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公开(公告)号：US20080124344A1
公开(公告)日：2008-05-29
申请号：US11814549
申请日：2006-07-18
申请人： Katherin E. Combs , Ling Ling Culbertson , Juan Delmas-Mata , Frederic de Sauvage , Liangfen Fan , Gretchen Frantz , Leslie Jane Green , Erin Marie Massey , Dina Rebecca McLain , Charles Montgomery , Bobby Joe Payne , Franklin Peale , Heidi Phillips , Michelle Rohrer , Tracy E.W. Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Ching-Yun Wang , Wen Xiong , Peter Vogel
发明人： Katherin E. Combs , Ling Ling Culbertson , Juan Delmas-Mata , Frederic de Sauvage , Liangfen Fan , Gretchen Frantz , Leslie Jane Green , Erin Marie Massey , Dina Rebecca McLain , Charles Montgomery , Bobby Joe Payne , Franklin Peale , Heidi Phillips , Michelle Rohrer , Tracy E.W. Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Ching-Yun Wang , Wen Xiong , Peter Vogel
IPC分类号： A61K39/395 , A01K67/00 , A61P43/00
CPC分类号： C12N15/8509 , A01K2217/075 , A01K2267/0306 , A01K2267/0362 , A01K2267/0375
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO226，PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断 ，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
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公开(公告)号：US07390882B2
公开(公告)日：2008-06-24
申请号：US11248718
申请日：2005-10-11
申请人： Belinda Cairns , Gretchen Frantz , Hartmut Koeppen , Paul Polakis , Thomas D. Wu , Zemin Zhang
发明人： Belinda Cairns , Gretchen Frantz , Hartmut Koeppen , Paul Polakis , Thomas D. Wu , Zemin Zhang
IPC分类号： C07K1/00
CPC分类号： C07K16/18 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/30 , C07K16/3023 , C07K16/40 , C07K2317/73 , G01N33/57407
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US08084200B2
公开(公告)日：2011-12-27
申请号：US12402434
申请日：2009-03-11
申请人： Avi J. Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin L. Gurney , Paul Polakis , Andrew Polson , William I. Wood , Thomas D. Wu , Zemin Zhang
发明人： Avi J. Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin L. Gurney , Paul Polakis , Andrew Polson , William I. Wood , Thomas D. Wu , Zemin Zhang
IPC分类号： C12Q1/68
CPC分类号： C07K16/30 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20050123925A1
公开(公告)日：2005-06-09
申请号：US10712892
申请日：2003-11-12
申请人： Avi Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin Gurney , Paul Polakis , Andrew Polson , William Wood , Thomas Wu , Zemin Zhang
发明人： Avi Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin Gurney , Paul Polakis , Andrew Polson , William Wood , Thomas Wu , Zemin Zhang
IPC分类号： A61K20060101 , A61K38/16 , A61K39/395 , C07K16/18 , C07K16/30 , C12N15/13 , C12P21/02 , C12Q1/68 , G01N33/574
CPC分类号： C07K16/30 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20090186363A1
公开(公告)日：2009-07-23
申请号：US12402434
申请日：2009-03-11
申请人： Avi J. Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin L. Gurney , Paul Polakis , Andrew Polson , William I. Wood , Thomas D. Wu , Zemin Zhang
发明人： Avi J. Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin L. Gurney , Paul Polakis , Andrew Polson , William I. Wood , Thomas D. Wu , Zemin Zhang
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C07K16/30 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20070054361A1
公开(公告)日：2007-03-08
申请号：US11486298
申请日：2006-07-13
申请人： Avi Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin Gurney , Paul Polakis , Andrew Polson , William Wood , Thomas Wu , Zemin Zhang
发明人： Avi Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin Gurney , Paul Polakis , Andrew Polson , William Wood , Thomas Wu , Zemin Zhang
CPC分类号： C07K16/30 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US07547768B2
公开(公告)日：2009-06-16
申请号：US11943454
申请日：2007-11-20
申请人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
发明人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
IPC分类号： C07K16/00 , C12P21/08 , C12P21/04 , A61K39/395 , C07H21/04
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及可用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US20080124739A1
公开(公告)日：2008-05-29
申请号：US11943454
申请日：2007-11-20
申请人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
发明人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20070048825A1
公开(公告)日：2007-03-01
申请号：US11538517
申请日：2006-10-04
申请人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan Spencer , Thomas Wu , Zemin Zhang
发明人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan Spencer , Thomas Wu , Zemin Zhang
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20110274690A1
公开(公告)日：2011-11-10
申请号：US12422424
申请日：2009-04-13
申请人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
发明人： Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
IPC分类号： A61K39/395 , A61P35/00 , C12N5/09 , G01N33/566 , C07K16/18
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。
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