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公开(公告)号：US07977359B2
公开(公告)日：2011-07-12
申请号：US11553946
申请日：2006-10-27
申请人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Brian Andrew Stearns , Jeffrey Roger Roppe , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Mustapha Haddach
发明人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Brian Andrew Stearns , Jeffrey Roger Roppe , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Mustapha Haddach
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： C07D401/14 , C07D401/12 , C07D403/10 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
摘要翻译： 本文描述了含有调节5-脂氧合酶活化蛋白（FLAP）的活性的化合物的化合物和药物组合物。 本文还描述了使用这样的FLAP调节剂单独和与其它化合物组合用于治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症或疾病的方法。
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公开(公告)号：US20090192171A1
公开(公告)日：2009-07-30
申请号：US12089707
申请日：2006-10-30
申请人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Brian Andrew Stearns , Jeffrey Roger Roppe , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Mustapha Haddach
发明人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Brian Andrew Stearns , Jeffrey Roger Roppe , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Mustapha Haddach
IPC分类号： A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/444 , C07D401/14 , C07D417/14 , C07D413/14 , A61K31/501 , A61P11/00 , A61P29/00 , A61P9/00
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
摘要翻译： 本文描述了含有调节5-脂氧合酶活化蛋白（FLAP）的活性的化合物的化合物和药物组合物。 本文还描述了使用这样的FLAP调节剂单独和与其它化合物组合用于治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症或疾病的方法。
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公开(公告)号：US20100280049A1
公开(公告)日：2010-11-04
申请号：US12741808
申请日：2008-10-31
IPC分类号： A61K31/4965 , C07D471/10 , C07D487/04 , A61K31/438 , A61K31/519 , C07D471/04 , A61P11/06 , A61P11/02 , A61P11/08 , A61P37/08 , A61P19/02 , A61P17/06 , A61P17/00 , A61P11/00 , A61P1/00 , A61P35/00 , A61P9/10 , A61P7/00 , A61P25/00
CPC分类号： C07D471/10 , C07D209/54
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds that antagonize the PGD2 activated chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2). Also described herein are methods of using such CRTH2 antagonists, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2 mediated conditions or diseases.
摘要翻译： 本文描述了含有拮抗在TH2细胞（CRTH2）上表达的PGD2激活的化学引诱物受体同源分子的化合物的化合物和药物组合物。 本文还描述了使用这种CRTH2拮抗剂单独和与其它化合物组合用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US08168678B2
公开(公告)日：2012-05-01
申请号：US12362439
申请日：2009-01-29
IPC分类号： A01N37/12
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
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35.发明授权N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors 有权前列腺素D2受体的N，N-二取代的氨基烷基联苯拮抗剂公开(公告)号：US08338484B2
公开(公告)日：2012-12-25
申请号：US13297160
申请日：2011-11-15
IPC分类号： A01N37/12
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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![CYCLOALKANE[B]INDOLE ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS](/abs-image/US/2011/06/23/US20110152338A1/abs.jpg.150x150.jpg)
36.发明申请CYCLOALKANE[B]INDOLE ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 失效CYCLOALKANE [B]包含PROSTAGLANDIN D2受体的拮抗剂公开(公告)号：US20110152338A1
公开(公告)日：2011-06-23
申请号：US12999133
申请日：2009-06-23
IPC分类号： A61K31/403 , C07D209/80 , A61P11/06 , A61P11/00 , A61P37/08 , A61P19/02 , A61P17/06 , A61P1/00
CPC分类号： C07D209/88 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0043 , A61K9/0048 , A61K9/0056 , A61K9/006 , A61K9/0078 , A61K9/06 , A61K9/4866
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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![Cycloalkane[B]indole antagonists of prostaglandin D2 receptors](/abs-image/US/2013/08/06/US08501959B2/abs.jpg.150x150.jpg)
公开(公告)号：US08501959B2
公开(公告)日：2013-08-06
申请号：US12999133
申请日：2009-06-23
IPC分类号： C07D209/94 , A61K31/40
CPC分类号： C07D209/88 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0043 , A61K9/0048 , A61K9/0056 , A61K9/006 , A61K9/0078 , A61K9/06 , A61K9/4866
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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![Cycloalkane[B]azaindole antagonists of prostaglandin D2 receptors](/abs-image/US/2011/10/11/US08034826B2/abs.jpg.150x150.jpg)
38.发明授权公开(公告)号：US08034826B2
公开(公告)日：2011-10-11
申请号：US12613424
申请日：2009-11-05
IPC分类号： A61K31/437 , C07D471/04 , A61P11/00 , A61P37/08 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4427
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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![CYCLOALKANE[B]AZAINDOLE ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS](/abs-image/US/2010/05/06/US20100113503A1/abs.jpg.150x150.jpg)
39.发明申请公开(公告)号：US20100113503A1
公开(公告)日：2010-05-06
申请号：US12613424
申请日：2009-11-05
IPC分类号： A61K31/437 , C07D471/04 , A61P11/00 , A61P37/08 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4427
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US08383654B2
公开(公告)日：2013-02-26
申请号：US13129078
申请日：2009-11-16
申请人： John Howard Hutchinson , Nicholas Simon Stock , Jeffrey Roger Roppe , Brian Andrew Stearns , Timothy Parr
发明人： John Howard Hutchinson , Nicholas Simon Stock , Jeffrey Roger Roppe , Brian Andrew Stearns , Timothy Parr
IPC分类号： A61K31/4245 , A61K31/4155 , A61K31/415 , C07D231/12 , C07D271/06 , C07D403/06
CPC分类号： C07D403/06 , A61K31/4174 , A61K31/4178 , C07D231/12 , C07D271/06
摘要： Described herein are heteroaryl compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的杂芳基化合物。 还描述了包括所述杂芳基化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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