METHOD OF USING CD1D OVER-EXPRESSION IN HUMAN DENDRITIC CELLS TO ENHANCE CD8+ T CELL-BASED AND INVARIANT NATURAL KILLER T CELL-BASED ANTITUMOR IMMUNITY
    31.
    发明申请
    METHOD OF USING CD1D OVER-EXPRESSION IN HUMAN DENDRITIC CELLS TO ENHANCE CD8+ T CELL-BASED AND INVARIANT NATURAL KILLER T CELL-BASED ANTITUMOR IMMUNITY 审中-公开
    在人类细胞中使用CD1D超表达以增强基于CD8 + T细胞和不定性自然杀伤T细胞的抗体免疫的方法

    公开(公告)号:US20130344095A1

    公开(公告)日:2013-12-26

    申请号:US14004413

    申请日:2012-03-09

    Abstract: The manipulation of human dendritic cells (DCs) to induce potent anti-tumor immunity remains an essential subject of study. Here we report that the overexpression of CD1d in human DCs can enhance the priming of naïve CD8+ T cells against tumor antigen. We showed that CD1d can be overexpressed in the human DCs using baculoviral vector carrying the CD1d gene. This CD1d-overexpression is functional as demonstrated by the increased expansion of invariant natural killer T (iNKT) cells while using these modified DCs to present α-galactosylceramide (α-GC). Pulsed with tumor antigenic peptide, these CD1d-overexpressing human DCs showed enhanced capability to prime naïve CD8+ T cells. CD1d-overexpressing human DCs also induced a pro-inflammatory cytokine profile that may favor the priming. Moreover, this CD1d-overexpression strategy can be extrapolated to monocyte-derived human DCs. Therefore, our study suggest that overexpression of CD1d in human DCs may provide a novel strategy to enhance DC immunogenicity and the possible translation into human cancer immunotherapy.

    Abstract translation: 人类树突状细胞(DCs)的操纵诱导有效的抗肿瘤免疫仍然是研究的重要课题。 我们报告说,CD1d在人类DCs中的过表达可以增强初始的CD8 + T细胞对肿瘤抗原的启动。 我们显示CD1d可以使用携带CD1d基因的杆状病毒载体在人DC中过表达。 这种CD1d过表达是功能性的,通过增加不变性天然杀伤T(iNKT)细胞的扩增,而使用这些修饰的DCs来呈现α-半乳糖神经酰胺(α-GC)。 脉冲与肿瘤抗原肽,这些CD1d过度表达的人DCs显示增强的能力,以初始的初始CD8 + T细胞。 CD1d过表达的人DC也诱导促炎细胞因子谱,可能有利于引发。 此外,这种CD1d过表达策略可以外推到单核细胞衍生的人类DCs。 因此,我们的研究表明CD1d在人类DCs中的过表达可能提供增强DC免疫原性和可能转化为人类癌症免疫治疗的新策略。

    Apparatus, method and system for reduced active set management
    32.
    发明授权
    Apparatus, method and system for reduced active set management 有权
    减少活动集管理的装置,方法和系统

    公开(公告)号:US08472921B2

    公开(公告)日:2013-06-25

    申请号:US12704794

    申请日:2010-02-12

    CPC classification number: H04W24/02 H04B7/18515

    Abstract: A first communication device wirelessly coupled to a second communication device. The first communication device includes a first receiver, a message processor, and a first transmitter. The first receiver is configured to receive first signals corresponding to a first number of communication devices, where the second communication device is one of the communication devices, and is also configured to measure first strengths of the first signals. The message processor is configured to determine that a second number of the communication devices can be processed by the first communication device according to the first strengths measured. The first transmitter is configured to transmit one or more first messages to the second communication device indicating the second number.

    Abstract translation: 无线耦合到第二通信设备的第一通信设备。 第一通信设备包括第一接收机,消息处理器和第一发射机。 第一接收器被配置为接收对应于第一数量的通信设备的第一信号,其中第二通信设备是通信设备之一,并且还被配置为测量第一信号的第一强度。 消息处理器被配置为根据测量的第一强度来确定第一通信设备可以处理第二数量的通信设备。 第一发射机被配置为向第二通信设备发送指示第二号码的一个或多个第一消息。

    Downlink silent period for positioning
    33.
    发明授权
    Downlink silent period for positioning 有权
    下行静默期定位

    公开(公告)号:US08447323B2

    公开(公告)日:2013-05-21

    申请号:US12554661

    申请日:2009-09-04

    Applicant: Shu Wang

    Inventor: Shu Wang

    CPC classification number: G01S5/14 H04W64/00

    Abstract: A method for acquiring positioning information includes receiving, at a mobile terminal (MT), downlink data in a plurality of downlink slot frames from a serving base station transmitting the downlink data over a first time period generally corresponding to the plurality of downlink slot frames. The MT experiences a relatively silent period during which the serving base station substantially ceases transmission to the mobile terminal during a second time period that defines a transmission power modification period. The MT also receives a preamble broadcasted by various neighbor base stations, the preamble broadcasted by such base stations occurring during a third time period which at least partially overlaps the second time period. The location or position estimate of the MT can be calculated based upon at least the preamble broadcasted by the neighbor base stations.

    Abstract translation: 一种用于获取定位信息的方法包括:在移动终端(MT)处,在通常对应于所述多个下行链路时隙帧的第一时间段内,从在服务基站发送下行链路数据的多个下行链路时隙帧中接收下行链路数据。 在经历相对静止的时段期间,服务基站在定义发射功率修改周期的第二时间段期间基本上停止向移动终端的传输。 MT还接收由各种相邻基站广播的前导码,由第三时间段内发生的由这些基站广播的前导码,其在第二时间段内至少部分地重叠。 可以基于至少由相邻基站广播的前导码来计算MT的位置或位置估计。

    Wireless high-date rate communications
    35.
    发明授权
    Wireless high-date rate communications 有权
    无线高速率通信

    公开(公告)号:US08295251B2

    公开(公告)日:2012-10-23

    申请号:US12626767

    申请日:2009-11-27

    CPC classification number: H04L1/0025 H04L1/0017

    Abstract: A base station apparatus is provided. The base station apparatus includes an orthogonal frequency division multiplexed (OFDM) encoder and a time division multiplexer. The OFDM encoder is configured to encode a plurality of data streams into a corresponding plurality of OFDM tones, where one of the corresponding plurality of OFDM tones includes an OFDM preamble tone that indicates a mapping of remaining OFDM tones within the plurality of OFDM tones to one or more of a plurality of mobile stations, and indicates at least one of the plurality of tones addressed to a particular mobile device, and wherein the preamble tone is not fixed to the selected particular mobile device through communication. multiplexes a plurality of streams over a forward link channel for receipt by the plurality of mobile stations, where the corresponding plurality of OFDM tones are encoded as one of the plurality of streams.

    Abstract translation: 提供了一种基站装置。 基站装置包括正交频分复用(OFDM)编码器和时分多路复用器。 OFDM编码器被配置为将多个数据流编码为对应的多个OFDM音调,其中相应的多个OFDM音调中的一个OFDM音调包括OFDM前导码音调,其指示在多个OFDM音调内的剩余OFDM音调到一个 多个移动站中的至少一个,并且指示寻址到特定移动设备的多个音调中的至少一个,并且其中前导码音调并不通过通信固定到所选择的特定移动设备。 在前向链路信道上复用多个流,以便由多个移动站接收,其中对应的多个OFDM音调被编码为多个流中的一个。

    Code combining soft handoff in wireless communication system
    36.
    发明授权
    Code combining soft handoff in wireless communication system 有权
    无线通信系统中的软切换代码组合

    公开(公告)号:US08261168B2

    公开(公告)日:2012-09-04

    申请号:US12211763

    申请日:2008-09-16

    CPC classification number: H04L1/0069 H04L1/0066 H04L1/007 H04L1/06 H04W36/18

    Abstract: The present invention relates to a method for transmitting a signal in a wireless communication system. The method includes channel coding a data stream using a first turbo encoded puncture pattern, and channel coding the data stream using a second turbo encoded puncture pattern. Preferably, the first turbo encoded puncture pattern is a turbo encoded puncture pattern of a first local operator infrastructure (LOI) and the second turbo encoded puncture pattern is a turbo encoded puncture pattern of a second LOI that neighbors the first LOI.

    Abstract translation: 本发明涉及一种在无线通信系统中发送信号的方法。 该方法包括使用第一turbo编码穿孔模式对数据流进行信道编码,以及使用第二turbo编码穿孔模式对数据流进行信道编码。 优选地,第一turbo编码穿刺模式是第一本地运营商基础设施(LOI)的turbo编码穿孔模式,并且第二turbo编码穿孔模式是与第一LOI相邻的第二LOI的turbo编码穿孔模式。

    Method and apparatus for power management in handover between heterogeneous networks
    37.
    发明授权
    Method and apparatus for power management in handover between heterogeneous networks 有权
    异构网络之间切换中的电源管理方法和装置

    公开(公告)号:US08254337B2

    公开(公告)日:2012-08-28

    申请号:US12133840

    申请日:2008-06-05

    Abstract: A method for power management in handover between heterogeneous networks comprising: an MIH layer obtains power information and provides it for an MIH user layer; the MIH user layer determines the handover policy according to the power information. In various embodiments of the disclosure, the MIH layer triggers an event so that the MIH user layer can obtain power information, and select a lower-layer network connection automatically according to the current power status, thus implementing handover; the MIH user layer sends a query request to the MIH layer to obtain power consumption parameters from the network, and selects a lower-layer network connection according to the power consumption and the current power status, thus implementing handover and making more accurate and effective decisions in the handover.

    Abstract translation: 一种用于在异构网络之间的切换中的功率管理的方法,包括:MIH层获得功率信息并将其提供给MIH用户层; MIH用户层根据功率信息确定切换策略。 在本公开的各种实施例中,MIH层触发事件,使得MIH用户层可以获取功率信息,并根据当前的电源状态自动选择下层网络连接,从而实现切换; MIH用户层向MIH层发送查询请求以从网络获取功耗参数,并根据功耗和当前功率状态选择下层网络连接,从而实现切换并做出更准确有效的决策 在交接中。

    Access probe enhancements
    38.
    发明授权
    Access probe enhancements 有权
    访问探测增强功能

    公开(公告)号:US08180378B2

    公开(公告)日:2012-05-15

    申请号:US12464789

    申请日:2009-05-12

    CPC classification number: H04W64/00 H04W64/003

    Abstract: A method of providing a location based service to an access terminal in a mobile communication system is provided. The method includes transmitting one or more access probes, each of the one or more access probes including a preamble having a first specific length and transmitted at a first power level, where the preamble is utilized to determine a position of the access terminal.

    Abstract translation: 提供了一种向移动通信系统中的接入终端提供基于位置的服务的方法。 该方法包括发送一个或多个接入探测器,所述一个或多个接入探测器中的每一个包括具有第一特定长度并以第一功率电平发射的前同步码,其中前导码用于确定接入终端的位置。

    ENHANCED WIRELESS COMMUNICATION WITH HARQ
    40.
    发明申请
    ENHANCED WIRELESS COMMUNICATION WITH HARQ 有权
    具有HARQ的增强无线通信

    公开(公告)号:US20110264976A1

    公开(公告)日:2011-10-27

    申请号:US13088868

    申请日:2011-04-18

    CPC classification number: H04L1/1887 H04L1/188

    Abstract: A wireless communication system including a receiver and a transmitter. The receiver receives a frame of data, and sends an acknowledgement. The acknowledgement includes a positive acknowledgement (ACK) if the data is successfully decoded or a negative acknowledgement (NAK) if the data is unsuccessfully decoded. The acknowledgement is sent according to timing of an acknowledge mask. The transmitter is wirelessly coupled to the receiver, and receives the acknowledgement according to the acknowledge mask, and sends a response to the receiver according to the acknowledgement. The response includes, if an ACK is received before transmission completes of the frame, the transmitter terminates transmission of the frame; if a NAK is received before transmission completes of the frame, the transmitter continues to send the frame; and if an ACK is not received before a predefined frame early scheduling point, the transmitter retransmits the frame after transmission completes of the frame.

    Abstract translation: 一种包括接收机和发射机的无线通信系统。 接收器接收一帧数据,并发送确认。 如果数据被成功解码,则该确认包括肯定确认(ACK),或者如果数据未成功解码则包括否定确认(NAK)。 确认是根据确认掩码的定时发送的。 发射机无线耦合到接收机,并根据确认掩码接收确认,并根据确认向接收机发送响应。 响应包括:如果在帧的传输完成之前接收到ACK,则发射机终止帧的传输; 如果在帧的传输完成之前接收到NAK,则发射机继续发送帧; 并且如果在预定义帧提前调度点之前没有接收到ACK,则发射机在帧的传输完成之后重发帧。

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