公开(公告)号：US20170248563A1

公开(公告)日：2017-08-31

申请号：US15502603

申请日：2015-08-10

Applicant: MediScience Espoir Inc. ,  Sanyo Kako Co., Ltd.

Inventor： Azuma TAKASE ,  Akira SUMIYOSHI ,  Takaaki MATSUMOTO ,  Toshikatsu HAGIWARA

IPC: G01N31/16

CPC classification number: G01N31/16 ,  G01N21/77 ,  G01N21/79 ,  G01N31/00 ,  G01N31/225 ,  Y10T436/209163

Abstract: A method for measuring an amount of dissolved oxygen contained in a liquid sample, including the steps of: (1) adding a deoxygenating amino compound to a liquid sample to prepare the liquid sample having a predetermined concentration of the deoxygenating amino compound; (2) after Step (1), heating the liquid sample containing the deoxygenating amino compound at a temperature of 80° C. or more; (3) after Step (2), measuring the concentration of the deoxygenating amino compound contained in the liquid sample; and (4) calculating the amount of the dissolved oxygen contained in the liquid sample in Step (1) from the amount of the reacted deoxygenating amino compound by comparing the concentration of the deoxygenating amino compound measured in Step (3) and the concentration of the deoxygenating amino compound measured in Step (1).

公开(公告)号：US20170205357A1

公开(公告)日：2017-07-20

申请号：US15320650

申请日：2015-06-22

Applicant: President and Fellows of Harvard College

Inventor： Ian BURGESS ,  Cicely SHILLINGFORD ,  Joanna AIZENBERG

IPC: G01N21/78 ,  G01N31/22

CPC classification number: G01N21/783 ,  G01N31/223 ,  G01N31/225

Abstract: A tamper-indicating device comprising is described, including a gas-permeable casing; and a first gas-sensitive compound encapsulated within the gas-permeable casing, wherein the first gas-sensitive compound is selected to provide a visual response upon exposure to gas.

公开(公告)号：US20160146767A1

公开(公告)日：2016-05-26

申请号：US14898205

申请日：2014-06-18

Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.

Inventor： Ken SUGITO

IPC: G01N31/22

CPC classification number: G01N31/225 ,  B65D79/02

Abstract: An oxygen detecting multilayer body allows easy detection of a color change of an oxygen detecting layer, and prevention of crazing of an oxygen detecting layer. The oxygen detecting multilayer body includes a transparent resin layer, a heat seal layer, and an oxygen detecting layer containing an oxygen detecting component, placed occupying a part of a space between the transparent resin layer and the heat seal layer, wherein a spacer is placed to occupy at least a part of a space between the transparent resin layer and the heat seal layer, where the oxygen detecting layer is not provided, so as to make up a missing thickness of the oxygen detecting multilayer body, wherein the thickness of the oxygen detecting layer is from 0.5 to 40 μm, and the ratio of the thickness of the oxygen detecting layer to the thickness of the spacer is from 15:1 to 1:10.

Abstract translation: 氧检测层叠体容易地检测氧检测层的颜色变化，并防止氧检测层的龟裂。 氧检测用多层体包括透明树脂层，热封层和含有氧检测部件的氧检测层，该氧检测部件占据透明树脂层和热封层之间的空间的一部分，其中设置间隔物 占据未设置氧检测层的透明树脂层和热封层之间的空间的至少一部分，以便弥补氧检测多层体的缺失厚度，其中氧的厚度 检测层为0.5〜40μm，氧检测层的厚度与间隔物的厚度的比例为15:1〜1:10。

公开(公告)号：US20160041135A1

公开(公告)日：2016-02-11

申请号：US14777035

申请日：2014-03-17

Applicant: OHIO STATE INNOVATION FOUNDATION

Inventor： John LANNUTTI ,  Ruipeng XUE

IPC: G01N31/22 ,  G01N21/64 ,  G01N21/77

CPC classification number: G01N31/225 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/77 ,  G01N21/783 ,  G01N2021/6432 ,  G01N2021/7786

Abstract: Nanofiber-based sensors for the rapid detection, identification, and/or quantification of analytes, including gaseous analytes such as oxygen, are provided. The nanofiber-based sensors can comprise core-shell nanofibers. The core-shell nanofibers can comprise (a) a core comprising a first polymer and an sensor dispersed therein; and (b) a shell disposed coaxially around the core, comprising a second polymer.

Abstract translation: 提供了用于快速检测，鉴定和/或定量分析物的纳米纤维传感器，包括气体分析物如氧气。 基于纳米纤维的传感器可以包括核 - 壳纳米纤维。 核 - 壳纳米纤维可以包括（a）包含第一聚合物和分散在其中的传感器的芯; 和（b）围绕所述芯同轴设置的外壳，包括第二聚合物。

公开(公告)号：US20150307441A1

公开(公告)日：2015-10-29

申请号：US14420184

申请日：2013-08-07

Applicant: Biostatus Limited

Inventor： Stefan Ogrodzinski ,  Paul Smith ,  Stephanie McKeown ,  Laurence Patterson ,  Rachel Jane Errington

IPC: C07C225/36 ,  G01N31/22 ,  A61K31/277 ,  A61K31/136 ,  A61K45/06

CPC classification number: C07C225/36 ,  A61K31/136 ,  A61K31/277 ,  A61K45/06 ,  C07B59/001 ,  C07B2200/05 ,  C07C291/04 ,  C07C2603/24 ,  G01N31/225

Abstract: An anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an agent capable of reducing the level of oxygenation of a tumour, are also provided. Additionally, an option for combination with chemotherapeutic and radiotherapeutic modalities to enhance overall tumour cell kill is provided. Methods for the detection of cellular hypoxia, both in vivo and in vitro, are additionally provided.

Abstract translation: 提供了式I的蒽醌化合物（例如式II至X的化合物）及其制备方法。 还提供了用于治疗癌症的药物组合物，任选地与能够降低肿瘤氧合水平的药剂组合。 另外，提供了与化学治疗和放射治疗方式组合以增强整体肿瘤细胞杀伤的选择。 另外提供了在体内和体外检测细胞缺氧的方法。

公开(公告)号：US08987001B2

公开(公告)日：2015-03-24

申请号：US13376848

申请日：2010-06-16

Applicant: Volker Krueger ,  Rolf Beck

Inventor： Volker Krueger ,  Rolf Beck

IPC: G01N31/22 ,  G01N21/78

CPC classification number: G01N31/225 ,  G01N21/78 ,  Y10T436/207497 ,  Y10T436/209163

Abstract: The present invention relates to an oxygen indicator in which the presence or absence of oxygen is made visible by a color change, and to the use of such oxygen indicator for monitoring parenteral and enteral dosage forms.

Abstract translation: 本发明涉及氧指示剂，其中通过变色可见氧的存在或不存在，以及使用这种氧指示剂来监测肠胃外和肠内剂型。

公开(公告)号：US08748192B2

公开(公告)日：2014-06-10

申请号：US13659821

申请日：2012-10-24

Applicant: Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University

Inventor： Yanqing Tian ,  Weiwen Zhang ,  Deirdre Meldrum ,  Hongguang Lu ,  Yuguang Jin ,  Mark Holl

IPC: G01N33/00 ,  G01N33/20

CPC classification number: C12Q1/04 ,  G01N31/221 ,  G01N31/225

Abstract: The present invention relates to an optical fluorescence dual sensor comprising a probe for sensing pH, a probe for sensing oxygen, an intra-reference probe and a matrix. The present invention also relates to methods of preparing an optical fluorescence dual sensor and methods of using them.

Abstract translation: 本发明涉及一种光学荧光双传感器，其包括用于感测pH的探针，用于感测氧的探针，参考内探针和基质。 本发明还涉及制备光学荧光双重传感器的方法及其使用方法。

公开(公告)号：US08471248B2

公开(公告)日：2013-06-25

申请号：US12864877

申请日：2009-02-02

Applicant: Beat Schmidhalter ,  Thomas Schäfer ,  Peter Murer ,  Kristina Bardon ,  Stephan Allenbach ,  Andrea Ricci

Inventor： Beat Schmidhalter ,  Thomas Schäfer ,  Peter Murer ,  Kristina Bardon ,  Stephan Allenbach ,  Andrea Ricci

IPC: H01L35/24

CPC classification number: G01N31/225 ,  B01J31/1825 ,  C07F15/0033 ,  C09K2211/1011 ,  C09K2211/1059 ,  C09K2211/185 ,  H01L51/0085 ,  H01L51/5016 ,  H01L51/5048

Abstract: This invention relates to electroluminescent metal complexes of the formula (I), or (II), a process for their preparation, electronic devices comprising the metal complexes and their use in electronic devices, especially organic light emitting diodes (OLEDs), as oxygen sensitive indicators, as phosphorescent indicators in bioassays, and as catalysts.

Abstract translation: 本发明涉及式（I）或（II）的电致发光金属络合物，其制备方法，包含金属络合物的电子器件及其在电子器件中的用途，特别是有机发光二极管（OLED），作为氧敏感 指标，作为生物测定中的磷光指标，并作为催化剂。

公开(公告)号：US20130102024A1

公开(公告)日：2013-04-25

申请号：US13659821

申请日：2012-10-24

Applicant: Arizona Board of Regents, a body corporate of the

Inventor： Yanqing Tian ,  Weiwen Zhang ,  Deirdre Meldrum ,  Hongguang Lu ,  Yuguang Jin ,  Mark Holl

IPC: C12Q1/04 ,  G01N31/22

CPC classification number: C12Q1/04 ,  G01N31/221 ,  G01N31/225

Abstract: The present invention relates to an optical fluorescence dual sensor comprising a probe for sensing pH, a probe for sensing oxygen, an intra-reference probe and a matrix. The present invention also relates to methods of preparing an optical fluorescence dual sensor and methods of using them.

Abstract translation: 本发明涉及一种光学荧光双传感器，其包括用于感测pH的探针，用于感测氧的探针，参考内探针和基质。 本发明还涉及制备光学荧光双重传感器的方法及其使用方法。

公开(公告)号：US20110244592A1

公开(公告)日：2011-10-06

申请号：US13131937

申请日：2008-12-11

Applicant: Olga Vladimirovna Arzhakova

Inventor： Olga Vladimirovna Arzhakova

IPC: G01N21/00 ,  C09K11/06 ,  C09K11/02 ,  B65D77/00 ,  B05D5/06

CPC classification number: G01N31/225 ,  B01D67/0023 ,  G01N21/643 ,  G01N21/78 ,  G01N31/22 ,  G01N2021/7786

Abstract: An optochemical sensor element suitable for sensing an analyte comprises a polymeric material in which at least a portion of the polymer material is solvent crazed to provide a multiplicity of pores of controlled nanometer size, and an indicator dye impregnated into the pores, in which optochemical sensor element the indicator dye is a long-decay photoluminescent dye selected from the group consisting of: phosphorescent platinum(II)—and palladium (II) complexes of porphyrin dyes such as octaethylporphine, coproporphyrin, octaethylporphine -ketone, benzoporphine, tetra (pentafluorophenyl) porphine, chlorin e6; fluorescent complexes of ruthenium (II), osmium(II), iridium(III) and europium (III); or derivatives or close analogs of these dyes. The sensor element in the presence of the analyte alters a photoluminescence parameter thus allowing sensing and/or quantification of the analyte.

Abstract translation: 适于感测分析物的光化学传感器元件包括聚合物材料，其中至少一部分聚合物材料被溶剂硬化以提供多个受控纳米尺寸的孔，以及浸渍到孔中的指示剂染料，其中光化学传感器 元素指示剂染料是选自以下的长衰变光致发光染料：磷光铂（II） - 和卟啉染料如八乙基卟吩，cop卟啉，八乙基卟吩酮，苯并菲，四（五氟苯基）卟吩的钯（II）络合物 ，二氢卟酚e6; 钌（II），锇（II），铱（III）和铕（III）的荧光复合物; 或这些染料的衍生物或紧密类似物。 在存在分析物的情况下，传感器元件会改变光致发光参数，从而允许检测和/或定量分析物。