公开(公告)号：US06212434B1

公开(公告)日：2001-04-03

申请号：US09120824

申请日：1998-07-22

申请人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W. Goebel ,  Douglas A. Heitkamp ,  Randall M. Peterfeso

发明人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W. Goebel ,  Douglas A. Heitkamp ,  Randall M. Peterfeso

IPC分类号： A61N105

CPC分类号： A61N1/0573 ,  A61N1/0563

摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

公开(公告)号：US06505082B1

公开(公告)日：2003-01-07

申请号：US09643125

申请日：2000-08-21

申请人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W Goebel ,  Douglas A Heitkamp ,  Randall M. Peterfeso

发明人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W Goebel ,  Douglas A Heitkamp ,  Randall M. Peterfeso

IPC分类号： A61N105

CPC分类号： A61N1/0573 ,  A61N1/0563

摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

公开(公告)号：US06345204B1

公开(公告)日：2002-02-05

申请号：US09661531

申请日：2000-09-14

申请人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Qingsheng Zhu ,  Peter T. Kelley ,  David M. Flynn ,  John E. Heil

发明人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Qingsheng Zhu ,  Peter T. Kelley ,  David M. Flynn ,  John E. Heil

IPC分类号： A61N105

CPC分类号： A61N1/0573

摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity including a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface which is for positioning within the ventricle of the heart. The lead body also has a second electrode which has a second electrical conducting surface adapted for positioning within the atrium of the heart. Both of the first and the second electrodes are adapted for positioning and fixation to the wall. An active fixation element is used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and fixing of the second electrode. In another embodiment, the main lead body includes a recess into which an atrial lead body and the active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element which can also be moved by turning the terminal pin.

摘要翻译： 一种单程心内膜引导电极，其适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统，包括具有周向外表面的引线体。 引线包括第一远端电极，其具有用于定位在心脏心室内的第一导电表面。 引线体还具有第二电极，该第二电极具有适于定位在心脏心房内的第二导电表面。 第一和第二电极都适于定位和固定在墙上。 活性固定元件用作第二电极的一部分。 引线体还包括有助于第二电极的定位和固定的弯曲部分。在另一实施例中，主引线体包括凹部，其中一个端部的心房引线体和主动固定元件可以从凹部 位置到固定在心脏壁上的位置。 主动固定元件也可以通过转动端子销来移动。

公开(公告)号：US6152954A

公开(公告)日：2000-11-28

申请号：US121006

申请日：1998-07-22

申请人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Qingsheng Zhu ,  Peter T. Kelley ,  David M. Flynn ,  John E. Heil

发明人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Qingsheng Zhu ,  Peter T. Kelley ,  David M. Flynn ,  John E. Heil

IPC分类号： A61N1/05

CPC分类号： A61N1/0573

摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity including a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface which is for positioning within the ventricle of the heart. The lead body also has a second electrode which has a second electrical conducting surface adapted for positioning within the atrium of the heart. Both of the first and the second electrodes are adapted for positioning and fixation to the wall. An active fixation element is used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and fixing of the second electrode. In another embodiment, the main lead body includes a recess into which an atrial lead body and the active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element which can also be moved by turning the terminal pin.

摘要翻译： 一种单程心内膜引导电极，其适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统，包括具有周向外表面的引线体。 引线包括第一远端电极，其具有用于定位在心脏心室内的第一导电表面。 引线体还具有第二电极，该第二电极具有适于定位在心脏心房内的第二导电表面。 第一和第二电极都适于定位和固定在墙上。 活性固定元件用作第二电极的一部分。 引线体还包括有助于第二电极的定位和固定的弯曲部分。 在另一个实施例中，主引线主体包括凹部，其中安装在一端的心房引线主体和主动固定元件可以从凹陷位置行进到用于固定到心脏壁的位置。 主动固定元件也可以通过转动端子销来移动。

公开(公告)号：US07225024B2

公开(公告)日：2007-05-29

申请号：US10677144

申请日：2003-09-30

申请人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

发明人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

IPC分类号： A61N1/365 ,  A61B5/00

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61N1/0568

摘要： A cardiac management implantable device that has an intravascular device body, and one or more chemical sensors coupled with the intravascular device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

摘要翻译： 一种具有血管内装置体的心脏管理可植入装置，以及与血管内装置本体结合的一个或多个化学传感器。 药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

公开(公告)号：US08131364B2

公开(公告)日：2012-03-06

申请号：US12984161

申请日：2011-01-04

申请人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

发明人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

IPC分类号： A61N1/00

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61N1/0568

摘要： An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

摘要翻译： 一种装置包括可植入装置，例如具有装置主体的长期可植入装置。 一个或多个化学传感器与装置本体结合。 药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

公开(公告)号：US07890171B2

公开(公告)日：2011-02-15

申请号：US11738251

申请日：2007-04-20

申请人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

发明人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

IPC分类号： A61N1/00

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61N1/0568

摘要： An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

摘要翻译： 一种装置包括可植入装置，例如具有装置主体的长期可植入装置。 一个或多个化学传感器与装置本体结合。 药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

公开(公告)号：US06363286B1

公开(公告)日：2002-03-26

申请号：US09406207

申请日：1999-09-24

申请人： Qingsheng Zhu ,  Ronald W. Heil, Jr.

发明人： Qingsheng Zhu ,  Ronald W. Heil, Jr.

IPC分类号： A61N105

CPC分类号： A61N1/0568 ,  A61N1/056

摘要： A lead having an electrode assembly has a high impedance electrode. The high impedance electrode includes a partially insulated sleeve electrode or a wire filament. The high impedance electrode includes an exposed surface of less than 1.2 MM2. One or more eluting drugs are disposed adjacent to the high impedance electrode.

摘要翻译： 具有电极组件的引线具有高阻抗电极。 高阻抗电极包括部分绝缘的套管电极或电线丝。 高阻抗电极包括小于1.2MM2的暴露表面。 一个或多个洗脱药物设置在高阻抗电极附近。

公开(公告)号：US20110098547A1

公开(公告)日：2011-04-28

申请号：US12984161

申请日：2011-01-04

申请人： Qingsheng Zhu ,  Ronald W. Heil, JR. ,  Mudit Jain

发明人： Qingsheng Zhu ,  Ronald W. Heil, JR. ,  Mudit Jain

IPC分类号： A61B5/145

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61N1/0568

摘要： An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

摘要翻译： 一种装置包括可植入装置，例如具有装置主体的长期可植入装置。 一个或多个化学传感器与装置本体结合。 药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

公开(公告)号：US06889092B2

公开(公告)日：2005-05-03

申请号：US10034503

申请日：2001-12-28

申请人： Qingsheng Zhu ,  Ronald W. Heil, Jr.

发明人： Qingsheng Zhu ,  Ronald W. Heil, Jr.

IPC分类号： A61N1/05

CPC分类号： A61N1/0568 ,  A61N1/056

摘要： A lead having an electrode assembly has a high impedance electrode. The high impedance electrode includes a partially insulated sleeve electrode or a wire filament. The high impedance electrode includes an exposed surface of less than 1.2 mm2. One or more eluting drugs are disposed adjacent to the high impedance electrode.

摘要翻译： 具有电极组件的引线具有高阻抗电极。 高阻抗电极包括部分绝缘的套管电极或电线丝。 高阻抗电极包括小于1.2mm 2的暴露表面。 一个或多个洗脱药物设置在高阻抗电极附近。