公开(公告)号：US20170315133A1

公开(公告)日：2017-11-02

申请号：US15581626

申请日：2017-04-28

申请人： J. Steven ALEXANDER ,  Ikuo TSUNODA ,  Urska CVEK ,  J. Winny YUN ,  Alireza MINAGAR

发明人： J. Steven ALEXANDER ,  Ikuo TSUNODA ,  Urska CVEK ,  J. Winny YUN ,  Alireza MINAGAR

IPC分类号： G01N33/68 ,  G01N33/564 ,  G01N33/53 ,  A61K39/00

CPC分类号： G01N33/6896 ,  G01N33/6893 ,  G01N2800/04 ,  G01N2800/065 ,  G01N2800/067 ,  G01N2800/104 ,  G01N2800/105 ,  G01N2800/24 ,  G01N2800/245 ,  G01N2800/2821 ,  G01N2800/285 ,  G01N2800/7085

摘要： The presently claimed invention relates to materials and methods for diagnosing a chronic inflammatory disease in a patient comprising testing a biological sample from the patient for a level of a first neurovascular biomarker of lymphatic activation and diagnosing the patient as having the chronic inflammatory disease if the tested level of the first neurovascular biomarker of lymphatic activation is less than a first normal level.

公开(公告)号：US20170129946A1

公开(公告)日：2017-05-11

申请号：US15002688

申请日：2016-01-21

申请人： THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

发明人： KEVIN J. TRACEY ,  HAICHAO WANG

IPC分类号： C07K16/18 ,  C07K16/24 ,  C07K16/28 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K39/395 ,  A61K39/39533 ,  A61K2039/505 ,  C07K16/24 ,  C07K16/241 ,  C07K16/2866 ,  C07K2317/70 ,  C07K2317/76 ,  G01N33/6875 ,  G01N2800/065 ,  G01N2800/067 ,  G01N2800/125 ,  G01N2800/245 ,  G01N2800/26 ,  Y02A50/412 ,  A61K2300/00

摘要： There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method for monitoring the severity or potential lethality of sepsis or septic shock, comprising measuring the serum concentration of HMG1 in a patient exhibiting or at risk of exhibiting sepsis or septic shock symptoms. Lastly, there is disclosed a pharmaceutical composition and method for effecting weight loss or treating obesity, comprising administering an effective amount of HMG1 or a therapeutically active HMG1 fragment.

公开(公告)号：US09580752B2

公开(公告)日：2017-02-28

申请号：US13140874

申请日：2009-12-24

申请人： Jerome I. Rotter ,  Kent D. Taylor ,  Stephan R. Targan ,  Talin Haritunians ,  Dermot P. McGovern ,  Xiuqing Guo

发明人： Jerome I. Rotter ,  Kent D. Taylor ,  Stephan R. Targan ,  Talin Haritunians ,  Dermot P. McGovern ,  Xiuqing Guo

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156 ,  G01N2800/067

摘要： Disclosed are methods of predicting the development of medically refractory ulcerative colitis (MR-UC) in a patient In one embodiment, disclosed is a method of prognosing ulcerative colitis in an individual by determining the presence or absence of one or more risk variants, where the presence of one or more risk variants is indicative of a severe and/or aggressive form of ulcerative colitis. In another embodiment, the severe form of ulcerative colitis is indicative of MR-UC.

摘要翻译： 公开了预测患者中医学难治性溃疡性结肠炎（MR-UC）的发展的方法。在一个实施方案中，公开了通过确定一种或多种风险变异体的存在或不存在来预测个体中溃疡性结肠炎的方法，其中 一种或多种风险变体的存在表示严重和/或侵略性形式的溃疡性结肠炎。 在另一个实施方案中，严重形式的溃疡性结肠炎指示MR-UC。

公开(公告)号：US20150232485A1

公开(公告)日：2015-08-20

申请号：US14414916

申请日：2013-07-16

申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.

发明人： David Margulies ,  Bhimsen Rout

IPC分类号： C07F5/02 ,  C09B62/44 ,  G01N33/58

CPC分类号： C07F5/025 ,  C07D211/60 ,  C09B62/44 ,  G01J3/4406 ,  G01N33/582 ,  G01N2400/00 ,  G01N2458/30 ,  G01N2800/042 ,  G01N2800/065 ,  G01N2800/067 ,  G01N2800/285

摘要： The present invention is directed to a multi-sensor array compound including at least three chromophores, at least one receptor and an anchor. Contacting the compound of this invention with an analyte (such as carbohydrate) forms a complex with unique optical signature. The unique optical signature allows differentiating between carbohydrates, diagnosing diseases associated with the carbohydrate, and encoding information in an encoding system.

摘要翻译： 本发明涉及包含至少三个发色团，至少一个受体和锚的多传感器阵列化合物。 将本发明化合物与分析物（例如碳水化合物）接触形成具有独特光学特征的复合物。 独特的光学特征允许区分碳水化合物，诊断与碳水化合物相关的疾病，以及编码系统中的编码信息。

公开(公告)号：US20150126622A1

公开(公告)日：2015-05-07

申请号：US14406098

申请日：2013-06-10

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Karl G. Sylvester ,  Guozhong Tao

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/515 ,  G01N2333/75 ,  G01N2333/91085 ,  G01N2800/067 ,  G01N2800/52

摘要： Necrotizing Enterocolitis (NEC) biomarkers, NEC biomarker panels, and methods for obtaining a NEC signature for a sample are provided. Also provided are methods, compositions, and kits for making a Necrotizing Enterocolitis (NEC) assessment of an individual, e.g. for diagnosing NEC in a patient, prognosing NEC in a patient, treating an NEC patient, etc. These methods find use in a number of applications, such as diagnosing and treating infants who are suspected of having NEC, intestinal perforation (IP), or sepsis.

摘要翻译： 提供坏死性小肠结肠炎（NEC）生物标志物，NEC生物标志物组和用于获得样品的NEC标记的方法。 还提供了用于制备个体坏死性小肠结肠炎（NEC）评估的方法，组合物和试剂盒，例如， 用于诊断患者中的NEC，预测患者中的NEC，治疗NEC患者等。这些方法可用于多种应用，例如诊断和治疗怀疑患有NEC，肠穿孔（IP）或 败血症

公开(公告)号：US20140335543A1

公开(公告)日：2014-11-13

申请号：US14205995

申请日：2014-03-12

申请人： 3M Innovative Properties Company

发明人： RAJ RAJAGOPAL ,  AI-PING WEI

IPC分类号： G01N33/569

CPC分类号： G01N33/56911 ,  C07K16/1282 ,  C07K16/40 ,  G01N2333/33 ,  G01N2469/10 ,  G01N2800/067

摘要： The present invention provides antibodies that bind to the endospore of the bacterium Clostridium difficile, methods of making such antibodies, and methods of using such antibodies, including methods of detecting C. difficile endospores.

摘要翻译： 本发明提供了结合细菌艰难梭菌的内生孢子的抗体，制备这种抗体的方法，以及使用这些抗体的方法，包括检测艰难梭菌内切孢子的方法。

公开(公告)号：US20140140970A1

公开(公告)日：2014-05-22

申请号：US14044328

申请日：2013-10-02

申请人： Children's Hospital Medical Center

发明人： Ardythe L. Morrow ,  David S. Newburg ,  Guillermo M. Ruiz-Palacios

IPC分类号： A61K31/715 ,  A61K36/06 ,  A61K31/702 ,  A61K35/74

CPC分类号： A61K31/7028 ,  A61K31/702 ,  A61K31/715 ,  A61K35/741 ,  A61K35/745 ,  A61K35/747 ,  A61K36/06 ,  A61K38/02 ,  A61K45/06 ,  G01N33/6893 ,  G01N33/80 ,  G01N2800/067 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/491 ,  Y02A50/52

摘要： An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).

摘要翻译： 可以通过测量来自个体的生物样品中的至少一种分泌型抗原的水平来鉴定坏死性小肠结肠炎和相关疾病风险的个体，并将所测量的至少一种分泌型抗原的水平与预定值或预定范围进行比较 的价值观。 可以测量的分泌抗原是：H-1，H-2，Lewisb和Lewisy抗原及其衍生物（例如，路易斯a的唾液酸化形式，Lewis x，Lewis b，Lewis y; H-1，H -2，Lewis a，Lewis x，Lewis b或Lewis y）。

公开(公告)号：US08617551B2

公开(公告)日：2013-12-31

申请号：US12854005

申请日：2010-08-10

申请人： Roger T. Coleman ,  Olga Bandman ,  Craig G. Wilde

发明人： Roger T. Coleman ,  Olga Bandman ,  Craig G. Wilde

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/24 ,  C07K16/00

CPC分类号： C07K16/24 ,  A61K38/00 ,  C07K1/22 ,  C07K14/523 ,  C12Q1/68 ,  C12Q2600/118 ,  G01N33/6863 ,  G01N33/6893 ,  G01N2800/067

摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (PANEC-1 and PANEC-2) from human pancreas cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode PANEC-1 and PANEC-2, expression vectors for the production of purified PANEC-1 and PANEC-2, antibodies capable of binding specifically to PANEC-1 and PANEC-2, hybridization probes or oligonucleotides for the detection of PANEC-1- or PANEC-2-encoding nucleotide sequences, genetically engineered host cells for the expression of PANEC-1 and PANEC-2, diagnostic tests for chemokine activation based on PANEC-1- and PANEC-2-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.

摘要翻译： 本发明提供鉴定和编码来自人胰腺细胞的新型表达趋化因子（PANEC-1和PANEC-2）的核苷酸和氨基酸序列。 本发明还提供编码PANEC-1和PANEC-2的核苷酸序列的反义分子，用于产生纯化的PANEC-1和PANEC-2的表达载体，能够特异性结合PANEC-1和PANEC-2的抗体 ，用于检测PANEC-1或PANEC-2编码核苷酸序列的杂交探针或寡核苷酸，用于表达PANEC-1和PANEC-2的遗传工程改造的宿主细胞，基于PANEC-1的趋化因子激活的诊断试验和 编码PANEC-2的核酸分子和能够特异性结合蛋白质的抗体。

公开(公告)号：US08314061B2

公开(公告)日：2012-11-20

申请号：US12160335

申请日：2007-01-09

申请人： Ardythe L. Morrow ,  Lisa J. Martin ,  David S. Newburg

发明人： Ardythe L. Morrow ,  Lisa J. Martin ,  David S. Newburg

IPC分类号： C07K14/00

CPC分类号： A61K38/2264 ,  A23L33/19 ,  A23L33/40 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/065 ,  G01N2800/067 ,  G01N2800/32 ,  G01N2800/321 ,  G01N2800/323 ,  G01N2800/324 ,  A61K2300/00

摘要： Methods for treating various disorders by orally administering adiponectin or a biologically active fragment thereof are described.

摘要翻译： 描述了通过口服施用脂联素或其生物活性片段治疗各种疾病的方法。

公开(公告)号：US08058019B2

公开(公告)日：2011-11-15

申请号：US12523997

申请日：2008-01-28

申请人： Dirk Roggenbuck

发明人： Dirk Roggenbuck

IPC分类号： G01N33/53

CPC分类号： C07K14/4733 ,  A61K35/16 ,  A61K38/00 ,  A61K38/1709 ,  B01D15/00 ,  B01D15/3809 ,  B01J20/3242 ,  G01N33/564 ,  G01N2800/065 ,  G01N2800/067

摘要： The invention relates to a method for the detection of antibodies from body fluids via immune reaction with GP2 from pancreatic zymogenic granules, immunoreactive sequences or analogs thereof, excluding tissue sections.

摘要翻译： 本发明涉及一种通过与GP2的免疫反应从体液中检测抗体的方法，所述免疫反应来自胰酶发酵颗粒，免疫反应性序列或其类似物，不包括组织切片。