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31.发明授权3,4,5-Trichloro-N,N-di(loweralkyl)-2-(mercapto) benzenesulfonamides 失效3,4,5-三氯-N，N-二（低级烷基）-2-（巯基）苯磺酰胺
公开(公告)号：US4041073A
公开(公告)日：1977-08-09
申请号：US730034
申请日：1976-10-06
IPC分类号： C07C143/78
摘要： Compounds are prepared corresponding to the formula ##STR1## WHEREIN R represents hydrogen or methylenethiocyanate (--CH.sub.2 SCN) and each of R.sup.1 and R.sup.2 represents loweralkyl of 1 to 4 carbon atoms. Those compounds wherein R is methylenethiocyanate have been found to be active antimicrobial agents and those wherein R is hydrogen are useful as intermediates therefor.
摘要翻译： 化合物是根据式（Ⅰ）表示的化合物，其中R表示氢或亚甲基硫氰酸酯（-CH 2 SCN），R 1和R 2各自表示1至4个碳原子的低级烷基。 已经发现其中R是亚甲硫氰酸酯的那些化合物是活性抗微生物剂，其中R是氢的那些化合物可用作其中间体。
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公开(公告)号：US4014875A
公开(公告)日：1977-03-29
申请号：US567455
申请日：1975-04-11
IPC分类号： C07D265/30 , C07D295/26
CPC分类号： C07D295/26 , C07D265/30
摘要： This invention concerns dibromo- and tribromomethanesulfonamides of the formula ##STR1## wherein ##STR2## is a heterocyclic ring which may contain oxygen as another hetero atom and may be substituted with 1 to 2 lower alkyl groups, and x is 2 or 3. The compounds have antimicrobial activity.
摘要翻译： 本发明涉及式“IMAGE”的二溴和三溴甲磺酰胺，其中
是可以含有氧作为另一个杂原子并且可以被1至2个低级烷基取代的杂环，并且x是2或3。化合物 具有抗菌活性。 -
33.发明授权
公开(公告)号：US3987095A
公开(公告)日：1976-10-19
申请号：US465035
申请日：1974-04-29
IPC分类号： C07D295/26 , C07C143/75 , A61K31/18 , C07C143/79
CPC分类号： C07D295/26
摘要： The compounds of the formula ##SPC1##In which R independently is hydrogen, lower alkyl, lower alkoxy, halo or trifluoromethyl; x is 1 to 2; n is 1 to 3, and R.sub.1 and R.sub.2 independently are hydrogen, lower alkyl or phenyl and together with the nitrogen atom form a heterocycle which may contain an oxygen atom as a hetero atom. The compounds are prepared by reacting the corresponding N-substituted-1-(arylthio)methanesulfonamide with small, incremental amounts up to substantially equimolar of 30% hydrogen peroxide in glacial acetic acid at 65.degree.-70.degree. C., to obtain the sulfinyl compound, or substantially two equimolar proportions of 30% hydrogen peroxide in glacial acetic acid at reflux temperature to obtain the sulfonyl compound, and recovering the corresponding sulfinyl or sulfonyl product.
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公开(公告)号：US06362373B1
公开(公告)日：2002-03-26
申请号：US09661421
申请日：2000-09-13
IPC分类号： C07C20922
CPC分类号： C07D295/096 , C07B2200/07 , C07C213/04 , C07C215/44 , C07C2601/14 , C07C2603/74 , C07D209/44 , C07D211/14 , C07D211/62 , C07D217/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/205
摘要： The disclosed invention comprises a compound having the formula: in which R1 and R2 independently represent a hydrogen or an alkyl group of 4 carbon atoms or greater. Further disclosed is a process for the preparation of the disclosed chiral amino alcohols from a starting amine compound and a limonene oxide.
摘要翻译： 所公开的发明包括具有下式的化合物：其中R 1和R 2独立地表示氢或4个或更多个碳原子的烷基。 进一步公开的是从起始胺化合物和柠檬烯氧化物制备公开的手性氨基醇的方法。
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公开(公告)号：US5641404A
公开(公告)日：1997-06-24
申请号：US596338
申请日：1996-02-20
CPC分类号： B01D15/3833 , B01D15/203 , C07B57/00
摘要： A process for separating enantiomeric mixtures by liquid chromatography using a stationary phase that includes cellulose or amylose derivative and a mobile phase that includes methanol and pentane, the concentration of methanol in the mobile phase being greater than one tenth percent by volume and less than the saturation concentration of methanol in the mobile phase, the concentration of pentane being at least that necessary to resolve the enantiomeric mixture into its enantiomers with a resolution at least one and one half times greater than the pentane of the mobile phase is replaced with hexane.
摘要翻译： PCT No.PCT / US94 / 09687 371日期1996年2月20日 102（e）日期1996年2月20日PCT 1994年8月25日PCT公布。 第WO95 / 05879号公报 日期1995年3月2日使用包含纤维素或直链淀粉衍生物的固定相和包含甲醇和戊烷的流动相通过液相色谱分离对映异构体混合物的方法，流动相中甲醇的浓度大于体积百分之十 并且小于流动相中甲醇的饱和浓度，所替代的戊烷浓度至少为将对映异构体混合物分解成其对映异构体所必需的浓度至少比流动相的戊烷高1.5倍。 用己烷。
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公开(公告)号：US5466798A
公开(公告)日：1995-11-14
申请号：US138612
申请日：1993-10-15
IPC分类号： C07C213/00 , C07C215/08 , C07D295/084 , C07D295/088 , C07D295/096 , C07D223/02 , C07D207/00 , C07F5/02
CPC分类号： C07D295/096 , C07C213/00 , C07C215/08 , C07D295/084 , C07D295/088 , C07D295/092
摘要： The present invention relates to novel, powerful reducing agents, lithium aminoborohydrides which are prepared by addition of BH.sub.3 .cndot.THF to the corresponding dialkylamine at 25.degree. C. to give the intermediate amineborane complex. Subsequent deprotonation by strong base, e.g. n-BuLi, yields the aminoborohydride quantitatively. Lithium aminoborohydrides are powerful reducing agents, comparable in strength to lithium aluminum hydride. The activity is determined by the dialkylamine. Lithium pyrrolidinoborohydride has unique activity and selectivity in its reducing properties. Esters, lactones and anhydrides are reduced cleanly at 25.degree. C. to give the corresponding alcohols, while carboxylic acids are not reduced. Test reductions show that lithium pyrrolidinoborohydride is also capable of reducing a wide range of functional groups including amides, epoxides, oximes, nitriles and halides.
摘要翻译： 本发明涉及通过在25℃下向相应的二烷基胺中加入BH3.THF而制得的新的强大的还原剂氨基硼酸锂，得到中间体胺硼烷络合物。 随后通过强碱去质子化，例如 n-BuLi，定量产生氨基硼氢化钠。 氨基硼氢化锂是强大的还原剂，其强度与氢化铝锂相当。 活性由二烷基胺决定。 吡咯烷基硼氢化锂在还原性能方面具有独特的活性和选择性。 酯，内酯和酸酐在25℃下干净地还原，得到相应的醇，而羧酸不被还原。 测试减少表明，吡咯烷基硼氢化锂还能够减少宽范围的官能团，包括酰胺，环氧化物，肟，腈和卤化物。
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公开(公告)号：US4309554A
公开(公告)日：1982-01-05
申请号：US144485
申请日：1980-04-28
IPC分类号： C07D333/34
CPC分类号： C07D333/34
摘要： 3-(2-Thiophenesulfonyl)-2-halopropanenitriles of the formula ##STR1## wherein R is H, C.sub.1-4 alkyl, Br or Cl and X is Br or Cl. The compounds have antimicrobial utility.
摘要翻译： 其中R是H，C 1-4烷基，Br或Cl和X是Br或Cl的式（I）的3-（2-噻吩磺酰基）-2-卤代丙腈。 这些化合物具有抗菌效用。
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38.发明授权4-(2,2-Dichloro-1,1-difluoroethoxybenzene) sulfonyl chloride and its preparation 失效4-（2,2-二氯-1,1-二氟乙氧基苯）磺酰氯及其制备方法
公开(公告)号：US4111988A
公开(公告)日：1978-09-05
申请号：US758283
申请日：1977-01-10
IPC分类号： C07C41/06 , C07C43/225 , C07C309/87 , C07C143/70
CPC分类号： C07C41/06 , C07C309/87
摘要： The compound of this invention is prepared by reacting phenol as such or as its alkali metal phenate with dichlorodifluoroethylene to form 2,2-dichloro-1,1-difluoroethoxybenzene and reacting the latter with chlorosulfonic acid and recovering the reaction product. The compound of this invention, when reacted with acrylonitrile gives the antimicrobial compound, 2-chloro-3-(4-(2,2-dichloro-1,1-difluoroethoxy)phenyl)sulfonyl)propanenitrile.
摘要翻译： 本发明的化合物通过使苯酚本身或其碱金属酚盐与二氯二氟乙烯反应形成2,2-二氯-1,1-二氟乙氧基苯并使其与氯磺酸反应并回收反应产物来制备。 本发明化合物当与丙烯腈反应时，得到抗微生物化合物2-氯-3-（4-（2,2-二氯-1,1-二氟乙氧基）苯基）磺酰基）丙腈。
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公开(公告)号：US4094880A
公开(公告)日：1978-06-13
申请号：US726346
申请日：1976-09-24
IPC分类号： C07D285/08 , C07D285/12 , C07D285/125
CPC分类号： C07D285/08 , C07D285/125
摘要： Novel compounds, i.e. 3,5-bis(chloromethylthio)-4-cyanoisothiazole; 2,5-bis(chloromethylthio)-1,3,4-thiadiazole; and 3,5-bis(chloromethylthio)-1,2,4-thiadiazole are prepared by reacting an alkali metal aryl mercaptide with bromochloromethane in the presence of a quaternary ammonium salt. These novel compounds have microbiological activity and are also useful as intermediates in the preparation of the corresponding thiocyanomethylthio compounds which have antimicrobial activity.
摘要翻译： 新型化合物，即3,5-双（氯甲硫基）-4-氰基异噻唑; 2,5-双（氯甲硫基）-1,3,4-噻二唑; 和3,5-双（氯甲硫基）-1,2,4-噻二唑通过碱金属芳基硫醇与溴氯甲烷在季铵盐的存在下反应来制备。 这些新化合物具有微生物活性，并且也可用作制备具有抗微生物活性的相应硫氰基甲硫基化合物的中间体。
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公开(公告)号：US4061639A
公开(公告)日：1977-12-06
申请号：US716747
申请日：1976-08-23
IPC分类号： C07D215/36 , A61K31/47
CPC分类号： C07D215/36
摘要： Quinolinesulfonyl hydrazine and quinolinesulfonyl bromide compounds of the formula ##STR1## wherein R is either a bromine radical or a hydrazine radical. The quinolinesulfonyl hydrazine compounds are useful as intermediates for making quinolinesulfonyl bromide compounds, the latter being useful as antimicrobials.
摘要翻译： 喹啉磺酰肼和喹啉磺酰溴化合物，其结构式为：其中R为溴基或肼基。 喹啉磺酰肼化合物可用作制备喹啉磺酰溴化合物的中间体，后者可用作抗微生物剂。
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