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1.发明申请N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 有权PROSTAGLANDIN D2受体的N，N-取代的氨基二苯乙烯拮抗剂公开(公告)号：US20120058123A1
公开(公告)日：2012-03-08
申请号：US13272180
申请日：2011-10-12
申请人： John Howard HUTCHINSON , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
发明人： John Howard HUTCHINSON , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
IPC分类号： A61K31/195 , A61K31/4164 , A61K31/4418 , A61K31/505 , A61K39/395 , A61K31/7028 , A61P11/00 , A61P11/08 , A61P11/14 , A61P25/04 , A61K31/27 , A61K31/5375
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US08049015B2
公开(公告)日：2011-11-01
申请号：US12568571
申请日：2009-09-28
申请人： John Howard Hutchinson , Nicholas Simon Stock , Jeffrey Roger Roppe , Jill Melissa Scott , Brian Andrew Stearns , Yen Pham Truong , Deborah Volkots , Timothy Parr
发明人： John Howard Hutchinson , Nicholas Simon Stock , Jeffrey Roger Roppe , Jill Melissa Scott , Brian Andrew Stearns , Yen Pham Truong , Deborah Volkots , Timothy Parr
IPC分类号： C07D213/00 , C07D211/72 , C07D211/78 , A61K31/44
CPC分类号： C07D213/55 , C07D213/56 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/89 , C07D401/10 , C07D401/12
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US20110082181A1
公开(公告)日：2011-04-07
申请号：US12896080
申请日：2010-10-01
申请人： Thomas Jon SEIDERS , Lucy Zhao , Jeannie M. Arruda , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Nicholas Simon Stock , Deborah Volkots
发明人： Thomas Jon SEIDERS , Lucy Zhao , Jeannie M. Arruda , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Nicholas Simon Stock , Deborah Volkots
IPC分类号： A61K31/42 , C07D261/14 , C07D261/08 , A61P35/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P1/16 , A61P27/02 , A61P29/00
CPC分类号： C07D261/08 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/519 , C07D261/14 , C07D261/18 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D495/04
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号：US20100280049A1
公开(公告)日：2010-11-04
申请号：US12741808
申请日：2008-10-31
IPC分类号： A61K31/4965 , C07D471/10 , C07D487/04 , A61K31/438 , A61K31/519 , C07D471/04 , A61P11/06 , A61P11/02 , A61P11/08 , A61P37/08 , A61P19/02 , A61P17/06 , A61P17/00 , A61P11/00 , A61P1/00 , A61P35/00 , A61P9/10 , A61P7/00 , A61P25/00
CPC分类号： C07D471/10 , C07D209/54
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds that antagonize the PGD2 activated chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2). Also described herein are methods of using such CRTH2 antagonists, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2 mediated conditions or diseases.
摘要翻译： 本文描述了含有拮抗在TH2细胞（CRTH2）上表达的PGD2激活的化学引诱物受体同源分子的化合物的化合物和药物组合物。 本文还描述了使用这种CRTH2拮抗剂单独和与其它化合物组合用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US20120289522A1
公开(公告)日：2012-11-15
申请号：US13498491
申请日：2010-10-01
申请人： Thomas J. Seiders , Lucy Zhao , Jeannie Arruda , Bowei Wang , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Ryan Clark , Heather Renee Coate , Nicholas Simon Stock , Deborah Volkots
发明人： Thomas J. Seiders , Lucy Zhao , Jeannie Arruda , Bowei Wang , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Ryan Clark , Heather Renee Coate , Nicholas Simon Stock , Deborah Volkots
IPC分类号： A61K31/42 , C07D261/08 , C07D413/12 , A61K31/4439 , C07D417/12 , A61P17/00 , C07D495/04 , A61K31/519 , A61P11/00 , A61P13/12 , A61P1/16 , C07D261/14 , A61K31/428
CPC分类号： C07D261/08 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/519 , C07D261/14 , C07D261/18 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D495/04
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
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公开(公告)号：US08168678B2
公开(公告)日：2012-05-01
申请号：US12362439
申请日：2009-01-29
IPC分类号： A01N37/12
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
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7.发明申请CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 失效循环二醛化合物作为PROSTAGLANDIN D2受体的拮抗剂公开(公告)号：US20110098302A1
公开(公告)日：2011-04-28
申请号：US12867476
申请日：2009-02-12
申请人： John Howard Hutchinson , Thomas Jon Seiders , Brian Andrew Stearns , Bowei Wang , Yen Pham Truong , Jeannie M. Arruda
发明人： John Howard Hutchinson , Thomas Jon Seiders , Brian Andrew Stearns , Bowei Wang , Yen Pham Truong , Jeannie M. Arruda
IPC分类号： A61K31/5377 , C07D233/02 , A61K31/4166 , C07D207/46 , A61K31/40 , C07D263/58 , A61K31/423 , C07D413/10 , C07D417/10 , A61K31/427 , A61K31/4439 , A61P11/06 , A61P37/08 , A61P11/00 , A61P19/02 , A61P35/00 , A61P17/06 , A61P1/00 , A61P17/02
CPC分类号： C07D233/32 , C07D207/38 , C07D263/22 , C07D263/52 , C07D413/12 , C07D417/12
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述的PGD 2受体的拮抗剂的药物组合物和药物，以及将PGD2受体单独和与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2的方法 介导的病症或疾病。
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8.发明授权N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors 有权前列腺素D2受体的N，N-二取代的氨基烷基联苯拮抗剂公开(公告)号：US08338484B2
公开(公告)日：2012-12-25
申请号：US13297160
申请日：2011-11-15
IPC分类号： A01N37/12
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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9.发明申请N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 有权PROSTAGLANDIN D2受体的N，N-取代的氨基二苯乙烯拮抗剂公开(公告)号：US20120059055A1
公开(公告)日：2012-03-08
申请号：US13297160
申请日：2011-11-15
申请人： John Howard HUTCHINSON , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang
发明人： John Howard HUTCHINSON , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang
IPC分类号： A61K31/27 , C07C233/51 , C07C311/13 , C07C317/50 , C07C275/24 , C07C271/34 , C07C235/34 , C07C233/63 , A61K31/195 , A61P11/00 , A61P37/08 , A61P29/00 , A61P11/06 , A61P11/02 , C07C271/22
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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![CYCLOALKANE[B]AZAINDOLE ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS](/abs-image/US/2011/12/08/US20110301168A1/abs.jpg.150x150.jpg)
10.发明申请公开(公告)号：US20110301168A1
公开(公告)日：2011-12-08
申请号：US13127219
申请日：2009-11-05
IPC分类号： A61K31/4985 , C07D487/04 , A61K31/437 , A61K31/519 , A61P29/00 , A61P37/08 , A61P11/06 , A61P11/00 , A61P9/12 , A61P19/02 , A61P17/06 , A61P9/10 , A61P9/00 , A61P35/00 , A61P43/00 , A61P1/00 , A61P11/02 , A61P11/12 , A61P11/14 , A61P11/08 , A61P7/10 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4427
摘要： Described herein are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是PGD 2受体的拮抗剂。 还描述了包括本文所述化合物的药物组合物和药物，以及使用PGD2受体单独和与其它化合物组合的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症的方法 或疾病。
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