公开(公告)号：US5869632A

公开(公告)日：1999-02-09

申请号：US465976

申请日：1995-06-06

申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C07K14/72 ,  C07K14/705 ,  A61K38/00

摘要： A human G-protein receptor HCEGH45 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat PACAP hypersecretory conditions and to create pharmacological amnesia models while the agonists may be employed to treat amnesia and Alzheimer's disease. Also disclosed are diagnostic methods for detecting a mutation in the receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

摘要翻译： 公开了人类G蛋白受体HCEGH45多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽鉴定这种多肽的拮抗剂和激动剂的方法。 针对这种多肽的拮抗剂可以用于治疗PACAP过度分泌病症并产生药理学遗忘症模型，同时激动剂可用于治疗遗忘症和阿尔茨海默氏病。 还公开了用于检测受体核酸序列中的突变并检测衍生自宿主的样品中可溶形式的受体的诊断方法。

公开(公告)号：US5756309A

公开(公告)日：1998-05-26

申请号：US465980

申请日：1995-06-06

申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  C07H21/00

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026 ,  C12N2799/027

摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

摘要翻译： 公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及在治疗性地使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过度表达相关的病症的方法。 还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

公开(公告)号：US20080312178A1

公开(公告)日：2008-12-18

申请号：US12182466

申请日：2008-07-30

申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

IPC分类号： A61K38/02 ,  C07H21/04 ,  C12P21/00 ,  C12N5/06 ,  C12N1/21 ,  C12N1/15 ,  C07K2/00 ,  C07K16/00 ,  A61K31/7088 ,  G01N33/566 ,  A61P35/00

CPC分类号： C07K14/7158 ,  A61K38/00 ,  C07K14/723

摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

摘要翻译： 公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

公开(公告)号：US06824993B2

公开(公告)日：2004-11-30

申请号：US09968033

申请日：2001-10-02

申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

IPC分类号： C07K1618

CPC分类号： C07K16/28 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K2317/622

摘要： The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer. The invention further relates to screening methods for identifying agonists and antagonists of PSGR polynucleotides and polypeptides of the invention and methods and/or compositions for inhibiting or enhancing the production and/or function of the PSGR polypeptides of the present invention.

摘要翻译： 本发明涉及PSGR，一种与在前列腺癌中过表达的G蛋白偶联受体具有同源性的新型前列腺特异性基因。 更具体地，本发明涉及PSGR多核苷酸和由这些多核苷酸编码的多肽，以及使用PSGR多核苷酸和多肽来检测生殖系统疾病，包括前列腺疾病，特别是癌症的存在。 本发明涉及PSGR多核苷酸和多肽以及载体，宿主细胞，针对PSGR多核苷酸和多肽的抗体以及用于制备它的重组和合成方法。 还提供了用于诊断，治疗，预防和/或预后与前列腺相关的疾病（包括癌症）的方法。 本发明还涉及用于鉴定本发明的PSGR多核苷酸和多肽的激动剂和拮抗剂的筛选方法以及用于抑制或增强本发明的PSGR多肽的产生和/或功能的方法和/或组合物。

公开(公告)号：US5948890A

公开(公告)日：1999-09-07

申请号：US53303

申请日：1998-04-01

申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

IPC分类号： C07K14/705 ,  C07K16/28

CPC分类号： C07K16/28 ,  A61K2039/505

摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

公开(公告)号：US20110112177A1

公开(公告)日：2011-05-12

申请号：US12943202

申请日：2010-11-10

申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

IPC分类号： A61K31/7052 ,  C07H21/00 ,  C12N15/63 ,  C12N1/00 ,  C12N5/00 ,  C12P21/00 ,  C12N15/74 ,  C07K14/435 ,  C07K16/18 ,  G01N33/53 ,  C12Q1/68 ,  A61P9/12 ,  A61P9/10 ,  A61P25/00

CPC分类号： C07K14/705

摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

摘要翻译： 公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

公开(公告)号：US5958729A

公开(公告)日：1999-09-28

申请号：US982412

申请日：1997-12-02

申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C12N5/10 ,  C12N15/12

CPC分类号： C07K14/72 ,  C07K14/705 ,  A61K38/00

摘要： A human G-protein receptor HCEGH45 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat PACAP hypersecretory conditions and to create pharmacological amnesia models while the agonists may be employed to treat amnesia and Alzheimer's disease. Also disclosed are diagnostic methods for detecting a mutation in the receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

公开(公告)号：US07393650B2

公开(公告)日：2008-07-01

申请号：US10921218

申请日：2004-08-19

申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

IPC分类号： G01N33/53 ,  C07K16/28 ,  C07K14/72

CPC分类号： C07K14/723 ,  A61K48/00 ,  C12N2799/026

摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host. Disclosed embodiments of the invention also include antibodies that bind Human G-Protein parathyroid hormone (PTH) receptor polypeptides and methods for making and using such antibodies.

摘要翻译： 公开了人类G蛋白甲状旁腺激素（PTH）受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及在治疗上使用激动剂和拮抗剂治疗与PTH受体受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测PTH受体受体核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式水平的诊断方法。 本发明的公开的实施方案还包括结合人类G蛋白甲状旁腺激素（PTH）受体多肽的抗体以及制备和使用这些抗体的方法。

公开(公告)号：US06372891B1

公开(公告)日：2002-04-16

申请号：US09339115

申请日：1999-06-24

申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

IPC分类号： C07K1628

CPC分类号： C07K16/28 ,  A61K2039/505

摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation, in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

摘要翻译： 公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及在治疗性地使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过度表达相关的病症的方法。 还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体可溶形式的改变水平的诊断方法。

公开(公告)号：US6030804A

公开(公告)日：2000-02-29

申请号：US468011

申请日：1995-06-06

申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

IPC分类号： A61K48/00 ,  C07K14/72 ,  C12N15/12 ,  C07K14/705

CPC分类号： C07K14/723 ,  A61K48/00 ,  C12N2799/026

摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

摘要翻译： 公开了人类G蛋白甲状旁腺激素（PTH）受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及在治疗上使用激动剂和拮抗剂治疗与PTH受体受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测PTH受体受体核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式水平的诊断方法。