公开(公告)号：US20050191222A1

公开(公告)日：2005-09-01

申请号：US11119606

申请日：2005-04-29

申请人： Szu-Min Lin ,  Paul Jacobs

发明人： Szu-Min Lin ,  Paul Jacobs

IPC分类号： A61L2/14 ,  A61L2/16 ,  A61L2/20

CPC分类号： A61L2/208 ,  A61L2/14 ,  A61L2/16 ,  A61L2202/122

摘要： A method and an apparatus for sterilizing a lumen device. A lumen and a container having an interface on a wall of the container are enclosed in a chamber. The lumen is placed across the interface so that one end of the lumen is in the container and the other end is in the chamber. Germicide is introduced into the chamber, and a pressure difference is created between the two ends of the lumen, so that the germicide flows through the lumen. The lumen may alternatively be placed across an interface which separates the chamber into two areas. Germicide is introduced into the chamber, and a pressure difference is created between the two areas of the chamber, causing the germicide to flow through the lumen.

公开(公告)号：US06936223B2

公开(公告)日：2005-08-30

申请号：US10112187

申请日：2002-03-28

申请人： Thomas G. Lippold ,  Nitu Kohli ,  Pascale D. Endo ,  Henry K. Hui ,  Szu-Min Lin

发明人： Thomas G. Lippold ,  Nitu Kohli ,  Pascale D. Endo ,  Henry K. Hui ,  Szu-Min Lin

IPC分类号： A61L2/26 ,  A61L2/28 ,  C09K3/00 ,  G01N21/78 ,  G01N31/22 ,  A61L9/00

CPC分类号： A61L2/28 ,  G01N31/22 ,  G01N31/223 ,  G01N31/225 ,  G01N31/228

摘要： A chemical indicator of an aurin moiety in a substrate to detect the presence of an oxidizing agent.

摘要翻译： 底物中aurin部分的化学指示剂，以检测氧化剂的存在。

公开(公告)号：US20050042130A1

公开(公告)日：2005-02-24

申请号：US10646296

申请日：2003-08-22

申请人： Szu-Min Lin ,  Robert Lukasik

发明人： Szu-Min Lin ,  Robert Lukasik

IPC分类号： A61L2/18 ,  A61L2/20 ,  A61L2/22

CPC分类号： A61L2/208 ,  A61L2/22 ,  A61L2202/122 ,  A61L2202/24

摘要： A sterilization system employs a mist of chemical sterilant to sterilize devices such as medical instruments. A partial vacuum enhances dispersion of the mist into a sterilization chamber.

摘要翻译： 杀菌系统采用化学杀菌剂雾气对医疗仪器等设备进行灭菌。 部分真空增强了雾到灭菌室的分散。

公开(公告)号：US06685895B1

公开(公告)日：2004-02-03

申请号：US09650149

申请日：2000-08-29

申请人： Szu-Min Lin

发明人： Szu-Min Lin

IPC分类号： A61L200

CPC分类号： A61L2/22 ,  A61L2/186 ,  A61L2202/17 ,  A61L2202/24

摘要： A method and an apparatus are disclosed to reduced or eliminate the occlusion of the device in the container during the cleaning or sterilizing process, preferably with the use of a support and a controllable opening or interface. By changing the configuration of the support, the contact pattern between the device and the support can be modified to reduce occlusion during a cleaning, disinfecting or sterilization procedure.

摘要翻译： 公开了一种方法和装置，用于减少或消除在清洁或消毒过程中装置在容器中的遮挡，优选地使用支撑件和可控开口或界面。 通过改变支撑件的构型，可以改变装置和支撑件之间的接触图案，以减少在清洁，消毒或灭菌过程中的闭塞。

公开(公告)号：US06528017B2

公开(公告)日：2003-03-04

申请号：US09802226

申请日：2001-03-08

申请人： Paul Taylor Jacobs ,  Szu-Min Lin

发明人： Paul Taylor Jacobs ,  Szu-Min Lin

IPC分类号： A61L216

CPC分类号： A61L2/208 ,  A61L2/14 ,  A61L2/16 ,  A61L2202/122

摘要： A system and a method for sterilizing a lumen device involve a container in a chamber and a source of germicide. The container has an interface separating the container into two compartments and a communication port which provides fluid communication between the container and the chamber. The lumen device extends across the interface, and the two compartments are in fluid communication with each other through the lumen device. The lumen device is sterilized when the germicide flows from compartment to compartment through the lumen device.

摘要翻译： 用于对管腔装置进行灭菌的系统和方法包括在室中的容器和杀菌剂源。 容器具有将容器分成两个隔室的接口和在容器和腔室之间提供流体连通的连通口。 管腔装置延伸穿过界面，并且两个隔室通过管腔装置彼此流体连通。 当杀菌剂通过管腔装置从隔室流到隔室时，管腔装置被灭菌。

公开(公告)号：US06495100B1

公开(公告)日：2002-12-17

申请号：US09470244

申请日：1999-12-22

申请人： Szu-Min Lin ,  Anthony Lemus ,  Harold R. Williams ,  Paul Taylor Jacobs ,  Tralance O. Addy ,  Jon Morrell Jacobs

发明人： Szu-Min Lin ,  Anthony Lemus ,  Harold R. Williams ,  Paul Taylor Jacobs ,  Tralance O. Addy ,  Jon Morrell Jacobs

IPC分类号： A61L220

CPC分类号： A61L2/208 ,  A61L2/14 ,  A61L2/16 ,  A61L2202/122 ,  A61L2202/14 ,  A61L2202/24

摘要： A method for sterilizing medical devices and similar instruments in diffusion-restricted containers is provided. The sterilization method includes placing a liquid solution containing vaporizable germicide such as hydrogen peroxide into the diffusion-restricted container and vaporizing the germicide. The containers can be attachable and detachable to a sterilization system, and used as a vacuum chamber. An attachable/detachable container containing an article to be sterilized can be nested with a second container, and the article and inside and outside of the inner container are sterilized. The sterile article inside the nested containers can be transported and the sterile inner container with the sterilized article can removed from the outer container and placed in a sterile environment without contaminating the sterile environment. The sterile article can then be removed from the sterile container and utilized. Alternatively, the sterilization method may include introducing germicide vapor into an attachable/detachable container.

摘要翻译： 提供了一种在扩散限制容器中对医疗器械和类似仪器进行消毒的方法。 灭菌方法包括将含有可蒸发的杀菌剂如过氧化氢的液体溶液放置在扩散限制容器中并使杀菌剂蒸发。 容器可以安装和拆卸到灭菌系统，并用作真空室。 容纳待灭菌物品的可装卸的容器可以嵌入第二容器，并且将内部容器的内部和外部消毒。 嵌套容器内的无菌制品可以运输，具有灭菌制品的无菌内容器可以从外容器中取出并放置在无菌环境中，而不会污染无菌环境。 然后将无菌制品从无菌容器中取出并使用。 或者，灭菌方法可以包括将杀菌剂蒸气引入可附接/可拆卸的容器中。

公开(公告)号：US06451272B1

公开(公告)日：2002-09-17

申请号：US09468767

申请日：1999-12-21

申请人： Ben Fryer ,  Debra Timm ,  Szu-Min Lin

发明人： Ben Fryer ,  Debra Timm ,  Szu-Min Lin

IPC分类号： A61L220

CPC分类号： A61L2/208 ,  A61L2/28 ,  A61L2202/122 ,  A61L2202/14 ,  G01N25/28 ,  G01N25/32 ,  G01N31/223 ,  G01N31/226 ,  Y10T436/206664

摘要： A monitor of the concentration of an oxidative gas or vapor comprises a chemical coupled to a temperature probe, such as by a carrier. Addtionally, the monitor is used in a method of monitoring the concentration of an oxidative gas or vapor and in a sterilization system operated by a user. By utilizing an output signal from the temperature probe to measure the heat produced in an exothermic reaction between the monitored oxidative gas or vapor and the chemical of the monitor, the concentration of the monitored oxidative gas or vapor can be determined. The present invention represents an improvement over the monitors described in the prior art since it is more simplified, and can provide information on the local concentration of an oxidative gas or vapor at various positions within a chamber, and can be operated in size-restricted volumes. Additionally, a method of using the monitor is described, as well as a sterilization system which utilizes the monitor.

摘要翻译： 氧化气体或蒸气的浓度的监测器包括与诸如载体的温度探针连接的化学物质。 此外，监视器用于监测氧化性气体或蒸气的浓度以及在由用户操作的灭菌系统中的方法。 通过利用来自温度探测器的输出信号来测量所监测的氧化气体或蒸汽与监测器的化学物质之间的放热反应产生的热量，可以确定所监测的氧化气体或蒸气的浓度。 本发明代表了现有技术中描述的监视器的改进，因为它更简化，并且可以提供关于室内各个位置处的氧化性气体或蒸汽的局部浓度的信息，并且可以在尺寸受限的体积 。 此外，描述了使用监视器的方法，以及利用监视器的灭菌系统。

公开(公告)号：US06354312B1

公开(公告)日：2002-03-12

申请号：US09460678

申请日：1999-12-14

申请人： Szu-Min Lin ,  Paul T. Jacobs ,  Paul Leonard ,  Rodrigo Berho ,  Douglas W. Fett ,  Keith Schubert

发明人： Szu-Min Lin ,  Paul T. Jacobs ,  Paul Leonard ,  Rodrigo Berho ,  Douglas W. Fett ,  Keith Schubert

IPC分类号： B08B902

CPC分类号： A61B1/125 ,  A61B90/70 ,  A61B2090/701 ,  A61L2/18 ,  A61L2/26 ,  A61L2202/182 ,  A61L2202/24 ,  F16L37/26 ,  F16L37/38

摘要： A connector for use with a lumen device during the cleaning and sterilization of devices is provided. The connector provides fluid communication between a fluid source and the device. In particular, during the cleaning and sterilization cycle, the connection between the connector and the device does not produce occluded areas at the point of connection where the connector is sealably attached to the device.

摘要翻译： 提供了一种用于在设备的清洁和灭菌期间与管腔装置一起使用的连接器。 连接器提供流体源和设备之间的流体连通。 特别地，在清洁和灭菌循环期间，连接器和装置之间的连接在连接器可密封地连接到装置的连接点处不产生遮挡区域。

公开(公告)号：US06193931B1

公开(公告)日：2001-02-27

申请号：US09172360

申请日：1998-10-14

申请人： Szu-Min Lin ,  Paul Taylor Jacobs

发明人： Szu-Min Lin ,  Paul Taylor Jacobs

IPC分类号： A61L216

CPC分类号： A61L2/28 ,  Y10T436/196666 ,  Y10T436/20 ,  Y10T436/200833

摘要： A sterilization system using a sterilization process monitoring device which is capable of indicating the efficacy of the sterilization process in an enclosed sterilization container while still maintaining the sealed state of the sterilization container. The process monitoring device comprises at least one biological indicator and/or at least one chemical indicator. Upon completion of the sterilization cycle, the process monitoring device can be advantageously removed from the system to determine chemical and/or biological efficacy of the sterilization process. The removal of the biological and/or chemical indicators does not disturb the sterilized state of the articles inside the sterilization container.

摘要翻译： 一种消毒处理监视装置，其能够在保持灭菌容器的密封状态的同时，在灭菌容器内表示消毒处理的功效。 过程监测装置包括至少一种生物指示剂和/或至少一种化学指示剂。 灭菌循环完成后，可以有利地从系统中移除过程监控装置，以确定灭菌过程的化学和/或生物功效。 生物和/或化学指示剂的去除不会干扰消毒容器内的物品的灭菌状态。

公开(公告)号：US06187266B1

公开(公告)日：2001-02-13

申请号：US08992682

申请日：1997-12-17

申请人： Szu-Min Lin ,  Paul Taylor Jacobs

发明人： Szu-Min Lin ,  Paul Taylor Jacobs

IPC分类号： A61L900

CPC分类号： A61L2/186 ,  A61L2/22 ,  A61L2202/17 ,  A61L2202/24

摘要： A method for cleaning and sterilizing a medical device having a lumen with at least two open ends comprises the steps of: a) providing a container having at least one enclosure separated from the container by an interface, b) placing the device into the container and enclosure across the interface in such a way that one end of the lumen of the device is located in the container and the other end in the enclosure, c) generating a flow of a cleaning solution through the lumen to clean the inner surface of the lumen, d) generating a flow of rinse solution through the lumen to rinse the inner surface of the lumen, e) treating the device with a liquid sterilant, f) vaporizing the liquid sterilant in the container or enclosure thereby simultaneously sterilizing and drying the device, and providing a sterile, dry product without further rinsing. In the method, step f) can be conducted under a diffusion restricted environment, or by reducing pressure to a first predetermined pressure followed by further reducing the first pressure to a predetermined second pressure, or at controlled pump down rate. The method further comprises retaining a predetermined amount of the liquid sterilant in the container and enclosure prior to step f).

摘要翻译： 一种用于清洁和消毒具有至少两个开放端的内腔的医疗装置的方法包括以下步骤：a）提供容器，其具有通过界面与所述容器分离的至少一个外壳，b）将所述装置放置在所述容器中， 以使得该装置的内腔的一端位于容器中而另一端位于外壳内的方式，c）通过内腔产生清洁溶液的流动以清洁内腔的内表面 d）产生通过所述内腔的冲洗溶液流以冲洗所述内腔的内表面，e）用液体灭菌剂处理所述装置，f）使所述容器或外壳中的液体灭菌剂蒸发，从而同时对所述装置进行灭菌和干燥， 并提供无菌，干燥的产品，无需进一步冲洗。 在该方法中，步骤f）可以在扩散受限的环境下进行，或者通过将压力降低到第一预定压力，然后进一步将第一压力降低到预定的第二压力，或以受控的抽空率进行。 该方法还包括在步骤f）之前将预定量的液体灭菌剂保持在容器和外壳中。