公开(公告)号：US09688624B2

公开(公告)日：2017-06-27

申请号：US13519292

申请日：2011-01-05

申请人： Jason Edward Brittain ,  Christopher David King ,  Brian Andrew Stearns

发明人： Jason Edward Brittain ,  Christopher David King ,  Brian Andrew Stearns

IPC分类号： C07C323/41

CPC分类号： C07C323/41 ,  C07B2200/13

摘要： Described herein is the DP2 antagonist 2-(3-(2-((tert-butylthio)methyl)-4-(2,2-dimethyl-propionylamino)phenoxy)-4-methoxyphenyl)acetic acid, or a pharmaceutically acceptable salt thereof. Also described are methods of preparing the DP2 antagonist, or a pharmaceutically acceptable salt thereof. Also described herein are pharmaceutical compositions suitable for administration to a mammal that include the DP2 antagonist, or a pharmaceutically acceptable salt thereof, and methods of using such pharmaceutical compositions for treating respiratory diseases or conditions, allergic diseases or conditions, inflammatory diseases or conditions, as well as other prostaglandin D2-dependent or prostaglandin D2-mediated diseases or conditions.

公开(公告)号：US08778983B2

公开(公告)日：2014-07-15

申请号：US12893902

申请日：2010-09-29

申请人： Ryan Clark ,  Brian Andrew Stearns ,  Lucy Zhao ,  Thomas Jon Seiders ,  Deborah Volkots ,  Jeannie M. Arruda ,  David Nathan Zalatan

发明人： Ryan Clark ,  Brian Andrew Stearns ,  Lucy Zhao ,  Thomas Jon Seiders ,  Deborah Volkots ,  Jeannie M. Arruda ,  David Nathan Zalatan

IPC分类号： A61K31/4192 ,  C07D413/06 ,  C07D413/12

CPC分类号： C07D231/38 ,  C07D261/08 ,  C07D261/14 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

公开(公告)号：US20130072490A1

公开(公告)日：2013-03-21

申请号：US13499052

申请日：2010-09-29

申请人： Ryan Clark ,  Brian Andrew Stearns ,  Jill Melissa Scott ,  Heather Renee Coate ,  Lucy Zhao ,  Thomas Jon Seiders ,  Deborah Volkots ,  Jeannie Arruda ,  Nicholas Simon Stock ,  Yen Pham Truong ,  David Nathan Zalatan

发明人： Ryan Clark ,  Brian Andrew Stearns ,  Jill Melissa Scott ,  Heather Renee Coate ,  Lucy Zhao ,  Thomas Jon Seiders ,  Deborah Volkots ,  Jeannie Arruda ,  Nicholas Simon Stock ,  Yen Pham Truong ,  David Nathan Zalatan

IPC分类号： A61K31/42 ,  C07D413/14 ,  C07D413/04 ,  C07D261/14 ,  C07D413/06 ,  C07D261/06

CPC分类号： C07D231/38 ,  C07D261/08 ,  C07D261/14 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。

公开(公告)号：US20120289522A1

公开(公告)日：2012-11-15

申请号：US13498491

申请日：2010-10-01

申请人： Thomas J. Seiders ,  Lucy Zhao ,  Jeannie Arruda ,  Bowei Wang ,  Brian Andrew Stearns ,  Yen Pham Truong ,  Jill Melissa Scott ,  John Howard Hutchinson ,  Ryan Clark ,  Heather Renee Coate ,  Nicholas Simon Stock ,  Deborah Volkots

发明人： Thomas J. Seiders ,  Lucy Zhao ,  Jeannie Arruda ,  Bowei Wang ,  Brian Andrew Stearns ,  Yen Pham Truong ,  Jill Melissa Scott ,  John Howard Hutchinson ,  Ryan Clark ,  Heather Renee Coate ,  Nicholas Simon Stock ,  Deborah Volkots

IPC分类号： A61K31/42 ,  C07D261/08 ,  C07D413/12 ,  A61K31/4439 ,  C07D417/12 ,  A61P17/00 ,  C07D495/04 ,  A61K31/519 ,  A61P11/00 ,  A61P13/12 ,  A61P1/16 ,  C07D261/14 ,  A61K31/428

CPC分类号： C07D261/08 ,  A61K31/42 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/519 ,  C07D261/14 ,  C07D261/18 ,  C07D405/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  C07D495/04

摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

公开(公告)号：US08168678B2

公开(公告)日：2012-05-01

申请号：US12362439

申请日：2009-01-29

申请人： John Howard Hutchinson ,  Brian Andrew Stearns ,  Yen Pham Truong

发明人： John Howard Hutchinson ,  Brian Andrew Stearns ,  Yen Pham Truong

IPC分类号： A01N37/12

CPC分类号： A61K31/5375 ,  A61K31/17 ,  A61K31/192 ,  A61K31/27 ,  A61K31/277 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/4412 ,  A61K31/47 ,  A61K31/513 ,  A61K45/06 ,  C07C233/47 ,  C07C233/54 ,  C07C233/63 ,  C07C271/22 ,  C07C271/24 ,  C07C271/28 ,  C07C271/34 ,  C07C275/24 ,  C07C275/26 ,  C07C311/08 ,  C07C317/50 ,  C07C323/63 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  Y10S514/826

摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

公开(公告)号：US08071807B2

公开(公告)日：2011-12-06

申请号：US12497343

申请日：2009-07-02

申请人： John Howard Hutchinson ,  Thomas Jon Seiders ,  Bowei Wang ,  Jeannie M. Arruda ,  Brian Andrew Stearns

发明人： John Howard Hutchinson ,  Thomas Jon Seiders ,  Bowei Wang ,  Jeannie M. Arruda ,  Brian Andrew Stearns

IPC分类号： C07C323/57 ,  C07C321/20 ,  C07C229/18 ,  C07C229/42 ,  C07C255/54 ,  A61K31/167 ,  A61K31/10

CPC分类号： C07C323/42 ,  A61K31/235 ,  C07C317/28 ,  C07C323/41 ,  C07C323/44 ,  C07C323/49 ,  C07C2601/02

摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。

公开(公告)号：US08034826B2

公开(公告)日：2011-10-11

申请号：US12613424

申请日：2009-11-05

申请人： John Howard Hutchinson ,  Brian Andrew Stearns ,  Jill Melissa Scott

发明人： John Howard Hutchinson ,  Brian Andrew Stearns ,  Jill Melissa Scott

IPC分类号： A61K31/437 ,  C07D471/04 ,  A61P11/00 ,  A61P37/08 ,  A61P29/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/4427

摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。

公开(公告)号：US20110190227A1

公开(公告)日：2011-08-04

申请号：US12999621

申请日：2009-07-02

申请人： John Howard Hutchinson ,  Thomas Jon Seiders ,  Bowei Wang ,  Jeannie M. Arruda ,  Brian Andrew Stearns ,  Jeffrey Roger Roppe

发明人： John Howard Hutchinson ,  Thomas Jon Seiders ,  Bowei Wang ,  Jeannie M. Arruda ,  Brian Andrew Stearns ,  Jeffrey Roger Roppe

IPC分类号： A61K31/7028 ,  C07C59/68 ,  C07C317/46 ,  C07D277/36 ,  C07D215/36 ,  C07D213/70 ,  C07D213/71 ,  C07D285/125 ,  C07H15/203 ,  A61K31/192 ,  A61K31/426 ,  A61K31/47 ,  A61K31/435 ,  A61K31/433 ,  A61P11/00 ,  A61P29/00 ,  A61P37/08 ,  A61P11/06 ,  A61P9/12 ,  A61P19/02 ,  A61P17/06 ,  A61P35/00 ,  A61P43/00 ,  A61P9/00 ,  A61P9/10 ,  A61P11/02

CPC分类号： C07C323/42 ,  A61K31/235 ,  C07C317/28 ,  C07C323/41 ,  C07C323/44 ,  C07C323/49 ,  C07C2601/02

摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists Of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了药物组合物和药物，其包括本文所述的化合物是PGD 2受体的拮抗剂。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。

公开(公告)号：US20110118315A1

公开(公告)日：2011-05-19

申请号：US13012045

申请日：2011-01-24

申请人： John H. Hutchinson ,  Petpiboon Peppi Prasit ,  Mark Moran ,  Jillian F. Evans ,  Yiwei Li ,  Jasmine Eleanor Zunic ,  Jeannie M. Arruda ,  Nicholas Simon Stock ,  Brian Andrew Stearns ,  Mustapha Haddach ,  Jeffrey Roger Roppe

发明人： John H. Hutchinson ,  Petpiboon Peppi Prasit ,  Mark Moran ,  Jillian F. Evans ,  Yiwei Li ,  Jasmine Eleanor Zunic ,  Jeannie M. Arruda ,  Nicholas Simon Stock ,  Brian Andrew Stearns ,  Mustapha Haddach ,  Jeffrey Roger Roppe

IPC分类号： A61K31/444 ,  A61P11/00 ,  A61P29/00 ,  A61P11/06 ,  A61P9/00

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D403/10 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

摘要翻译： 本文描述了含有调节5-脂氧合酶活化蛋白（FLAP）的活性的化合物的化合物和药物组合物。 本文还描述了使用这样的FLAP调节剂单独和与其它化合物组合用于治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症或疾病的方法。

公开(公告)号：US20110098302A1

公开(公告)日：2011-04-28

申请号：US12867476

申请日：2009-02-12

申请人： John Howard Hutchinson ,  Thomas Jon Seiders ,  Brian Andrew Stearns ,  Bowei Wang ,  Yen Pham Truong ,  Jeannie M. Arruda

发明人： John Howard Hutchinson ,  Thomas Jon Seiders ,  Brian Andrew Stearns ,  Bowei Wang ,  Yen Pham Truong ,  Jeannie M. Arruda

IPC分类号： A61K31/5377 ,  C07D233/02 ,  A61K31/4166 ,  C07D207/46 ,  A61K31/40 ,  C07D263/58 ,  A61K31/423 ,  C07D413/10 ,  C07D417/10 ,  A61K31/427 ,  A61K31/4439 ,  A61P11/06 ,  A61P37/08 ,  A61P11/00 ,  A61P19/02 ,  A61P35/00 ,  A61P17/06 ,  A61P1/00 ,  A61P17/02

CPC分类号： C07D233/32 ,  C07D207/38 ,  C07D263/22 ,  C07D263/52 ,  C07D413/12 ,  C07D417/12

摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述的PGD 2受体的拮抗剂的药物组合物和药物，以及将PGD2受体单独和与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2的方法 介导的病症或疾病。