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76 条记录 (耗时 0.04 秒)

    Antibodies to &agr;v&bgr;3 integrin
    32.
    发明授权
    Antibodies to &agr;v&bgr;3 integrin 失效
    抗体为alphavbeta3整合素

    公开(公告)号：US06369204B1

    公开(公告)日：2002-04-09

    申请号：US09560743

    申请日：2000-04-28

    申请人： Kyung Jin Kim ,  Michael A. Horton ,  Sarah C. Bodary ,  Anan Chuntharapai

    发明人： Kyung Jin Kim ,  Michael A. Horton ,  Sarah C. Bodary ,  Anan Chuntharapai

    IPC分类号： C12P2108

    CPC分类号： C07K16/2848 ,  A61K38/00 ,  Y10S530/867

    摘要： The invention relates to monoclonal antibodies to the &agr;v&bgr;3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies are believed to recognize unique epitopes on &agr;v&bgr;3 and are useful in the treatment of conditions associated with excessive bone resorption and/or in the inhibition of tumor cell growth.

    摘要翻译： 本发明涉及已知在破骨细胞表面上大量表达的α受体α整联蛋白受体的单克隆抗体，因此与骨吸收有关。 据信所公开的单克隆抗体识别出在α2β3上的独特表位，并且可用于治疗与过量骨吸收和/或抑制肿瘤细胞生长相关的病症。

    Apo-2 ligand
    33.
    发明授权
    Apo-2 ligand 失效
    Apo-2配体抗体

    公开(公告)号：US6046048A

    公开(公告)日：2000-04-04

    申请号：US780496

    申请日：1997-01-08

    申请人： Avi J. Ashkenazi ,  Anan Chuntharapai ,  Kyung Jin Kim

    发明人： Avi J. Ashkenazi ,  Anan Chuntharapai ,  Kyung Jin Kim

    IPC分类号： C07K14/705 ,  C07K16/28 ,  C12N5/16

    CPC分类号： C07K14/70575 ,  C07K16/2875 ,  C07K2317/34

    摘要： A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.

    摘要翻译： 提供了诱导哺乳动物细胞凋亡的新型细胞因子，称为Apo-2配体。 Apo-2配体被认为是TNF细胞因子家族的成员。 还提供了包括Apo-2配体嵌合体，编码Apo-2配体的核酸和Apo-2配体的抗体的组合物。 进一步提供了使用Apo-2配体诱导细胞凋亡和治疗病理状况如癌症的方法。

    Monoclonal antibodies to human leukemia inhibitory factor
    34.
    发明授权
    Monoclonal antibodies to human leukemia inhibitory factor 失效
    人白血病抑制因子单克隆抗体

    公开(公告)号：US5688681A

    公开(公告)日：1997-11-18

    申请号：US258918

    申请日：1994-06-13

    申请人： Kyung Jin Kim

    发明人： Kyung Jin Kim

    IPC分类号： A61K38/00 ,  C07K16/24 ,  C12P21/08 ,  C12N5/20 ,  G01N33/53

    CPC分类号： C07K16/244 ,  A61K38/00 ,  C07K2317/74

    摘要： The invention relates to monoclonal antibodies to human leukemia inhibitory factor. The disclosed monoclonal antibodies are believed to recognize unique epitopes on hLIF and are useful in the treatment of conditions wherein the presence of hLIF causes or contributes to undesirable pathological effects, such as cachexia, dysregulated calcium metabolism, or excessive bone cell proliferation, and in the detection of hLIF, for example, in clinical samples or specimens.

    摘要翻译： 本发明涉及人白血病抑制因子的单克隆抗体。 所公开的单克隆抗体被认为在hLIF上识别出独特的表位，并且可用于治疗其中hLIF的存在引起或有助于不期望的病理学作用，例如恶病质，调节钙代谢或过度骨细胞增殖的病症，并且在 检测hLIF，例如临床样本或标本。