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公开(公告)号:US08883788B2
公开(公告)日:2014-11-11
申请号:US13814035
申请日:2011-08-03
申请人: Tomoaki Hasui , Makoto Fushimi , Hironori Kokubo , Takenori Hitaka , Shotaro Miura , Takahiko Taniguchi
发明人: Tomoaki Hasui , Makoto Fushimi , Hironori Kokubo , Takenori Hitaka , Shotaro Miura , Takahiko Taniguchi
IPC分类号: A61K31/50 , A61K31/501 , C07D403/14 , C07D401/12 , C07D471/04 , A61K9/20 , C07D487/04 , C07D401/14 , A61K31/00
CPC分类号: C07D403/14 , A61K9/2018 , A61K9/2059 , A61K31/00 , C07D401/12 , C07D401/14 , C07D471/04 , C07D487/04
摘要: Provided is a compound having a PDE10A inhibitory action, and useful as a medicament for the prophylaxis or treatment of mental diseases such as schizophrenia and the like, and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.
摘要翻译: 提供具有PDE10A抑制作用的化合物,可用作预防或治疗精神疾病如精神分裂症等的药物等。 由式(I)表示的化合物或其盐,其中每个符号如说明书中所定义。
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公开(公告)号:US20130137700A1
公开(公告)日:2013-05-30
申请号:US13814035
申请日:2011-08-03
申请人: Tomoaki Hasui , Makoto Fushimi , Hironori Kokubo , Takenori Hitaka , Shotaro Miura , Jun Kunitomo , Takahiko Taniguchi
发明人: Tomoaki Hasui , Makoto Fushimi , Hironori Kokubo , Takenori Hitaka , Shotaro Miura , Jun Kunitomo , Takahiko Taniguchi
IPC分类号: C07D403/14 , C07D471/04 , C07D401/12 , C07D487/04 , C07D401/14
CPC分类号: C07D403/14 , A61K9/2018 , A61K9/2059 , A61K31/00 , C07D401/12 , C07D401/14 , C07D471/04 , C07D487/04
摘要: Provided is a compound having a PDE10A inhibitory action, and useful as a medicament for the prophylaxis or treatment of mental diseases such as schizophrenia and the like, and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.
摘要翻译: 提供具有PDE10A抑制作用的化合物,可用作预防或治疗精神疾病如精神分裂症等的药物等。 由式(I)表示的化合物或其盐,其中每个符号如说明书中所定义。
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公开(公告)号:US07581769B2
公开(公告)日:2009-09-01
申请号:US11811008
申请日:2007-06-07
IPC分类号: B60R19/12
CPC分类号: B60R19/18 , B60R2019/184 , B60R2019/188
摘要: The present invention discloses a bumper absorber that is provided on an automobile between a bumper reinforcement and a bumper fascia, comprising a first energy absorbing portion formed by foaming a resin molded material; the first energy absorbing portion extending from the bumper reinforcement toward the bumper fascia; a second energy absorbing portion formed by a resin molded material; the second energy absorbing portion extending from the bumper reinforcement toward the bumper fascia at a position where a space that permits buckling is formed between the first energy absorbing portion and the second energy absorbing portion on the bumper reinforcement side; a crosslinking portion disposed facing a vehicle interior side of the bumper fascia; and the crosslinking portion fastening the first energy absorbing portion and the second energy absorbing portion together while sealing an opening between the first energy absorbing portion and the second energy absorbing portion on the bumper fascia side.
摘要翻译: 本发明公开了一种保险杠吸收器,其设置在保险杠加强件和保险杠面板之间的汽车上,包括通过使树脂模制材料发泡而形成的第一能量吸收部分; 所述第一能量吸收部分从所述保险杠加强件延伸到保险杠面板; 由树脂模制材料形成的第二能量吸收部分; 所述第二能量吸收部从所述保险杠加强件朝向保险杠面板延伸,在所述保险杠加强侧的所述第一能量吸收部和所述第二能量吸收部之间形成有允许弯曲的空间的位置; 布置成面向保险杠面板的车辆内侧的交联部分; 并且所述交联部分将所述第一能量吸收部分和所述第二能量吸收部分紧固在一起,同时密封所述保险杠面板侧上的所述第一能量吸收部分和所述第二能量吸收部分之间的开口。
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公开(公告)号:US20090105253A1
公开(公告)日:2009-04-23
申请号:US11887936
申请日:2006-04-06
申请人: Keiji Kubo , Mamoru Tobisu , Eiji Honda , Takahiko Taniguchi , Yoshiyuki Fukase , Masaki Kawamura , Masaharu Nakayama
发明人: Keiji Kubo , Mamoru Tobisu , Eiji Honda , Takahiko Taniguchi , Yoshiyuki Fukase , Masaki Kawamura , Masaharu Nakayama
IPC分类号: A61K31/5377 , C07D249/06 , C07D413/12 , A61K31/4192
CPC分类号: C07D249/06 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D411/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention relates to a thrombin receptor antagonist containing a compound represented by the formula (I) wherein R1a, R1b and R2 are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or an optionally substituted alkoxy, R3 is a group represented by the formula —NHCOR4, —NHSO2R5, —NHCON(R6a)(R6b), —NHCOOR7 or —CONHR8 wherein R4, R5, R6a, R6b, R7 and R8 are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like), ring A is monocyclic aromatic ring optionally further having substituent(s), R1a and R1b are optionally bonded to each other to form an optionally substituted nitrogen-containing non-aromatic heterocycle, or a salt thereof or a prodrug thereof. The thrombin receptor antagonist of the present invention has a thrombin receptor (particularly PAR-1) antagonistic action and is useful for the prophylaxis or treatment of PAR-1 mediated pathological condition or disease.
摘要翻译: 本发明涉及含有式(I)表示的化合物的凝血酶受体拮抗剂,其中R1a,R1b和R2各自为氢原子,任选取代的烃基,任选取代的杂环基或任选取代的烷氧基,R 3 是由式-NHCOR4,-NHSO2R5,-NHCON(R6a)(R6b),-NHCOOR7或-CONHR8表示的基团,其中R4,R5,R6a,R6b,R7和R8各自为氢原子,任选取代的烃基 ,任选取代的杂环基等),环A是任选进一步具有取代基的单环芳环,R 1a和R 1b任选地彼此键合以形成任选取代的含氮非芳族杂环,或盐 或其前药。 本发明的凝血酶受体拮抗剂具有凝血酶受体(特别是PAR-1)拮抗作用,可用于预防或治疗PAR-1介导的病理状态或疾病。
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公开(公告)号:US20070244132A1
公开(公告)日:2007-10-18
申请号:US10592812
申请日:2005-06-01
IPC分类号: A61K31/519 , A61K31/517 , A61P35/00 , A61P43/00 , C07D239/70
CPC分类号: C07D487/04 , C07D487/16
摘要: The present invention relates to a compound represented by the formula: wherein W is C(R1) or N, each A is an optionally substituted aryl group or a heteroaryl group, X1 is —NR3—Y1—, —O—, —S—, —SO—, —SO2— or —CHR3— wherein R3 is a hydrogen atom or an optionally substituted aliphatic hydrocarbon group, or R3 is optionally bonded to A to form an optionally substituted ring structure, R1 is a hydrogen atom or an optionally substituted group bonded via a carbon atom, a nitrogen atom or an oxygen atom, R2 is a hydrogen atom or optionally substituted group bonded via a carbon atom or a sulfur atom, or R1 and R2, or R2 and R3 are optionally bonded to form an optionally substituted ring structure, or a salt thereof, and a tyrosine kinase inhibitor or an agent for the prophylaxis or treatment of cancer, which contains this compound or a prodrug thereof.
摘要翻译: 本发明涉及由下式表示的化合物:其中W是C(R 1)或N,每个A是任选取代的芳基或杂芳基,X 1, -O - , - S - , - SO - , - SO 2 - 或 - CHR 3 - 其中R 3是氢原子或任选取代的脂族烃基,或R 3任选地与A键合,形成 任选取代的环结构,R 1是氢原子或经由碳原子,氮原子或氧原子键合的任选取代的基团,R 2是氢原子 或通过碳原子或硫原子键合的任选取代的基团,或R 1和R 2,R 2,R 2和R 2, 3任选地键合以形成任选取代的环结构,或其盐,和酪氨酸激酶抑制剂或用于预防或治疗癌症的试剂,其含有该化合物或产物 g。
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公开(公告)号:US20070080562A1
公开(公告)日:2007-04-12
申请号:US10579398
申请日:2004-11-15
IPC分类号: B62D25/20
CPC分类号: B60R21/04 , B60R2021/0046 , B60R2021/0414
摘要: An impact absorbing body disposed below feet of an occupant of an automobile and interposed between a body panel and a floor covering laid apart from the body panel toward a cabin, configured such that a plurality of load supporting portions, having V-lettered cross-sections forming grooves arranged parallel to a face facing toward the cabin of said body panel, are disposed side by side along the face facing toward the cabin of said body panel and neighboring load supporting portions are connected by a flat-plate-shaped bridge portion.
摘要翻译: 1.一种冲击吸收体,其设置在汽车乘员的脚下方,并且插入在车身面板和从车身面板朝向车厢布置的地板覆盖物之间,被配置为具有V字形横截面的多个负载支撑部 与面向所述车身板的车厢的面平行布置的形成槽沿着面向所述车身板的车厢的面并排配置,并且相邻的负载支撑部通过平板状的桥接部连接。
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公开(公告)号:US5900369A
公开(公告)日:1999-05-04
申请号:US111857
申请日:1998-07-08
CPC分类号: C12P41/004 , C12P15/00
摘要: Optically active oxodicyclopentadiene is produced by adding lipase into ketoalcohol (1) and vinyl acetate, stirring them to obtain optically active acetate, and methylating and oxidizing to cleavage the reactant, and treating the product under basic conditions. ##STR1##
摘要翻译: 通过将脂肪酶加入到酮醇(1)和乙酸乙烯酯中,搅拌以获得光学活性乙酸酯,并进行甲基化和氧化以切割反应物,并在碱性条件下处理产物,产生光学活性氧化二环戊二烯。
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