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1.发明申请公开(公告)号：US20110118315A1
公开(公告)日：2011-05-19
申请号：US13012045
申请日：2011-01-24
申请人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Brian Andrew Stearns , Mustapha Haddach , Jeffrey Roger Roppe
发明人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Brian Andrew Stearns , Mustapha Haddach , Jeffrey Roger Roppe
IPC分类号： A61K31/444 , A61P11/00 , A61P29/00 , A61P11/06 , A61P9/00
CPC分类号： C07D401/14 , C07D401/12 , C07D403/10 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
摘要翻译： 本文描述了含有调节5-脂氧合酶活化蛋白（FLAP）的活性的化合物的化合物和药物组合物。 本文还描述了使用这样的FLAP调节剂单独和与其它化合物组合用于治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症或疾病的方法。
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公开(公告)号：US08399666B2
公开(公告)日：2013-03-19
申请号：US12089707
申请日：2006-10-30
申请人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Brian Andrew Stearns , Jeffrey Roger Roppe , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Mustapha Haddach
发明人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Brian Andrew Stearns , Jeffrey Roger Roppe , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Mustapha Haddach
IPC分类号： A61P9/00 , A61P11/00 , A61P29/00 , C07D401/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
摘要翻译： 本文描述了含有调节5-脂氧合酶活化蛋白（FLAP）的活性的化合物的化合物和药物组合物。 本文还描述了使用这样的FLAP调节剂单独和与其它化合物组合用于治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症或疾病的方法。
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公开(公告)号：US07977359B2
公开(公告)日：2011-07-12
申请号：US11553946
申请日：2006-10-27
申请人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Brian Andrew Stearns , Jeffrey Roger Roppe , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Mustapha Haddach
发明人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Brian Andrew Stearns , Jeffrey Roger Roppe , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Mustapha Haddach
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： C07D401/14 , C07D401/12 , C07D403/10 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
摘要翻译： 本文描述了含有调节5-脂氧合酶活化蛋白（FLAP）的活性的化合物的化合物和药物组合物。 本文还描述了使用这样的FLAP调节剂单独和与其它化合物组合用于治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症或疾病的方法。
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公开(公告)号：US20090192171A1
公开(公告)日：2009-07-30
申请号：US12089707
申请日：2006-10-30
申请人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Brian Andrew Stearns , Jeffrey Roger Roppe , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Mustapha Haddach
发明人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Brian Andrew Stearns , Jeffrey Roger Roppe , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Mustapha Haddach
IPC分类号： A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/444 , C07D401/14 , C07D417/14 , C07D413/14 , A61K31/501 , A61P11/00 , A61P29/00 , A61P9/00
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
摘要翻译： 本文描述了含有调节5-脂氧合酶活化蛋白（FLAP）的活性的化合物的化合物和药物组合物。 本文还描述了使用这样的FLAP调节剂单独和与其它化合物组合用于治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症或疾病的方法。
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公开(公告)号：US20090221574A1
公开(公告)日：2009-09-03
申请号：US12089706
申请日：2006-11-03
申请人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Yiwei Li , Jasmine Eleanor Zunic , Mustapha Haddach , Nicholas Simon Stock
发明人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Yiwei Li , Jasmine Eleanor Zunic , Mustapha Haddach , Nicholas Simon Stock
IPC分类号： A61K31/5377 , C07D401/12 , A61K31/454 , C07D415/00 , A61K31/427 , C07D403/02 , A61K31/506 , C07D413/14
CPC分类号： C07D401/10 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
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公开(公告)号：US07405302B2
公开(公告)日：2008-07-29
申请号：US11538762
申请日：2006-10-04
申请人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Jasmine Eleanor Zunic , Nicholas Simon Stock
发明人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Jasmine Eleanor Zunic , Nicholas Simon Stock
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D491/02 , C07D471/04 , C07D498/02
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
摘要翻译： 本文描述了含有调节5-脂氧合酶活化蛋白（FLAP）的活性的化合物的化合物和药物组合物。 本文还描述了使用这样的FLAP调节剂单独和与其它化合物组合用于治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症或疾病的方法。
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7.发明申请公开(公告)号：US20120027842A1
公开(公告)日：2012-02-02
申请号：US13141673
申请日：2009-12-21
IPC分类号： A61K9/127 , A61K31/5377 , A61K38/13 , A61K31/56 , C07D403/14 , C07D401/14 , C07D413/14 , A61P31/12 , A61P31/10 , A61P31/00 , A61P29/00 , A61P35/00 , A61P27/02 , A61P27/06 , A61P27/04 , A61K31/513
CPC分类号： A61K31/497 , A61K9/0048 , A61K31/506 , A61K31/51
摘要： Described herein are topical formulations for administration to an eye, wherein the formulation is administered to treat ophthalmic diseases, disorders, or conditions. A topical formulation for administration to an eye disclosed herein comprises a therapeutically-effective amount of a FLAP inhibitor compound formulated for topical administration to the eye.
摘要翻译： 本文描述的是用于给予眼睛的局部制剂，其中施用该制剂以治疗眼科疾病，病症或病症。 用于给予本文公开的眼睛的局部制剂包含治疗有效量的配制用于眼部局部给药的FLAP抑制剂化合物。
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8.发明授权Peptide sequences and antipeptide antisera for detecting human cyclooxygenase-1 and cyclooxygenase-2 proteins 失效用于检测人类环氧合酶-1和环加氧酶-2蛋白的肽序列和抗肽抗血清
公开(公告)号：US5459239A
公开(公告)日：1995-10-17
申请号：US186364
申请日：1994-01-24
CPC分类号： C12N9/0069 , C07K2319/00 , C12N2799/023 , Y10S530/812
摘要： This invention discloses novel immunogenic peptide sequences, derived from the human cyclooxygenase-1 and cyclooxygenase-2 cDNAs which elicit specific non cross-reactive antibody responses. Assays are also disclosed for selectively and independently detecting cyclooxygenase-1 or cyclooxygenase-2 proteins present in a given biological sample.
摘要翻译： 本发明公开了衍生自引发特异性非交叉反应性抗体应答的人环加氧酶-1和环加氧酶-2 cDNA的新型免疫原性肽序列。 还公开了用于选择性和独立地检测给定生物样品中存在的环加氧酶-1或环加氧酶-2蛋白的测定。
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9.发明申请TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS 审中-公开用于治疗皮肤病症的瓣膜抑制剂的局限性制剂公开(公告)号：US20110311613A1
公开(公告)日：2011-12-22
申请号：US13141665
申请日：2009-12-21
IPC分类号： A61K9/127 , A61K31/444 , A61K31/4709 , A61K31/405 , A61K31/47 , A61K31/56 , A61K38/13 , A61P17/00 , A61P35/00 , A61P37/00 , A61P37/08 , A61P17/06 , A61P17/04 , A61P17/02 , A61P17/10 , A61K31/506 , B82Y5/00
CPC分类号： A61K31/00 , A61K9/0014 , A61K31/497 , A61K31/506 , A61K31/51 , A61L15/44 , A61L26/0066 , A61L2300/432
摘要： Described herein, are topical formulations for treating a dermatological disease, disorder, or condition. Topical formulations disclosed herein include a therapeutically-effective amount of a FLAP inhibitor formulated for dermal administration
摘要翻译： 本文描述的是用于治疗皮肤病，病症或病症的局部制剂。 本文公开的局部制剂包括治疗有效量的配制用于皮肤给药的FLAP抑制剂
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公开(公告)号：US5182367A
公开(公告)日：1993-01-26
申请号：US618449
申请日：1990-11-30
申请人： John W. Gillard , Jacques-Yves Gauthier , Jillian F. Evans , Rejean Fortin , Yvan Guinon , Richard A. F. Dixon , Douglas K. Miller
发明人： John W. Gillard , Jacques-Yves Gauthier , Jillian F. Evans , Rejean Fortin , Yvan Guinon , Richard A. F. Dixon , Douglas K. Miller
IPC分类号： C07K14/47
CPC分类号： C07K14/4705
摘要： An 18kD protein (FLAP) has been isolated from rat and human cells which is necessary for production of leukotrienes from arachidonic acid in mammalian cells containing 5-lipoxygenase. The gene (cDNA) encoding for FLAP has also been produced.
摘要翻译： 从含有5-脂肪氧合酶的哺乳动物细胞中的花生四烯酸生产白细胞三烯所需的大鼠和人细胞已经分离出18kD蛋白（FLAP）。 编码FLAP的基因（cDNA）也已经生产。
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