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31.发明申请CHARACTERIZATION OF THE CBIR1 ANTIGENIC RESPONSE FOR DIAGNOSIS AND TREATMENT OF CROHN'S DISEASE 审中-公开CBIR1抗原反应诊断和治疗高血糖病的特征公开(公告)号：US20130058953A1
公开(公告)日：2013-03-07
申请号：US13410881
申请日：2012-03-02
IPC分类号： C12Q1/68 , C40B30/04 , G01N33/566 , A61K39/40 , A61P1/00
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： This invention provides methods of diagnosing or predicting susceptibility to Crohn's Disease by determining the presence or absence of genetic variants. In one embodiment, the present invention provides methods to diagnose and/or predict susceptibility to Crohn's Disease in an individual by determining the presence or absence of anti-Cbir1 reactivity and the presence or absence of TLR5 risk variants. In another embodiment, the present invention provides methods to diagnose Crohn's Disease by determining the presence or absence of NFKB1 haplotype H3 and/or ASCA expression. In another embodiment, the present invention provides methods of diagnosing Crohn's Disease by determining the presence or absence of Cbir1 specific peripheral blood T cell proliferation.
摘要翻译： 本发明通过确定遗传变异体的存在或不存在来提供诊断或预测克罗恩病敏感性的方法。 在一个实施方案中，本发明提供了通过确定抗Cbir1反应性的存在或不存在以及是否存在TLR5风险变体来诊断和/或预测个体中克罗恩病易感性的方法。 在另一个实施方案中，本发明通过确定NFκB1单倍型H3和/或ASCA表达的存在或不存在来提供诊断克罗恩病的方法。 在另一个实施方案中，本发明通过确定Cbir1特异性外周血T细胞增殖的存在或不存在来提供诊断克罗恩病的方法。
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公开(公告)号：US20120208900A1
公开(公告)日：2012-08-16
申请号：US13372359
申请日：2012-02-13
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156
摘要： The present invention relates to methods of predicting susceptibility to a severe form of Crohn's disease in an individual by determining the presence or absence of one or more risk variants. In one embodiment, the risk variants comprise a combination of genetic risk variants and clinical risk factors. In another embodiment, the genetic risk variants are at the IL12B genetic locus. In another embodiment, the severe form of Crohn's disease is characterized by a rapid progression to a condition requiring surgery for treatment.
摘要翻译： 本发明涉及通过确定一种或多种风险变体的存在或不存在来预测个体中严重形式的克罗恩病易感性的方法。 在一个实施方案中，风险变体包括遗传风险变体和临床危险因素的组合。 在另一个实施方案中，遗传风险变体位于IL12B遗传基因座。 在另一个实施方案中，克罗恩病的严重形式的特征在于快速进展到需要手术治疗的病症。
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公开(公告)号：US20120073585A1
公开(公告)日：2012-03-29
申请号：US13263707
申请日：2010-04-08
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156
摘要： The present invention relates to prognosing, diagnosing and treating an aggressive form of Crohn's disease characterized by rapid progression to complication and/or surgery from the time of diagnosis. In one embodiment, the prognosis, diagnosis and treatment is based upon the presence of one or more genetic risk factors.
摘要翻译： 本发明涉及预测，诊断和治疗克罗恩病的攻击性形式，其特征在于从诊断时快速进展为并发症和/或手术。 在一个实施方案中，预后，诊断和治疗是基于一种或多种遗传危险因素的存在。
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34.发明申请DIAGNOSIS AND TREATMENT OF INFLAMMATORY BOWEL DISEASE IN THE PUERTO RICAN POPULATION 审中-公开在波多黎各人口中诊断和治疗炎症性皮肤病公开(公告)号：US20100184050A1
公开(公告)日：2010-07-22
申请号：US12597710
申请日：2008-04-25
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： This invention provides methods of diagnosis and treatment of inflammatory bowel disease. In one embodiment, the invention provides methods of diagnosing and/or predicting susceptibility for inflammatory bowel disease in the Puerto Rican population by determining the presence or absence of a risk variant at the HPS1 locus. In another embodiment, the invention further provides methods of diagnosing and/or predicting protection against inflammatory bowel disease by determining the presence or absence of a protective variant at the IRF1 locus. In another embodiment, the presence in an individual of a risk variant at the CARD8 locus is diagnostic of susceptibility to Crohn's Disease in a Puerto Rican individual. In another embodiment, the presence of a risk variant at the TLR-9 locus in an individual is diagnostic of susceptibility to Crohn's Disease.
摘要翻译： 本发明提供了炎症性肠病的诊断和治疗方法。 在一个实施方案中，本发明通过确定在HPS1基因座处存在或不存在风险变体来提供在波多黎各人群中诊断和/或预测炎症性肠病易感性的方法。 在另一个实施方案中，本发明进一步提供了通过确定IRF1基因座处存在或不存在保护性变体来诊断和/或预测抗炎性肠病的方法。 在另一个实施方案中，在CARD8基因座上个体存在风险变异体的诊断是波多黎各个体对克罗恩病易感性的诊断。 在另一个实施方案中，个体中TLR-9位点处的风险变体的存在是对克罗恩病易感性的诊断。
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公开(公告)号：US20100144903A1
公开(公告)日：2010-06-10
申请号：US12598794
申请日：2008-05-02
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： In one embodiment, this invention provides methods of diagnosing and/or predicting susceptibility to Crohn's Disease by determining the presence or absence of risk haplotypes in IL23R, IL17A, IL17RA and/or IL12RB1 locus. In another embodiment, the invention provides methods of diagnosing and/or predicting susceptibility to Crohn's Disease in an individual by determining the presence or absence of risk haplotype at the IL12RB2 locus.
摘要翻译： 在一个实施方案中，本发明通过确定IL23R，IL17A，IL17RA和/或IL12RB1基因座中风险单倍体的存在或不存在来提供诊断和/或预测克罗恩病易感性的方法。 在另一个实施方案中，本发明提供了通过确定在IL12RB2基因座处存在或不存在风险单倍型来诊断和/或预测个体中克罗恩病易感性的方法。
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公开(公告)号：US09902996B2
公开(公告)日：2018-02-27
申请号：US13372359
申请日：2012-02-13
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156
摘要： The present invention relates to methods of predicting susceptibility to a severe form of Crohn's disease in an individual by determining the presence or absence of one or more risk variants. In one embodiment, the risk variants comprise a combination of genetic risk variants and clinical risk factors. In another embodiment, the genetic risk variants are at the IL12B genetic locus. In another embodiment, the severe form of Crohn's disease is characterized by a rapid progression to a condition requiring surgery for treatment.
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37.发明授权Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy 有权预测需要结肠切除术的医疗屈光性溃疡性结肠炎（MR-UC）的方法公开(公告)号：US09580752B2
公开(公告)日：2017-02-28
申请号：US13140874
申请日：2009-12-24
申请人： Jerome I. Rotter , Kent D. Taylor , Stephan R. Targan , Talin Haritunians , Dermot P. McGovern , Xiuqing Guo
发明人： Jerome I. Rotter , Kent D. Taylor , Stephan R. Targan , Talin Haritunians , Dermot P. McGovern , Xiuqing Guo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , G01N2800/067
摘要： Disclosed are methods of predicting the development of medically refractory ulcerative colitis (MR-UC) in a patient In one embodiment, disclosed is a method of prognosing ulcerative colitis in an individual by determining the presence or absence of one or more risk variants, where the presence of one or more risk variants is indicative of a severe and/or aggressive form of ulcerative colitis. In another embodiment, the severe form of ulcerative colitis is indicative of MR-UC.
摘要翻译： 公开了预测患者中医学难治性溃疡性结肠炎（MR-UC）的发展的方法。在一个实施方案中，公开了通过确定一种或多种风险变异体的存在或不存在来预测个体中溃疡性结肠炎的方法，其中 一种或多种风险变体的存在表示严重和/或侵略性形式的溃疡性结肠炎。 在另一个实施方案中，严重形式的溃疡性结肠炎指示MR-UC。
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38.发明申请METHODS OF USING SINGLE NUCLEOTIDE POLYMORPHISMS IN THE TL1A GENE TO PREDICT OR DIAGNOSE INFLAMMATORY BOWEL DISEASE 审中-公开使用单核苷酸多态性在TL1A基因中预测或诊断炎症性皮肤病的方法公开(公告)号：US20100190162A1
公开(公告)日：2010-07-29
申请号：US12528055
申请日：2008-02-26
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C07K16/2875 , C07K2317/76 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6893 , G01N2800/065 , G01N2800/50
摘要： This invention provides methods of diagnosing or predicting susceptibility to Inflammatory Bowel Disease by determining the presence or absence of genetic variants in the TL1A gene. In one embodiment, a method of the invention is practiced by determining the presence or absence of TL1A production following Fc-gamma-R activation. In another embodiment, the invention provides methods of treatment of inflammatory bowel disease by inhibition of TL1A.
摘要翻译： 本发明提供通过确定TL1A基因中遗传变异体的存在或不存在来诊断或预测对炎症性肠病易感性的方法。 在一个实施方案中，通过测定Fc-γ-R活化后TL1A产生的存在或不存在来实施本发明的方法。 在另一个实施方案中，本发明提供通过抑制TL1A治疗炎性肠病的方法。
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39.发明申请METHODS OF USING GENES AND GENETIC VARIANTS TO PREDICT OR DIAGNOSE INFLAMMATORY BOWEL DISEASE 审中-公开使用基因和遗传变异体预测或诊断炎症性皮肤疾病的方法公开(公告)号：US20100021917A1
公开(公告)日：2010-01-28
申请号：US12527376
申请日：2008-02-14
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/172
摘要： This invention provides methods of diagnosing or predicting susceptibility to inflammatory bowel disease by determining the presence or absence of genetic variants. In one embodiment, a the invention is practiced by determining the presence or absence of NOD2 variants in an individual where the presence of NOD2 variants are indicative of susceptibility to Crohn's Disease in the individual. In another embodiment, the invention further determines the presence or absence of TLR8 variants where the presence of TLR8 variants are inflammatory bowel disease in female individuals. In another embodiment, the invention further determines the presence or absence of TR2 variant P631H where the presence of TLR2 variant P631H is indicative of susceptibility to Crohn's Disease.
摘要翻译： 本发明提供通过确定遗传变异体的存在或不存在来诊断或预测对炎症性肠病易感性的方法。 在一个实施方案中，本发明通过确定个体中NOD2变体的存在或不存在来实施，其中NOD2变体的存在指示个体对克罗恩病的易感性。 在另一个实施方案中，本发明进一步确定TLR8变体的存在或不存在，其中TLR8变体的存在是女性个体中的炎症性肠病。 在另一个实施方案中，本发明还确定TR2变体P631H的存在或不存在，其中TLR2变体P631H的存在表示对克罗恩病的易感性。
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公开(公告)号：US07037651B2
公开(公告)日：2006-05-02
申请号：US09909317
申请日：2001-07-18
申请人： Betty P. Tsao , Rita M. Cantor , Jerome I. Rotter
发明人： Betty P. Tsao , Rita M. Cantor , Jerome I. Rotter
CPC分类号： C12Q1/6883 , C12Q2600/156 , Y10S435/81
摘要： Disclosed is a genetic testing method for diagnosing systemic lupus erythematosus (SLE) in a human subject. The method is related to amplifying nucleic acids from human tissue samples and detecting the presence or absence of variant alleles of a gene encoding poly(ADP-ribosyl)transferase expression (PARP), which are diagnostic of SLE or indicate a genetic predisposition for developing SLE. Also disclosed are useful oligonucleotide primers, primer sets and genetic testing kits for detecting a genetic predisposition for developing SLE.
摘要翻译： 公开了用于诊断人类受试者的系统性红斑狼疮（SLE）的遗传检测方法。 该方法涉及从人组织样品中扩增核酸并检测编码聚（ADP-核糖基）转移酶表达（PARP）的基因的变异等位基因的存在或不存在，其是SLE诊断或指示用于发展SLE的遗传倾向 。 还公开了用于检测发展SLE的遗传易感性的有用的寡核苷酸引物，引物组和遗传检测试剂盒。
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