Antibodies to &agr;v&bgr;3 integrin
    3.
    发明授权
    Antibodies to &agr;v&bgr;3 integrin 失效
    抗体为alphavbeta3整合素

    公开(公告)号:US06359126B1

    公开(公告)日:2002-03-19

    申请号:US08874837

    申请日:1997-06-13

    IPC分类号: C07H2104

    摘要: The invention relates to monoclonal antibodies to the &agr;v&bgr;3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies recognize unique epitopes on &agr;v&bgr;3 and are useful in the treatment of conditions associated with excessive bone resorption and/or in the inhibition of tumor cell growth.

    摘要翻译: 本发明涉及已知在破骨细胞表面上大量表达的α受体α整联蛋白受体的单克隆抗体,因此与骨吸收有关。 所公开的单克隆抗体识别出在alphavbeta3上的独特表位,并且可用于治疗与过量骨吸收和/或抑制肿瘤细胞生长相关的病症。