-
公开(公告)号：US08217177B2
公开(公告)日：2012-07-10
申请号：US12009123
申请日：2008-01-15
申请人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Alessandro Boezio , Deborah Choquette , Jean-Christophe Harmange , Julia Lohman , Michele Potashman
发明人： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Alessandro Boezio , Deborah Choquette , Jean-Christophe Harmange , Julia Lohman , Michele Potashman
IPC分类号： C07D487/04 , A61K31/4162 , A61K31/437 , A61P35/00
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
-
公开(公告)号：US20060040966A1
公开(公告)日：2006-02-23
申请号：US11185556
申请日：2005-07-19
申请人： Chester Yuan , Kevin Yang , Simon Van Der Plas , Babak Riahi , Michele Potashman , Vinod Patel , Rana Nomak , Aiwen Li , Qi Huang , Jean-Christophe Harmange , Benny Askew
发明人： Chester Yuan , Kevin Yang , Simon Van Der Plas , Babak Riahi , Michele Potashman , Vinod Patel , Rana Nomak , Aiwen Li , Qi Huang , Jean-Christophe Harmange , Benny Askew
IPC分类号： A61K31/517 , A61K31/4433 , C07D405/02 , C07D401/02
CPC分类号： C07D401/12 , C07D217/02 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds of Formula I and II wherein R, R1 and R2 for each formula are defined herein. The invention further includes analogs, prodrugs and pharmaceutically acceptable salts and derivatives of Formulas I and II, as well as pharmaceutical compositions, medicaments and methods thereof for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 选择的胺对于预防和治疗疾病如血管生成介导的疾病是有效的。 本发明包括式I和II的新型化合物，其中R 1，R 1和R 2各自在本文中定义。 本发明还包括式I和II的类似物，前药和药学上可接受的盐和衍生物，以及用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物，药物及其方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号：US20090143355A1
公开(公告)日：2009-06-04
申请号：US12322361
申请日：2009-01-29
申请人： Chester Chenguang Yuan , Kevin Yang , Simon Van Der Plas , Babak Riahi , Michele Potashman , Vinod F. Patel , Rana Nomak , Aiwen Li , Qi Huang , Jean-Christophe Harmange , Benny C. Askew, JR.
发明人： Chester Chenguang Yuan , Kevin Yang , Simon Van Der Plas , Babak Riahi , Michele Potashman , Vinod F. Patel , Rana Nomak , Aiwen Li , Qi Huang , Jean-Christophe Harmange , Benny C. Askew, JR.
IPC分类号： A61K31/517 , C07D401/02 , A61P35/00 , C07D413/14 , A61K31/4725 , A61K31/496 , C07D401/14
CPC分类号： C07D401/12 , C07D217/02 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds of Formula I and II wherein R, R1 and R2 for each formula are defined herein. The invention further includes analogs, prodrugs and pharmaceutically acceptable salts and derivatives of Formulas I and II, as well as pharmaceutical compositions, medicaments and methods thereof for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
-
公开(公告)号：US20140371206A1
公开(公告)日：2014-12-18
申请号：US14313148
申请日：2014-06-24
申请人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
发明人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC分类号： C07D498/04
CPC分类号： C07D498/04 , A61K31/424 , A61K31/55 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/4702
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
-
公开(公告)号：US20140135316A1
公开(公告)日：2014-05-15
申请号：US14114983
申请日：2012-05-04
申请人： Brian K. Albrecht , Victor S. Gehling , Michael C. Hewitt , Alexander M. Taylor , Jean-Christophe Harmange
发明人： Brian K. Albrecht , Victor S. Gehling , Michael C. Hewitt , Alexander M. Taylor , Jean-Christophe Harmange
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
-
公开(公告)号：US20110118285A1
公开(公告)日：2011-05-19
申请号：US12994068
申请日：2009-05-22
申请人： Brian K. Albrecht , Steven Bellon , Christiane Bode , Alessandro Boezio , Deborah Choquette , Jean-Christophe Harmange
发明人： Brian K. Albrecht , Steven Bellon , Christiane Bode , Alessandro Boezio , Deborah Choquette , Jean-Christophe Harmange
IPC分类号： A61K31/519 , C07D498/02 , A61K31/437 , A61P35/00 , A61P35/04
CPC分类号： C07D471/04
摘要： Selected fused imidazole or triazole derivatives are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 选择的稠合咪唑或三唑衍生物可有效预防和治疗诸如HGF介导的疾病之类的疾病。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号：US20080161346A1
公开(公告)日：2008-07-03
申请号：US12004156
申请日：2007-12-19
IPC分类号： A61K31/4725 , C07D217/00 , A61K31/47 , A61P29/00
CPC分类号： C07D401/06 , C07D401/14 , C07D417/14
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as VEGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 选择的化合物对于预防和治疗诸如VEGF介导的疾病的疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号：US07115617B2
公开(公告)日：2006-10-03
申请号：US10225819
申请日：2002-08-21
IPC分类号： C07D413/12 , A61K31/422 , C07D239/48
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.
-
公开(公告)号：US09249161B2
公开(公告)日：2016-02-02
申请号：US13990906
申请日：2011-12-02
申请人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
发明人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC分类号： C07D513/20 , C07D498/10 , C07D487/10 , C07D495/22 , C07D495/14 , C07D495/20 , C07D498/04 , C07D498/14 , C07D513/14
CPC分类号： C07D513/20 , C07D487/10 , C07D495/14 , C07D495/20 , C07D495/22 , C07D498/04 , C07D498/10 , C07D498/14 , C07D513/14
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
-
公开(公告)号：US08796261B2
公开(公告)日：2014-08-05
申请号：US13309646
申请日：2011-12-02
申请人： Brian K. Albrecht , James E. Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael C. Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
发明人： Brian K. Albrecht , James E. Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael C. Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC分类号： A61K31/55 , C07D498/04 , C07D498/20 , C07K14/47 , C07D498/14 , C07D498/22
CPC分类号： C07D498/04 , A61K31/424 , A61K31/55 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/4702
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作含溴结构域蛋白质的抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
-
-
-
-
-
-
-
-
-
搜索结果
66 条记录 (耗时 0.05 秒)
