  William Hsu

IPC分类号： G06F17/00

CPC分类号： G06F16/9554

摘要： In a data structure such as an electronic document, a location such as an address is entered, rendered, or scanned for as part of text of the data structure. The location is identified and is converted to a hyperlink that targets an application program such as a website. When activated, the hyperlink takes a user to the application program.

摘要翻译： 在诸如电子文档的数据结构中，诸如地址的位置作为数据结构的文本的一部分被输入，呈现或扫描。 该位置被识别并被转换为针对诸如网站的应用程序的超链接。 激活时，超链接将用户转到应用程序。

公开(公告)号：US07044316B1

公开(公告)日：2006-05-16

申请号：US10697145

申请日：2003-10-28

申请人： William Hsu

发明人： William Hsu

IPC分类号： A61J11/02

CPC分类号： A61J11/02 ,  A61J9/006 ,  A61J11/0005

摘要： A straw set with a ventilating structure includes a nipple connected to a circular base with a circular air guiding trench, an air hole that passes through, and a chamber with two axles attached underneath. Underneath, a straw base consists of an inner circular wall fixed to the nipple, an outer circular wall fixed to the bottom of the circular base, another circular air guiding trench concaved between the inner and the outer circular walls, and a hollow pipe protruding downwards. The straw base is supported by a soft plastic circular base with a hole at the center, a second outer circular wall expanded upward to fix upon the first outer circular wall, a air guiding trench expanded downward from the edge of the second outer circular wall, and another air hole that passes through the soft plastic circular base.

摘要翻译： 具有通风结构的吸管组包括连接到具有圆形空气引导沟槽的圆形底座的乳头，穿过的空气孔以及连接在其下方的两个轴的室。 在下面，吸管基部由固定在乳头上的内部圆形壁，固定在圆形底部底部的外部圆形壁，另一个在内部和外部圆形壁之间凹陷的圆形空气引导沟槽以及向下突出的中空管 。 秸秆基座由中心具有孔的软塑料圆形基座支撑，向上扩展的第二外部圆形壁固定在第一外部圆形壁上，从第二外部圆形壁的边缘向下扩展的导气沟槽， 另一个通孔穿过软塑料圆形底座。

公开(公告)号：US20060079796A1

公开(公告)日：2006-04-13

申请号：US11287631

申请日：2005-11-28

申请人： Alan Marcovecchio ,  William Hsu

发明人： Alan Marcovecchio ,  William Hsu

IPC分类号： A61B5/04

CPC分类号： A61B5/04525

摘要： A method and system for verifying the integrity of normal sinus rhythm (NSR) templates and updating the NSR template after selected time intervals. At selected time intervals after establishing a NSR template, cardiac complexes are sensed and values for one or more cardiac parameters are measured. The values of the cardiac parameters are compared to predetermined value ranges for NSR cardiac complexes. When the values of the cardiac parameters fall within the predetermined value ranges, values for the differences between the values of the cardiac parameters for the cardiac complexes and the values for the cardiac parameters of the NSR cardiac complexes are calculated. When the values of the differences are greater than one or more threshold values, the NSR template is updated as a function of the sensed cardiac complexes.

公开(公告)号：US20050236353A1

公开(公告)日：2005-10-27

申请号：US10835145

申请日：2004-04-27

申请人： William Hsu

发明人： William Hsu

IPC分类号： A61J9/04 ,  A61J9/08 ,  A61J11/02

CPC分类号： A61J9/006 ,  A61J9/04 ,  A61J11/002 ,  A61J11/02

摘要： A flatulency-preventing device is associated with a nursing bottle, and includes a fluid guide fitted between a nipple and a body of the nursing bottle to define a one-direction flowing path in the bottle, and an air bubble collector fitted around a lower rim of the fluid guide to locate in the body of the nursing bottle. Air rushing into the bottle at the instant of releasing of the sucked nipple is guided into the air bubble collector via the fluid guide to gather up at a bottom of the nursing bottle without mixing with the fluid in the bottle and being sucked into a baby's stomach to cause undesirable flatulency.

摘要翻译： 封闭容积装置与护理瓶相关联，并且包括装配在乳头和护理瓶的主体之间的流体导向件，以在瓶子中限定单向流动路径，以及围绕下边缘装配的气泡收集器 的流体导管位于护理瓶的身体内。 在抽吸乳头释放瞬间冲入瓶子的空气通过流体引导件引导到气泡收集器中，以收集在护理瓶的底部，而不与瓶子中的流体混合并被吸入婴儿的胃 导致不良的膨胀。