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公开(公告)号:US08324203B2
公开(公告)日:2012-12-04
申请号:US12691684
申请日:2010-01-21
申请人: Robin D. Clark , Nicholas C. Ray , Paul Blaney , Christopher Hurley , Hazel Hunt , David Clark , Karen Williams
发明人: Robin D. Clark , Nicholas C. Ray , Paul Blaney , Christopher Hurley , Hazel Hunt , David Clark , Karen Williams
IPC分类号: A61K31/538 , A61K31/47 , A61K31/5377 , A61K31/506 , A61K31/497
CPC分类号: C07D217/04 , C07D217/02 , C07D217/06 , C07D217/08 , C07D401/10 , C07D401/12 , C07D405/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/10 , C07D513/04 , C07D513/06
摘要: The present invention provides a novel class of azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
摘要翻译: 本发明提供了一类新颖的氮杂环丁烷化合物和使用该化合物作为糖皮质激素受体调节剂的方法。
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公开(公告)号:US20120225856A1
公开(公告)日:2012-09-06
申请号:US13476776
申请日:2012-05-21
IPC分类号: A61K31/437 , A61K31/5377 , A61K31/496 , A61K31/538
CPC分类号: C07D471/04
摘要: The present invention provides a novel class of fused ring azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
摘要翻译: 本发明提供了一类新颖的稠环氮杂环丁烷化合物和使用该化合物作为糖皮质激素受体调节剂的方法。
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公开(公告)号:US08258152B2
公开(公告)日:2012-09-04
申请号:US12664303
申请日:2008-06-11
申请人: Hazel Joan Dyke , Stephen Price , Karen Williams
发明人: Hazel Joan Dyke , Stephen Price , Karen Williams
IPC分类号: A01N43/42 , A61K31/44 , C07D413/00
CPC分类号: C07D471/04
摘要: The invention relates to N-substituted azaindolyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to N-substituted azaindolyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译: 本发明涉及具有抗癌和/或抗炎活性的更优选的具有抗癌和/或抗炎活性的式I的N-取代的氮杂吲哚基化合物,更具体地涉及抑制MEK激酶活性的N-取代的阿魏酰基化合物。 本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。 本发明还涉及将化合物用于体外,原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。
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公开(公告)号:US20110240914A1
公开(公告)日:2011-10-06
申请号:US13079804
申请日:2011-04-04
CPC分类号: C08G65/2624 , B01D19/04 , B01D19/0413 , C08L71/02
摘要: Disclosed is a method for inhibiting the formation of foam in aqueous systems by adding foam control composition including a polyoxethylene and/or a polyoxypropylene nonionic fatty acid derivative and a quaternary ammonium surfactant.
摘要翻译: 公开了通过添加包含聚氧乙烯和/或聚氧丙烯非离子脂肪酸衍生物和季铵表面活性剂的泡沫控制组合物来抑制水性体系中泡沫形成的方法。
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公开(公告)号:US07893085B2
公开(公告)日:2011-02-22
申请号:US11894345
申请日:2007-08-20
申请人: Pascal Pierre Savy , Stephen Price , Hazel Joan Dyke , John Gary Montana , Karen Williams , Mark S. Stanley , Liang Bao
发明人: Pascal Pierre Savy , Stephen Price , Hazel Joan Dyke , John Gary Montana , Karen Williams , Mark S. Stanley , Liang Bao
IPC分类号: C07D221/00 , A61K31/4365 , A61P35/00 , A61P29/00 , C07D241/00 , C07D487/04 , A61K31/519 , A61K31/5025
CPC分类号: C07D495/04
摘要: The invention relates to azabenzothiophenyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzothiophenyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译: 本发明涉及具有抗癌和/或抗炎活性的式I的氮杂苯并噻吩基化合物,更具体地涉及抑制MEK激酶活性的氮杂苯并噻吩基化合物。 本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。 本发明还涉及将化合物用于体外,原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。
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公开(公告)号:US20090275600A1
公开(公告)日:2009-11-05
申请号:US12499753
申请日:2009-07-08
申请人: Robin D. Clark , Nicolas C. Ray , Karen Williams , Peter H. Cracket , Gwen Hickin , David A. Clark
发明人: Robin D. Clark , Nicolas C. Ray , Karen Williams , Peter H. Cracket , Gwen Hickin , David A. Clark
IPC分类号: A61K31/506 , A61P25/18
CPC分类号: C07D239/545 , A61K31/506 , A61K31/513 , A61K31/551 , C07D401/04 , C07D403/04
摘要: The present invention provides a novel class of modified pyrimidine compounds and compositions and methods of using the compounds as glucocorticoid receptor modulators.
摘要翻译: 本发明提供了一类新颖的改良嘧啶化合物及其组合物和使用该化合物作为糖皮质激素受体调节剂的方法。
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公开(公告)号:US20070023064A1
公开(公告)日:2007-02-01
申请号:US11194781
申请日:2005-08-01
申请人: Nicole Gilbert , Karen Williams
发明人: Nicole Gilbert , Karen Williams
摘要: An apparatus suitable for ultrasonically cleaning objects is disclosed. The apparatus includes a housing and a cleaning chamber within the housing. The apparatus also includes drainer that can be moved between a cleaning position in a lower region of the apparatus and a draining position in an upper region of the apparatus. The drainer is configured to engage at least a portion of the upper region of the housing to thereby position the drainer in the draining position. The apparatus also includes a transducer for transmitting ultrasonic energy into the cleaning chamber.
摘要翻译: 公开了一种适用于超声波清洗物体的设备。 该装置包括在壳体内的壳体和清洁室。 该装置还包括可以在设备的下部区域中的清洁位置与设备的上部区域中的排水位置之间移动的排水器。 排水器构造成与壳体的上部区域的至少一部分接合,从而将排水器定位在排水位置。 该装置还包括用于将超声波能量传送到清洁室中的换能器。
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公开(公告)号:US20060268130A1
公开(公告)日:2006-11-30
申请号:US11139456
申请日:2005-05-26
IPC分类号: H04N5/262
CPC分类号: H04N5/2624 , H04N5/23238 , H04N5/23293
摘要: A method and apparatus are disclosed for accomplishing in-camera stitching of a high-resolution panoramic photograph from a set of component photographs while providing a satisfactory user experience. A low-resolution panorama is stitched, and a user of the camera performs a review of the low-resolution panorama using a display comprised in the camera. During the review, a high-resolution panoramic photograph is stitched by the camera in a background process.
摘要翻译: 公开了一种方法和装置,用于在提供令人满意的用户体验的同时从一组组件照片中完成高分辨率全景照片的相机内拼接。 低分辨率全景图被缝合,并且相机的用户使用相机中包含的显示器来执行对低分辨率全景图的检查。 在审查期间,高分辨率全景照片由相机在后台处理中缝合。
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