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34 条记录 (耗时 0.041 秒)

    PD-1, A Receptor for B7-4, and Uses Therefor
    34.
    发明申请
    PD-1, A Receptor for B7-4, and Uses Therefor 审中-公开

    公开(公告)号：US20110033884A1

    公开(公告)日：2011-02-10

    申请号：US12761704

    申请日：2010-04-16

    申请人： Clive Wood ,  Gordon J. Freeman ,  Divya Chaudhary

    发明人： Clive Wood ,  Gordon J. Freeman ,  Divya Chaudhary

    IPC分类号： C12Q1/02

    CPC分类号： G01N33/505 ,  G01N33/5052 ,  G01N33/6863 ,  G01N2333/70532 ,  G01N2333/912

    摘要： Disclosed is a method for modulating an immune response by modulating signaling via PD-1. The immune response may be downregulated by increasing signaling via PD-1, or may be upregulated by decreasing signaling via PD-1. Agents which are useful for stimulating signaling via PD-1 to downregulate an immune response include an activating antibody that recognizes PD-1, a form of B7-4 that binds to an inhibitory receptor, and a small molecule that binds to PD-1. Agents which are useful for inhibiting signaling via PD-1 to upregulate an immune response include a blocking antibody that recognizes PD-1, a non-activating form of B7-4, an antibody that recognizes B7-4, and a soluble form of PD-1. Also disclosed is a method for modulating the interaction of B7-4 with an inhibitory receptor on an immune cell. The method comprises contacting an antigen presenting cell which expresses B7-4 with an agent such as a form of B7-4, a form of PD-1, or an agent that modulates the interaction of B7-4 and PD-1. Also disclosed is a method for inhibiting activation of an immune cell via a non-apoptotic mechanism by increasing the activity or expression of PD-1 in the immune cell. The disclosed methods for modulating an immune response are useful, for instance as therapeutic treatment of a subject with conditions that would benefit from immune response modulation. For instance, a condition such as a tumor, a neurological disease, or an immunosuppressive disease, would be treated by upregulating an immune response, and conditions such as a transplant, an allergy, or an autoimmune disorder would benefit from downregulation of an immune response. Assays for identifying compounds which modulate the activity of, or signaling via, B7-4, or PD-1, especially which modulate the binding of B7-4 or PD-1 to a target molecule are also disclosed. Further disclosed are a vaccine and also other compositions which contain agents that modulate signaling via PD-1.